Alzheimer's Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
The current study was designed to investigate which of the inflammasome complexes are critical for IL-1β production in AD.
|
31715312 |
2020 |
Alzheimer's Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
In the current study, we determined the effects of Ampelopsin (AMP) on the levels of proinflammatory cytokines (PICs, IL-1β, IL-6 and TNF-α), and products of oxidative stress 8-isoprostaglandin F2α (8-iso PGF2α, a product of oxidative stress); and 8-hydroxy-2'-deoxyguanosine (8-OHdG, a key biomarker of protein oxidation) in the hippocampus using a rat model of AD.
|
31797758 |
2020 |
Alzheimer's Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Interleukin-1β is a potent proinflammatory cytokine that plays a key role in the pathogenesis of the brain aging and diverse range of neurological diseases including Alzheimer's disease, Parkinson's disease, stroke and persistent pain.
|
31535638 |
2020 |
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
All-trans retinoic acid cotreatment (1 mg/kg BW, i.p. daily) of DSS-treated mice (3% in drinking water for 7 days) alleviated colitis-associated weight loss, diarrheal phenotype, and induction of IL-1β and CXCL1 and a decrease in DRA mRNA and protein levels in the colon.
|
31634391 |
2020 |
Colitis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
A dozen were shown to possess improved properties, among which inhibition of YO-PRO-1/TO-PRO-3 uptake and IL1β release upon BzATP activation of the receptor and dampening signs of DSS-induced colitis on mice, in comparison with reference antagonist GSK1370319A.
|
31525963 |
2020 |
Ulcerative Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our findings established a link between monocyte-like CD163-MNPs, IL-12, IL-1β and the detection of colonic memory IL-8-producing CD4+T cells, which might all contribute to UC pathogenesis.
|
31206576 |
2020 |
Ulcerative Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
The activation of A3AR by 2-Cl-IB-MECA significantly decreased TNF-α and IL-1β production and attenuated the NF-κB p65 activation in colonic tissues from patients with UC.
|
31714673 |
2020 |
Mental Depression
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The hippocampus is particularly vulnerable to altered concentrations of the pro-inflammatory cytokine interleukin-1β (IL-1β), with elevated levels implicated in the aetiology of neurodegenerative disorders such as Alzheimer's and Parkinson's, and stress-related disorders such as depression.
|
31604142 |
2020 |
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
We found that MI triggered NLRP3 inflammasome activation leading to conversion of interleukin-1β (IL-1β) and IL-18 into their active mature forms in the heart, which could expand the infarct size and drive cardiac dysfunction.
|
31645662 |
2020 |
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
Cases had higher levels of IL-1Ra at all time-points leading up to first-time MI, and higher levels of IL-1Ra were associated with approximately 1.5-fold increased risk of MI, supporting the rationale to target IL-1 activation in order to reduce cardiovascular risk in PWH.
|
31077280 |
2020 |
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
Recently, the CANTOS (Canakinumab Anti-Inflammatory Thrombosis Outcomes Study) showed the successful anti-inflammatory benefit of canakinumab, a monoclonal antibody targeting interleukin-1ß (IL-1ß) toward major cardiovascular events (MACE) in patients with a previous myocardial infarction (MI).
|
31469975 |
2020 |
Myocardial Infarction
|
0.600 |
Biomarker
|
disease |
BEFREE |
All in all, miR-132 inhibits cardiomyocyte apoptosis so as to ameliorate myocardial remodeling in rats with MI through IL-1β downregulation.
|
31621911 |
2020 |
Pneumonia
|
0.600 |
Biomarker
|
disease |
BEFREE |
We hypothesized that TLMPs trigger inflammasome activation and IL-1β production in bronchial and alveolar epithelial cells to induce airway and lung inflammation.
|
31759058 |
2020 |
Pneumonia
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Intratracheal instillation of nZnO intensively aggravated LPS-induced lung inflammation that was accompanied by enhanced expression of interleukin-1β, interleukin-6, monocyte chemotactic protein-1αand granulocyte-macrophage colony stimulating factor.
