|
Hyperglycemia
|
0.300 |
Biomarker
|
disease |
BEFREE |
Methylation of Specific CpG Sites in <i>IL-1β and IL1R1</i> Genes is Affected by Hyperglycaemia in Type 2 Diabetic Patients.
|
31476928 |
2020 |
|
Hyperglycemia
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Importantly, it was found that GF promoted the expression of TNF-α and IL-1β in the hippocampus of the GF rats while continuous hyperglycemia in CHG rats had little effect on that.
|
31713299 |
2019 |
|
Hyperglycemia
|
0.300 |
Biomarker
|
disease |
BEFREE |
IL-1β but not hyperglycemia increases the shedding of syndecan-4 from GEnC in an MMP9-dependent manner.
|
30703289 |
2019 |
|
Hyperglycemia
|
0.300 |
Biomarker
|
disease |
BEFREE |
In primary cultured human brain microvascular endothelial cells (HBMEC), hyperglycemia (25 mM glucose) plus interleukin 1 beta (20 ng/ml) (HG-IL1β) served as T2DM insult in vitro.
|
31101061 |
2019 |
|
Hyperglycemia
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Our results showed that hyperglycemia greatly increased inflammation in diabetic rats or HRECs exposed to high glucose, increasing the levels of caspase-1, interleukin-1β (IL-1β) and IL-18.
|
30657854 |
2019 |
|
Hyperglycemia
|
0.300 |
Biomarker
|
disease |
BEFREE |
Instead, salivary gland dysfunction was associated with hyperglycemia and elevation of serum IL1β, IL16, and CXCL13.
|
31784615 |
2019 |
|
Hyperglycemia
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
When STZ was injected to induce diabetes in mice, neither hyperglycemia nor hypoinsulinemia was developed in agomelatine pretreated mice and 6 weeks after development of diabetes, agomelatine treatment significantly decreased levels of IL-1β mRNA in raphe nucleus and nucleus accumbens.
|
30216538 |
2019 |
|
Hyperglycemia
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
<i>In vitro</i> experiments in rat macrophages showed that hyperglycemia treatment suppresses Nrf2 activation, resulting in oxidative stress with decreased expression of antioxidant genes, including NAD(P)H:quinone oxidoreductase 1 and heme oxygenase 1, together with increased secretion of proinflammatory cytokines, including interleukin 1β (IL1β), IL6, and monocyte chemoattractant protein-1.
|
31616304 |
2019 |
|
Hyperglycemia
|
0.300 |
Biomarker
|
disease |
BEFREE |
Our findings reveal a novel mechanism of acute hyperglycemia postburn in which impaired insulin secretory capacity mediated by IL-1β leads to acute hyperglycemia.
|
30419339 |
2019 |
|
Hyperglycemia
|
0.300 |
Biomarker
|
disease |
BEFREE |
Downregulation of IL1R1 in individuals with mild hyperglycemia may indicate an attempt to reduce the pro-inflammatory effects of IL-1β via auto-stimulation.
|
29851525 |
2018 |
|
Hyperglycemia
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In addition, the results revealed that the expression of CCL5, IL-1β and TNF-α was increased in the high-glucose group, and that the NO produced by HUVECs decreased due to hyperglycemia; however, co-culture with OMT or A2B siRNA abolished these effects.
|
29402837 |
2018 |
|
Hyperglycemia
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The untreated diabetic group showed hyperglycemia and increased diuresis, creatinine clearance, proteinuria, glycosuria and urinary excretion of <i>N</i>-acetyl-β-d-glucosaminidase (NAG), as well as increased oxidative stress and the expression of interleukin 1β (IL-1β), IL-6, nuclear factor kappa beta (NFκβ) and transforming growth factor-β1 (TGF-β1) in plasma and kidney.
|
30314265 |
2018 |
|
Hyperglycemia
|
0.300 |
Biomarker
|
disease |
BEFREE |
This study was based on the hypothesis that IL-1β and its central regulator, the inflammasome, may play a role in the inflammatory condition exhibited by placental tissues from mothers with different gestational hyperglycemia levels.
