Major Depressive Disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Patients with MDD with melancholic features showed higher IL-1β levels than those without melancholia.
|
31693974 |
2020 |
Major Depressive Disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
CRP and IL-1β levels showed no significant difference between male and female patients in MDD.
|
31629608 |
2019 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
These exploratory findings suggest that IL1-β and, marginally, IL6R polymorphisms may affect treatment response in major depression.
|
31100612 |
2019 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Significantly higher inflammatory biomarkers such as the high sensitivity C-reaktive protein (hsCRP) and proinflammatory acute phase cytokines interleukine-1β (IL-1β) and interleukine-6 (IL-6) underlined the higher cardiovascular risk in physically healthy MDD patients.
|
29895759 |
2018 |
Major Depressive Disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The baseline concentrations of IL-6 and IL-1β (6 h, LPS-) were significantly higher in the MDD group than those in the control group.
|
29587166 |
2018 |
Major Depressive Disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our results suggested that the microstructural changes in IFOF and genu of the corpus callosum are associated with the high IL-1β levels in the early stage of MDD.
|
30069019 |
2018 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
A consistent body of research has confirmed that patients with major depressive disorder (MDD) have increased concentrations of pro-inflammatory cytokines, including IL-6, TNF-α, IL-1β, the soluble IL-2 receptor, and C-reactive protein, compared to controls; however, there is limited information on IL-17A in MDD.
|
29069253 |
2018 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
This review describes previous studies on the genetic effects of IL1B, which relate it to psychiatric diseases such as major depressive disorder, bipolar disorder, schizophrenia, and Alzheimer's disease, as well as cognitive function in normal individuals.
|
28599834 |
2017 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this review, we discuss both preclinical and clinical evidence that links the assembly of the NLRP3 complex and the subsequent proteolysis and release of the pro-inflammatory cytokines interleukin-1β (IL-1β) and interleukin-18 (IL-18) in chronic stress models and patients with MDD.
|
28263786 |
2017 |
Major Depressive Disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Peripheral levels of interleukin-6 (IL-6), tumor necrosis factor (TNF)-alpha, IL-10, the soluble IL-2 receptor, C-C chemokine ligand 2, IL-13, IL-18, IL-12, the IL-1 receptor antagonist, and the soluble TNF receptor 2 were elevated in patients with MDD compared to HCs, whereas interferon-gamma levels were lower in MDD (Hedge's g = -0.477, P = 0.043).
|
28122130 |
2017 |
Major Depressive Disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In the largest study investigating gene expression in children with MDD, we demonstrated that NR3C1, TNF, TNFR1 and IL1B expression levels are related to MDD and conjunctly mediate the effect of CM history on the risk of developing MDD.
|
28384542 |
2017 |
Major Depressive Disorder
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Second, linking these findings to differences in circulating cytokine levels, we show in a separate sample that those with a history of rMDD had higher peripheral levels of IL-33 and IL-1β compared with women with a single MDD episode or no history of MDD.
|
27054346 |
2016 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Controlling for age, sex, and race, IL1B genotype was associated with MDD symptoms (p = .002).
|
25422961 |
2014 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Controlling for age, sex, and race, IL1B genotype was associated with MDD symptoms (p = .002).
|
25422961 |
2014 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Here we examined circulating concentrations of inflammatory cytokines (IFN-γ, TNF-α, IL-1β, IL-6), and the acute phase protein CRP alongside plasma tryptophan, kynurenine, kynurenic acid (KYNA) and 3-hydroxyanthranilic acid (3-HAA) concentrations, and whole blood mRNA expression of IDO, kynurenine aminotransferases (KAT I and II), kynurenine-3-monooxygenase (KMO), kynureninase and SERT in patients with major depressive disorder (MDD) compared with age and sex-matched controls.
|
22683764 |
2012 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To elucidate a genetic predisposition to major depressive disorder, we investigated two polymorphisms (-31T/C and -511C/T) in the interleukin-1beta promoter region in patients who suffered from major recurrent depression.
|
21465264 |
2011 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
The present study suggests a negative effect of the IL1B gene on pharmacological response and amygdala and ACC function involving the same genotypes of two SNPs (rs16944, rs116343), which taken together increase the risk of nonremission over 6 weeks of antidepressant treatment in MDD.
|
20044070 |
2010 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The present study suggests a negative effect of the IL1B gene on pharmacological response and amygdala and ACC function involving the same genotypes of two SNPs (rs16944, rs116343), which taken together increase the risk of nonremission over 6 weeks of antidepressant treatment in MDD.
|
20044070 |
2010 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We genotyped the IL1B -511C/T polymorphism in 125 elderly inpatients diagnosed with major depression and 282 normal elderly controls.
|
19629761 |
2009 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
We genotyped the IL1B -511C/T polymorphism in 125 elderly inpatients diagnosed with major depression and 282 normal elderly controls.
|
19629761 |
2009 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
PSYGENET |
Several lines of evidence implicate the pro-inflammatory cytokine interleukin-1 (IL-1) in the etiology and pathophysiology of major depression.
|
17700577 |
2008 |
Major Depressive Disorder
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Association study of the interleukin-1 beta (C-511T) genetic polymorphism with major depressive disorder, associated symptomatology, and antidepressant response.
|
12700687 |
2003 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
Several lines of evidence indicate that brain cytokines, principally interleukin-1beta (IL-1beta) and IL-1 receptor antagonist may have a role in the biology of major depression, and that they might additionally be involved in the pathophysiology and somatic consequences of depression as well as in the effects of antidepressant treatment.
|
10483047 |
1999 |
Major Depressive Disorder
|
0.400 |
Biomarker
|
disease |
BEFREE |
It is concluded that increased production of IL-6 and IL-1 in major depression may underlie both immune activation and the "acute" phase response in that illness, and that disorders in Hp may be related to the pathophysiology and pathogenesis of major depression.
|
7506108 |
1994 |