|
31804693 |
2020 |
Alzheimer's Disease
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In the current report, we determined the effects of microRNA-155 (miR-155) on the levels of IL-1β, IL-6 and TNF-α, and their respective receptors in the hippocampus using a rat model of AD.
|
31456514 |
2019 |
Alzheimer's Disease
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
CCH strongly enhanced NLRP3, activated caspase-1 and IL-1β expressions in hippocampus and thalamus at age 12 M of AD mice.
|
29885344 |
2019 |
Alzheimer's Disease
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
A total of 170 studies were included in the meta-analysis and systematic review, which demonstrated increased peripheral levels of high-sensitivity C reactive protein (Hedges's g 0.281, p<0.05), interleukin-6 (IL-6) (0.429, p<0.005), soluble tumour necrosis factor receptor 1 (sTNFR1) (0.763, p<0.05), soluble tumour necrosis factor receptor 2 (sTNFR2) (0.354, p<0.005), alpha1-antichymotrypsin (α1-ACT) (1.217, p<0.005), IL-1β (0.615, p<0.05) and soluble CD40 ligand (0.868, p<0.005), and CSF levels of IL-10 (0.434, p<0.05), monocyte chemoattractant protein-1 (MCP-1) (0.798, p<0.005), transforming growth factor-beta 1 (1.009, p<0.05), soluble triggering receptor expressed on myeloid cells2 (sTREM2) (0.587, p<0.001), YKL-40 (0.849, p<0.001), α1-ACT (0.638, p<0.001), nerve growth factor (5.475, p<0.005) and visinin-like protein-1 (VILIP-1) (0.677, p<0.005), in AD compared with the control.
|
30630955 |
2019 |
Alzheimer's Disease
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Moreover, apelin-13 inhibited microglia and astrocyte activation, reduced IL-1β and TNF-α expression and hippocampal BDNF/TrkB expression deficit in AD rats.
|
31040784 |
2019 |
Alzheimer's Disease
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
This study measured amyloid-beta (Aβ), interleukin-1 beta (IL-1β), and glial fibrillary acidic protein (GFAP) expression in the hippocampus of Alzheimer's disease (AD) rat models to elucidate the mechanism of anti-inflammatory effect of ginsenoside Rb1 in AD.
|
31217866 |
2019 |
Alzheimer's Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Furthermore, THS reduced mRNA expression of the proinflammatory cytokines, TNF-α, IL-6, and IL-1β and increased synapse-associated proteins (synaptophysin and postsynaptic density protein 95) in the hippocampus of AD mice.
|
31244052 |
2019 |
Alzheimer's Disease
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The db mutation also reduced the cortical IL-1β mRNA level and IBA1 protein level in young AD mice, with no significant effect on the activation of microglia and astrocytes.
|
31034991 |
2019 |
Alzheimer's Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Defects in interleukin-1β (IL-1β)-mediated cellular responses contribute to Alzheimer's disease (AD).
|
31570577 |
2019 |
Alzheimer's Disease
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In the AD model group, the inhibition of PC12 cell growth was significantly increased, and the mRNA expression levels of IL‑1β, IL‑6, TNF‑α and MIF were also increased.
|
31322215 |
2019 |
Alzheimer's Disease
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Increased expression of IL-1β and iron accumulation have been identified in microglial cells that cluster around amyloid plaques in AD mouse models and post-mortem brain tissues of AD patients.
|
31693761 |
2019 |
Alzheimer's Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our data showed that SEO improved the cognitive ability of mice with Aβ<sub>1-42</sub> or lipopolysaccharides (LPS)-induced Alzheimer's disease (AD) and suppressed the production of tumor necrosis factor-a (TNF-a), interleukin-6 (IL-6), and interleukin-1β (IL-1β) in the hippocampus.
|
31463498 |
2019 |