|
Familial Mediterranean Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-1 blockers together with colchicine may be administered as first line therapy in familial Mediterranean fever with amyloidosis.
|
31383341 |
2019 |
|
Familial Mediterranean Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
This protein has been shown to act as a regulator of inflammation mediated by IL-1β, which plays a major role in the pathogenesis of FMF.
|
30686512 |
2019 |
|
Familial Mediterranean Fever
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Mechanistically, during FMF attack, neutrophils release chromatin structures called neutrophil extracellular traps (NETs), which are decorated with bioactive IL-1β.
|
31337526 |
2019 |
|
Familial Mediterranean Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-1 inhibitors have been shown to be effective in controlling attacks in crFMF patients.
|
30535829 |
2019 |
|
Familial Mediterranean Fever
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Medical records of FMF patients complicated with AA amyloidosis in our dedicated FMF center were retrospectively reviewed and those patients who ever treated with IL-1 inhibitors were enrolled into the study.
|
29578360 |
2019 |
|
Familial Mediterranean Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
As IL-1 inhibition is effective in FMF, AS cases carrying FMF-associated MEFV variants may benefit from such therapy.
|
30946743 |
2019 |
|
Familial Mediterranean Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we report our experience with the off-label use of anti-IL-1 agents in a large group of FMF patients.
|
28992387 |
2018 |
|
Familial Mediterranean Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
A favorable outcome could be obtained with the anti IL-1 in colchicine-resistant FMF patients.
|
28828621 |
2018 |
|
Familial Mediterranean Fever
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This study aims to investigate RAC1 expression and role in IL-1β and caspase-1 production and oxidative stress generation in FMF.
|
30698144 |
2018 |
|
Familial Mediterranean Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
Overall, this work identifies pyroptosis as a critical mechanism of IL-1β-dependent autoinflammation in FMF and highlights GSDMD inhibition as a potential antiinflammatory strategy in inflammasome-driven diseases.
|
29793924 |
2018 |
|
Familial Mediterranean Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-1β and IL-18 released by monocytes from healthy donors (HDs) and FMF patients were measured upon specific engagement of the Pyrin, NLRP3 and NLRC4 inflammasomes.
|
29040788 |
2018 |
|
Familial Mediterranean Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-1 is a cytokine that exerts a pivotal role in innate immunity and in the pathogenesis of some autoimmune diseases, such as rheumatoid arthritis, and in autoinflammatory disorders, as familial Mediterranean fever and cryopyrin-associated periodic syndromes.
|
29633070 |
2018 |
|
Familial Mediterranean Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interleukin (IL)-1α and IL-1β are proinflammatory cytokines that play a role in many diseases such as rheumatoid arthritis, juvenile rheumatoid arthritis, gout, and periodic inflammatory syndromes, including familial Mediterranean fever and Muckle-Wells syndrome.
|
29968152 |
2018 |
|
Familial Mediterranean Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
Areas covered: This review focuses on canakinumab, a fully human anti IL-1β antibody, treatment in FMF.
|
28362189 |
2017 |
|
Familial Mediterranean Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
Anti-IL-1 agents can control FMF attacks quite effectively and they have a promising role in the treatment of FMF.
|
27328763 |
2017 |
|
Familial Mediterranean Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
Colchicine is still the mainstay of FMF therapy, but IL-1 blockade is also effective if colchicine fails.
|
28497352 |
2017 |
|
Familial Mediterranean Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
To assess the efficacy and safety of the interleukin-1β (IL-1β) inhibitor canakinumab in all adolescent and adult patients with familial Mediterranean fever (FMF) identified from the Greek National Registry for off-label drug use between 2010 and 2015.
|
28042127 |
2017 |
|
Familial Mediterranean Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
An equal proportion of TRAPS patients first received anti-interleukin-1 (anti-IL-1) and anti-tumor necrosis factor (anti-TNF) biologic agents, whereas IL-1 blockade was the main choice for FMF patients resistant to colchicine and MKD/HIDS patients.
|
27723279 |
2017 |
|
Familial Mediterranean Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
The specific IL-1 cytokine instigating development of FMF and the enzymatic caspase involved in its secretion currently are unknown.
|
27998728 |
2017 |
|
Familial Mediterranean Fever
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This study aimed to examine the IL-1β, IL-1ra, and IL-10 cytokine levels in gingival crevicular fluid (GCF) and serum of familial Mediterranean fever (FMF) and chronic periodontitis (CP) patients, and their response to nonsurgical periodontal therapy.
|
27068409 |
2017 |
|
Familial Mediterranean Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
Stress-related mediators (eg, epinephrine) decrease this threshold, leading to autophagy-driven NET release, whereas the synchronous inflammatory environment of FMF attack leads to intracellular production of IL-1β and its release through NETs.
|
28342915 |
2017 |
|
Familial Mediterranean Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
Based on these in vitro analyses, serum concentrations of S100A12, IL-18, and IL-1β were also analyzed in 128 clinically and genetically characterized patients with FMF.
|
27333294 |
2016 |
|
Familial Mediterranean Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
Skin eruption with neutrophil migration in the epidermis may be provoked by T-helper 17 cell activation through the abnormal IL-1β cascade in FMF.
|
26332735 |
2016 |
|
Familial Mediterranean Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
MEFV gene, causing FMF, encodes pyrin that is associated with the interleukin-1 (IL-1) related inflammation cascade.
|
26861613 |
2016 |
|
Familial Mediterranean Fever
|
0.100 |
Biomarker
|
disease |
BEFREE |
The binding of 14-3-3 and PKN proteins to FMF-associated mutant pyrin was substantially decreased, and the constitutive IL-1β release from peripheral blood mononuclear cells of patients with FMF or HIDS was attenuated by activation of PKN1 and PKN2.
|
27270401 |
2016 |