|
Autoinflammatory disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Sixty-one patients with SJIA who had received IL-1 blockade were identified within the German Autoinflammatory Disease (AID) registry and DNA biobank.
|
31599092 |
2020 |
|
Autoinflammatory disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The efficacy of colchicine and anti-IL1β-targeted medication in clinical trials indicates that acute and recurrent pericarditis should be regarded as an autoinflammatory disease.
|
30852700 |
2019 |
|
Autoinflammatory disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-1β has emerged as pivotal for promoting inflammation, particularly in autoinflammatory diseases, whereas IL-1α and the IL-36 subfamily are associated with skin diseases.
|
31515542 |
2019 |
|
Autoinflammatory disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
SNPs these proteins were associated with the constructive activation of the Inflammasome and excessive production of IL-1β induce a serious autoinflammatory disease, as sickle cell anemia (SCA).
|
31448710 |
2019 |
|
Autoinflammatory disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Consequently, targeting inflammasomes and IL-1/IL-1R signaling may effectively improve the treatment of Th17-associated disorders, such as autoinflammatory diseases and cancers, thereby providing novel insights into drug development.
|
30739833 |
2019 |
|
Autoinflammatory disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Inflammatory disorders associated with the activation of the NLRP3 inflammasome - IL-1 axis are termed autoinflammatory diseases.
|
30710503 |
2019 |
|
Autoinflammatory disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
A growing experience with the human IL-1 receptor antagonist, Anakinra (ANA), and the monoclonal anti IL-1β antibody, Canakinumab (CANA), has also been engendered, highlighting their efficacy upon protean clinical manifestations of AIDs.
|
30999610 |
2019 |
|
Autoinflammatory disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
This review focuses on updates on molecular pathways and diseases that cause predominantly IL-1β and Type-I IFN-mediated autoinflammatory diseases.
|
30453204 |
2018 |
|
Autoinflammatory disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Until recently the most common autoinflammatory diseases (AIDs) associated with bone disease in childhood included a few genetically complex (chronic non-bacterial osteomyelitis, synovitis, acne, pustulosis, hyperostosis and osteitis syndrome) and monogenic (Majeed syndrome, deficiency of IL-1 receptor antagonist, cherubism) AIDs.
|
28968889 |
2018 |
|
Autoinflammatory disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Because Interleukin-1β (IL-1β) is a key player in autoinflammatory diseases, we compared the ability of IL-1β to activate human dendritic cells and induce immune-regulatory molecules versus the effects induced by pathogen-derived stimuli.
|
29886260 |
2018 |
|
Autoinflammatory disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The putative target genes were validated in patients with STING-associated vasculopathy with onset in infancy (SAVI), a monogenic autoinflammatory disease caused by gain-of-function mutations in TMEM173 that encodes the viral sensor stimulator of IFN genes (STING), and had low expression in clinically active patients with the monogenic IL-1-mediated autoinflammatory disease, neonatal-onset multisystem inflammatory disease (NOMID) and in healthy controls.
|
29638206 |
2018 |
|
Autoinflammatory disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Aberrant endochondral bone formation in the physis is a unique bone lesion in neonatal-onset multisystem inflammatory disease (NOMID), also called chronic infantile neurologic cutaneous articular (CINCA), the most severe of the cryopyrin-associated periodic syndrome (CAPS) diseases, which are interleukin-1β (IL-1β)-related monogenic autoinflammatory diseases.
|
29956067 |
2018 |
|
Autoinflammatory disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Finally, we will discuss how the recent advances of our understanding on the role of IL-1 cytokines in this field may lead to new therapeutic strategies for treatment of common conditions, such as IL-1-driven autoinflammatory diseases.
|
29248003 |
2018 |
|
Autoinflammatory disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Over the past 30 years, IL-1-mediated inflammation has been established in a broad spectrum of diseases, ranging from rare autoinflammatory diseases to common conditions such as gout and rheumatoid arthritis (RA), type 2 diabetes, atherosclerosis, and acute myocardial infarction.
|
30459597 |
2018 |
|
Autoinflammatory disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-1β is a potent player in cutaneous inflammation and central for the development of a Th17 micro-milieu in autoinflammatory diseases including psoriasis.
|
28422993 |
2017 |
|
Autoinflammatory disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pro-inflammatory cytokines such as IL-1β, IL-6 and TNF-α are central regulators of autoinflammatory diseases.
|
27550296 |
2017 |
|
Autoinflammatory disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Further, there are strong indications that classical IL-1-driven autoinflammatory diseases are associated with activation of adaptive immunity.
|
28496446 |
2017 |
|
Autoinflammatory disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, the NLRC3 CARD alone could dampen IL-1β secretion and ASC speck formation induced by NALP3 mutants associated with autoinflammatory diseases.
|
28584053 |
2017 |
|
Autoinflammatory disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition to the recombinant IL-1Ra, anakinra (highly effective in autoinflammatory diseases and tested for other chronic diseases), the monoclonal antibodies canakinumab, gevokizumab, and rilonacept (a long-acting IL-1 receptor fusion protein) provide further options to block IL-1 activity.
|
28798075 |
2017 |
|
Autoinflammatory disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
IL-1β, which is activated by the inflammasome, is known to be central to the pathogenesis of many monogenic autoinflammatory diseases.
|
27994071 |
2017 |
|
Autoinflammatory disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Dysregulated IL-1β Secretion in Autoinflammatory Diseases: A Matter of Stress?
|
28421072 |
2017 |
|
Autoinflammatory disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Familial Mediterranean fever (FMF) is an IL-1β-dependent autoinflammatory disease caused by mutations of Mediterranean fever (MEFV) encoding pyrin and characterized by inflammatory attacks induced by physical or psychological stress.
|
28342915 |
2017 |
|
Autoinflammatory disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recent findings demonstrate a dysregulation of different components of innate immunity during PFAPA flares, such as monocytes, neutrophils, complement, and pro-inflammatory cytokines, especially IL-1β, suggesting an inflammasome-mediated innate immune system activation and supporting the hypothesis of an autoinflammatory disease.
|
26984802 |
2016 |
|
Autoinflammatory disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mutations in the genes encoding pyrin and mevalonate kinase (MVK) cause distinct interleukin-1β (IL-1β)-mediated autoinflammatory diseases: familial Mediterranean fever (FMF) and hyperimmunoglobulinemia D syndrome (HIDS).
|
27270401 |
2016 |
|
Autoinflammatory disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
A recombinant form of the naturally occurring IL-1R antagonist (IL-1Ra), which blocks IL-1R1, is broadly used to treat autoimmune and autoinflammatory diseases; however, blocking IL-1 increases the risk of infection.
|
26157171 |
2015 |