Inflammation
|
0.570 |
Biomarker
|
phenotype |
CTD_human |
Because of its high potency to induce inflammation, the activation and secretion of IL-1β is tightly regulated by large protein complexes, named inflammasomes.
|
28212736 |
2017 |
Inflammation
|
0.570 |
Therapeutic
|
phenotype |
RGD |
The results showed that intraplantar injection of carrageenan led to time-dependent development of peripheral inflammation, which resulted in a significant increase in the levels of tumor necrosis factor α (TNF-α) and interleukin 1 (IL-1) β, nitric oxide (NO) and prostaglandin E2 (PGE2) and also iNOS and COX-2 protein expression in inflamed paw.
|
26069367 |
2016 |
Inflammation
|
0.570 |
Therapeutic
|
phenotype |
RGD |
The galactose-binding lectin isolated from Bauhinia bauhinioides Mart seeds inhibits neutrophil rolling and adhesion via primary cytokines.
|
25706245 |
2015 |
Inflammation
|
0.570 |
Biomarker
|
phenotype |
CTD_human |
Mitochondrial dysfunction promotes and aggravates the inflammatory response in normal human synoviocytes.
|
24609059 |
2014 |
Inflammation
|
0.570 |
Biomarker
|
phenotype |
CTD_human |
In conclusion, the present study suggests that the neutralization of IL-1β attenuates silica-induced inflammation and fibrosis by inhibiting other inflammatory and fibrogenic mediators and modulating the Th1/Th2 balance.
|
23640035 |
2013 |
Inflammation
|
0.570 |
Biomarker
|
phenotype |
RGD |
Effect of endothelin receptor antagonist bosentan on chronic hypoxia-induced inflammation and chemoafferent neuron adaptation in rat carotid body.
|
22994521 |
2012 |
Inflammation
|
0.570 |
Biomarker
|
phenotype |
CTD_human |
Changes in expression of hepatic cytochrome P450 subfamily enzymes during development of adjuvant-induced arthritis in rats.
|
21467745 |
2011 |
Inflammation
|
0.570 |
Biomarker
|
phenotype |
CTD_human |
Gait and behavior in an IL1β-mediated model of rat knee arthritis and effects of an IL1 antagonist.
|
21437948 |
2011 |
Inflammation
|
0.570 |
Biomarker
|
phenotype |
CTD_human |
Primary rat mesangial cells (PRMCs) were treated with IL-1β to induce inflammation to resemble glomerulonephritis.
|
22001142 |
2011 |
Inflammation
|
0.570 |
Biomarker
|
phenotype |
LHGDN |
IL-32-dependent effects of IL-1beta on endothelial cell functions.
|
19228941 |
2009 |
Inflammation
|
0.570 |
Biomarker
|
phenotype |
RGD |
alpha-melanocyte-stimulating hormone gene transfer attenuates inflammation after bile duct ligation in the rat.
|
17676395 |
2008 |
Inflammation
|
0.570 |
Biomarker
|
phenotype |
LHGDN |
Interleukin-1 system in CNS stress: seizures, fever, and neurotrauma.
|
17656565 |
2007 |
Inflammation
|
0.570 |
Biomarker
|
phenotype |
LHGDN |
Our results indicate a primary role for IL-1beta and TNF-alpha in the triggering of preterm labor associated with inflammation or infection.
|
17132473 |
2006 |
Inflammation
|
0.570 |
Biomarker
|
phenotype |
CTD_human |
Genetic variation in selenoprotein S influences inflammatory response.
|
16227999 |
2005 |
Inflammation
|
0.570 |
Biomarker
|
phenotype |
LHGDN |
Regulation of MUC5AC mucin secretion and airway surface liquid metabolism by IL-1beta in human bronchial epithelia.
|
14527933 |
2004 |
Inflammation
|
0.570 |
Biomarker
|
phenotype |
RGD |
The aim of the present study was to test the hypothesis that IL-1beta mediates the functional consequences of inflammation during the course of delayed-type hypersensitivity response to bacillus Calmette-Guérin (BCG) in the hippocampus of Lewis rats.
|
15050649 |
2004 |
Inflammation
|
0.570 |
AlteredExpression
|
phenotype |
LHGDN |
Interleukin-17 increases the effects of IL-1 beta on muscle cells: arguments for the role of T cells in the pathogenesis of myositis.
|
12667656 |
2003 |
Inflammation
|
0.570 |
GeneticVariation
|
phenotype |
LHGDN |
In order to further define the clinical impact of genetic variation in this potent proinflammatory pathway we investigated the joint effects of two single nucleotide polymorphisms in the interleukin-1 beta gene [IL-1B(-511) and IL-1B(+3954)] and a variable number tandem repeat polymorphism in intron 2 of the interleukin 1 receptor antagonist gene (IL-1RN VNTR) on postintervention inflammation and occurrence of restenosis in 183 consecutive patients who underwent successful femoropopliteal PTA.
|
12958619 |
2003 |
Inflammation
|
0.570 |
Biomarker
|
phenotype |
LHGDN |
Secretion of interleukin-1beta by astrocytes mediates endothelin-1 and tumour necrosis factor-alpha effects on human brain microvascular endothelial cell permeability.
|
12807444 |
2003 |
Inflammation
|
0.570 |
Biomarker
|
phenotype |
CTD_human |
Pharmacological manipulation of the inflammatory cascade by the superoxide dismutase mimetic, M40403.
|
11181422 |
2001 |
Inflammation
|
0.570 |
Biomarker
|
phenotype |
CTD_human |
Interleukin-1 mediates a rapid inflammatory response after injection of adenoviral vectors into the brain.
|
9952427 |
1999 |