|
30114628 |
2018 |
|
Hyperglycemia
|
0.300 |
Biomarker
|
disease |
BEFREE |
Hyperglycemia induces a placental trophoblast inflammatory (IL-1β, IL-6, IL-8), antiangiogenic (sFlt-1, sEndoglin), and anti-migratory profile.
|
30175447 |
2018 |
|
Hyperglycemia
|
0.300 |
Biomarker
|
disease |
BEFREE |
These findings together show that SMR acts as a protector against HG-related stresses not only by lowering hyperglycemia but also suppressing HG- and inflammasome-mediated IL-1β expressions to improve insulin resistance.
|
29753610 |
2018 |
|
Hyperglycemia
|
0.300 |
Biomarker
|
disease |
BEFREE |
The hyperglycemia can directly promote an inflammatory state where the increase C-reactive (CRP) and cytokines, such as interleukins (IL-1 and IL-6), which contribute to the development of cardiovascular diseases.
|
28939513 |
2018 |
|
Hyperglycemia
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Paeoniflorin suppressed STZ-induced IBA-1 and IL-1β expression and decreased STZ-induced high blood glucose level.
|
28639050 |
2017 |
|
Hyperglycemia
|
0.300 |
Biomarker
|
disease |
BEFREE |
We conclude that an interdependent oxidative stress response to hyperglycemia perturbs neutrophil cytoskeletal stability leading to MP production and IL-1β synthesis.
|
28972154 |
2017 |
|
Hyperglycemia
|
0.300 |
Biomarker
|
disease |
BEFREE |
In this study, we examined the underlying mechanisms of secreting IL-1β during hyperglycemia, with a focus on the alteration of Ca<sup>2+</sup> homeostasis and lysosomal exocytosis.
|
28970837 |
2017 |
|
Hyperglycemia
|
0.300 |
Biomarker
|
disease |
BEFREE |
Furthermore, CORM-3-treated mice showed substantial reduction in IL-1β production by hyperglycemia in a mouse model of streptozotocin (STZ)-induced diabetes.
|
28942141 |
2017 |
|
Hyperglycemia
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Acute hyperglycemia was shown to promote gene expression of proinflammatory cytokines (il1β, il6, il8, and tnfα) in the brain and chronic hyperglycemia to impair expression of genes involved in the establishment of the blood-brain barrier (claudin 5a, zona occludens 1a and b).
|
27339277 |
2017 |
|
Hyperglycemia
|
0.300 |
Biomarker
|
disease |
BEFREE |
IL-1β is produced mainly by monocytes (MO), and hyperglycaemia may be able to modulate, in the cytoplasm of these cells, the assembly of a nucleotide-binding domain and leucine-rich repeat containing family pyrin (NLRP3)-inflammosome, a cytosolic multi-protein platform where the inactive pro-IL-1β is cleaved into active form, via caspase-1 activity.
|
26095630 |
2015 |
|
Hyperglycemia
|
0.300 |
Biomarker
|
disease |
BEFREE |
IL-1 signaling deficiency reduces diabetes incidence, islet IL-1β secretion, and hyperglycemia in animal models of diabetes.
|
23486342 |
2013 |
|
Hyperglycemia
|
0.300 |
Biomarker
|
disease |
BEFREE |
In this study, we set out to investigate whether hyperglycemia drives IL-1β production and caspase-1 activation in murine and human adipose tissue, thus inducing insulin resistance.
|
21270263 |
2011 |
|
Hyperglycemia
|
0.300 |
Biomarker
|
disease |
BEFREE |
To understand more about the molecular events that reduce insulin gene transcription, we examined the effects of hyperglycemia alone and together with the proinflammatory cytokine interleukin-1beta (IL-1beta) on signal transduction pathways that regulate insulin gene transcription.
|
20018749 |
2009 |