IL1B, interleukin 1 beta, 3553
N. diseases: 1801; N. variants: 22
Source: ALL
| Disease | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year |
|---|---|---|---|---|---|---|---|
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0.100 | GeneticVariation | disease | BEFREE | Helicobacter pylori eradication: influence of interleukin-1beta -31 C/T polymorphism. | 30048609 | 2018 |
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0.100 | Biomarker | disease | BEFREE | Induction of TNF, CXCL8 and IL-1β in macrophages by Helicobacter pylori secreted protein HP1173 occurs via MAP-kinases, NF-κB and AP-1 signaling pathways. | 30267894 | 2018 |
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0.100 | Biomarker | disease | BEFREE | Recent investigations have indicated that produced inflammatory cytokines such as TNF-α and IL-1β in response to gastric infection by Helicobacter pylori play an important role in the development of peptic ulcer. | 29456060 | 2018 |
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0.100 | GeneticVariation | disease | BEFREE | Effect of IL-1β and IL-1RN polymorphisms in carcinogenesis of the gastric mucosa in patients infected with Helicobacter pylori in Algeria. | 27340011 | 2016 |
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0.100 | AlteredExpression | disease | BEFREE | Helicobacter pylori-infected children with ID had significantly increased gastric IL1β mRNA in comparison with infected children without ID. | 26211930 | 2016 |
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0.100 | GeneticVariation | disease | BEFREE | Host genetic factors that control the production of cytokines, including interleukin-1β (IL-1β), possibly affect susceptibility to many Helicobacter pylori-related diseases. | 26188264 | 2015 |
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0.100 | AlteredExpression | disease | BEFREE | Inflammasome activation and caspase-1-dependent (CASP1-dependent) processing and secretion of IL-1β and IL-18 are critical events at the interface of the bacterial pathogen Helicobacter pylori with its host. | 26214524 | 2015 |
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0.100 | Biomarker | disease | BEFREE | OPN KD gastric cancer cell lines also showed lower proliferative activity and reduced MAPK activation than shRNA control cells after HP co-culture or after IL-1β and TNF-α treatment. | 25867766 | 2015 |
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0.100 | GeneticVariation | disease | BEFREE | Genotypes of IL-1β (-511,-31), IL-1RN gene polymorphisms and HP status of the patients were analyzed. | 25910374 | 2014 |
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0.100 | Biomarker | disease | BEFREE | Helicobacter pylori-induced IL-1β secretion in innate immune cells is regulated by the NLRP3 inflammasome and requires the cag pathogenicity island. | 25172489 | 2014 |
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0.100 | Biomarker | disease | BEFREE | Gastric mucosal IL-1β levels were also persistently elevated in group P, and neutralisation of IL-1β reduced the HP-specific IL-17A response of purified CD4(+) T cells to autologous HP-pulsed antigen presenting cells in vitro, suggesting a functional association between IL-1β and the persistent Th17 response in group P patients. | 22761739 | 2012 |
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0.100 | GeneticVariation | disease | BEFREE | Our aim was to explore potential interactions among dietary (chili pepper consumption), infectious (Helicobacter pylori) and genetic factors (IL1B-31 genotypes) on GC risk. | 22414649 | 2012 |
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0.100 | GeneticVariation | disease | BEFREE | Relationship of IL-1 and TNF-α polymorphisms with Helicobacter pylori in gastric diseases in a Brazilian population. | 22714811 | 2012 |
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0.100 | AlteredExpression | disease | BEFREE | Polymorphisms of IL-1 gene cluster are reported to be associated with histological changes and IL-1β expression in the gastric mucosa in adults, especially in Helicobacter pylori-infected subjects. | 21585612 | 2011 |
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0.100 | GeneticVariation | disease | BEFREE | Association of IL1B -511C/-31T haplotype and Helicobacter pylori vacA genotypes with gastric ulcer and chronic gastritis. | 20979650 | 2010 |
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0.100 | PosttranslationalModification | disease | BEFREE | Influence of IL1B polymorphism on CpG island hypermethylation in Helicobacter pylori-infected gastric cancer. | 20405297 | 2010 |
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0.100 | GeneticVariation | disease | BEFREE | Interleukin-1 beta single-nucleotide polymorphism's C allele is associated with elevated risk of gastric cancer in Helicobacter pylori-infected Peruvians. | 19861615 | 2009 |
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0.100 | GeneticVariation | disease | BEFREE | Role of host interleukin 1beta gene (IL-1B) and interleukin 1 receptor antagonist gene (IL-1RN) polymorphisms in clinical outcomes in Helicobacter pylori-positive Turkish patients with dyspepsia. | 18807132 | 2008 |
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0.100 | AlteredExpression | disease | BEFREE | Enhanced gastric IL-18 mRNA expression in Helicobacter pylori-infected children is associated with macrophage infiltration, IL-8, and IL-1 beta mRNA expression. | 18334875 | 2008 |
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0.100 | GeneticVariation | disease | BEFREE | We evaluated the association of functional variants of IL-1 genes with the development of gastritis and precancerous lesions, which are known to be influenced by inflammatory response against Helicobacter pylori. | 18385937 | 2008 |
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0.100 | Biomarker | disease | BEFREE | Furthermore, nucleofection experiments were established to introduce this inhibitory peptide into the nucleus of IL-1 stimulated human cervical and Helicobacter pylori infected gastric epithelial cells. | 18025206 | 2007 |
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0.100 | GeneticVariation | disease | BEFREE | The effects of genetic polymorphisms of IL-1 and TNF-A on Helicobacter pylori-induced gastroduodenal diseases in Korea. | 16579840 | 2006 |
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0.100 | GeneticVariation | disease | BEFREE | Polymorphisms of the IL1B gene have been associated with gastric atrophy and increased cancer risk, especially in Helicobacter pylori-infected subjects. | 16405550 | 2006 |
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0.100 | GeneticVariation | disease | BEFREE | Polymorphism of interleukin-1beta affects the eradication rates of Helicobacter pylori by triple therapy. | 15017629 | 2004 |
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0.100 | Biomarker | disease | BEFREE | IL1B and IL1RN polymorphic genes and Helicobacter pylori cagA strains decrease the risk of reflux esophagitis. | 15236174 | 2004 |