IL1B, interleukin 1 beta, 3553

N. diseases: 1801; N. variants: 22
Disease: Myasthenia Gravis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0026896
Disease: Myasthenia Gravis
Myasthenia Gravis 		0.050 AlteredExpression disease BEFREE In cultured MG PBMC, LPS challenge led to up-regulated P2X7R expression accompanied with increased production of IL-1β, IL-6, IL-17 and IL-21. 28458152 2017
CUI: C0026896
Disease: Myasthenia Gravis
Myasthenia Gravis 		0.050 GeneticVariation disease BEFREE Myasthenia gravis (MG) is an autoimmune disorder which has previously been shown to be associated with polymorphisms of several autoimmune predisposing genes, including IL-1, PTPN22, TNF-α and the MHC. 20942939 2010
CUI: C0026896
Disease: Myasthenia Gravis
Myasthenia Gravis 		0.050 Biomarker disease BEFREE IL-1 genes in myasthenia gravis: IL-1A -889 polymorphism associated with sex and age of disease onset. 11777547 2002
CUI: C0026896
Disease: Myasthenia Gravis
Myasthenia Gravis 		0.050 Biomarker disease BEFREE This lack of association between the IL-4 gene and disease contrasts to our previous results showing that MG is associated with higher secretor phenotypes of two prototype proinflammatory cytokine (TNF-alpha and IL-1) genes. 9916896 1998
CUI: C0026896
Disease: Myasthenia Gravis
Myasthenia Gravis 		0.050 Biomarker disease BEFREE We propose a possible pathogenetic role of IL-1beta and a possible intrinsic dyregulation of IL-1 in MG. 9521608 1998