IL1R1, interleukin 1 receptor type 1, 3554

N. diseases: 184; N. variants: 40
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1527304
Disease: Allergic Reaction
Allergic Reaction 		0.400 GeneticVariation phenotype GWASDB A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci. 23817569 2013
CUI: C1527304
Disease: Allergic Reaction
Allergic Reaction 		0.400 Biomarker phenotype CTD_human Expansion of CD4(+) CD25(+) and CD25(-) T-Bet, GATA-3, Foxp3 and RORγt cells in allergic inflammation, local lung distribution and chemokine gene expression. 21625544 2011
CUI: C0014175
Disease: Endometriosis
Endometriosis 		0.340 Biomarker disease CTD_human Molecular evidence for differences in endometrium in severe versus mild endometriosis. 21063030 2011
CUI: C0014175
Disease: Endometriosis
Endometriosis 		0.340 Biomarker disease CTD_human Unique transcriptome, pathways, and networks in the human endometrial fibroblast response to progesterone in endometriosis. 20864642 2011
CUI: C0014175
Disease: Endometriosis
Endometriosis 		0.340 AlteredExpression disease LHGDN The decrease in IL1R2 mRNA levels in eutopic endometrial tissue of endometriosis women, and the concomitant increase in IL1R1 mRNA levels in ectopic implants, reveal a profound defect in IL1R 1 and IL1R2 gene expression which may accentuate the capability of this tissue to respond to IL1 and favor its ectopic growth. 17517439 2008
CUI: C0014175
Disease: Endometriosis
Endometriosis 		0.340 AlteredExpression disease BEFREE The decrease in IL1R2 mRNA levels in eutopic endometrial tissue of endometriosis women, and the concomitant increase in IL1R1 mRNA levels in ectopic implants, reveal a profound defect in IL1R 1 and IL1R2 gene expression which may accentuate the capability of this tissue to respond to IL1 and favor its ectopic growth. 17517439 2008
CUI: C0014175
Disease: Endometriosis
Endometriosis 		0.340 AlteredExpression disease BEFREE Our study showed an imbalance in the expression of IL1R1 and IL1R2 in eutopic, and particularly in ectopic, endometrial tissues of women with endometriosis. 17324958 2007
CUI: C0014175
Disease: Endometriosis
Endometriosis 		0.340 AlteredExpression disease LHGDN Actually, a decreased IL1R2 expression is predominant in the eutopic and ectopic endometrium of women with endometriosis when compared with normal women, whereas a concomitant increase in IL1R1 expression occurs in ectopic endometrial tissue in comparison to eutopic endometrial tissue of normal or endometriotic women, particularly in the initial and most active implants. 17324958 2007
CUI: C0014175
Disease: Endometriosis
Endometriosis 		0.340 GeneticVariation disease LHGDN Polymorphisms in exons 1B and 1C of the type I interleukin-1 receptor gene in patients with endometriosis. 16911713 2006
CUI: C0014175
Disease: Endometriosis
Endometriosis 		0.340 AlteredExpression disease LHGDN Down-regulation of interleukin-1 receptor type 1 expression causes the dysregulated expression of CXC chemokines in endometriotic stromal cells: a possible mechanism for the altered immunological functions in endometriosis. 15472211 2004
CUI: C0014175
Disease: Endometriosis
Endometriosis 		0.340 AlteredExpression disease BEFREE Down-regulation of interleukin-1 receptor type 1 expression causes the dysregulated expression of CXC chemokines in endometriotic stromal cells: a possible mechanism for the altered immunological functions in endometriosis. 15472211 2004
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.320 GeneticVariation disease BEFREE The present study analyzed potential relationships between alcoholism or alcoholic liver disease (ALD) and IL12B 2124 G>T (rs1368439), IL16 5000 C>T (rs1131445), IL1R1 3114 C>T (rs3917328), and NFKB1 3400 A>G (rs4648143) polymorphisms. 29566963 2018
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.320 GeneticVariation disease BEFREE We did not find any association of alcoholism or ALD with polymorphisms in the IL1A and IL1R1 genes. 15797878 2005
CUI: C3714636
Disease: Pneumonitis
Pneumonitis 		0.310 Biomarker disease BEFREE Circulating biomarker analyses demonstrated increases in CXCR2, IL1ra and IL2ra that coincided with the development of symptomatic pneumonitis. 31014385 2019
CUI: C3714636
Disease: Pneumonitis
Pneumonitis 		0.310 Biomarker disease CTD_human Expansion of CD4(+) CD25(+) and CD25(-) T-Bet, GATA-3, Foxp3 and RORγt cells in allergic inflammation, local lung distribution and chemokine gene expression. 21625544 2011
CUI: C0037274
Disease: Dermatologic disorders
Dermatologic disorders 		0.300 Biomarker group CTD_human Toxicogenomic analysis of chlorine vapor-induced porcine skin injury. 22533443 2012
CUI: C0020517
Disease: Hypersensitivity
Hypersensitivity 		0.300 Biomarker group CTD_human Expansion of CD4(+) CD25(+) and CD25(-) T-Bet, GATA-3, Foxp3 and RORγt cells in allergic inflammation, local lung distribution and chemokine gene expression. 21625544 2011
CUI: C0032285
Disease: Pneumonia
Pneumonia 		0.300 Biomarker disease CTD_human Expansion of CD4(+) CD25(+) and CD25(-) T-Bet, GATA-3, Foxp3 and RORγt cells in allergic inflammation, local lung distribution and chemokine gene expression. 21625544 2011
CUI: C0032300
Disease: Lobar Pneumonia
Lobar Pneumonia 		0.300 Biomarker disease CTD_human Expansion of CD4(+) CD25(+) and CD25(-) T-Bet, GATA-3, Foxp3 and RORγt cells in allergic inflammation, local lung distribution and chemokine gene expression. 21625544 2011
CUI: C0269102
Disease: Endometrioma
Endometrioma 		0.300 Biomarker disease CTD_human Molecular evidence for differences in endometrium in severe versus mild endometriosis. 21063030 2011
CUI: C0269102
Disease: Endometrioma
Endometrioma 		0.300 Biomarker disease CTD_human Unique transcriptome, pathways, and networks in the human endometrial fibroblast response to progesterone in endometriosis. 20864642 2011
CUI: C0887898
Disease: Experimental Lung Inflammation
Experimental Lung Inflammation 		0.300 Biomarker disease CTD_human Expansion of CD4(+) CD25(+) and CD25(-) T-Bet, GATA-3, Foxp3 and RORγt cells in allergic inflammation, local lung distribution and chemokine gene expression. 21625544 2011
CUI: C0011854
Disease: Diabetes Mellitus, Insulin-Dependent
Diabetes Mellitus, Insulin-Dependent 		0.240 GeneticVariation disease BEFREE Our findings indicate that the VDR FokI polymorphism and several VDR and IL-1-R1 haplotypes are associated with susceptibility to T1DM in the Dalmatian population. 16258158 2005
CUI: C0011854
Disease: Diabetes Mellitus, Insulin-Dependent
Diabetes Mellitus, Insulin-Dependent 		0.240 Biomarker disease MGD IL-1 receptor deficiency slows progression to diabetes in the NOD mouse. 14693705 2004
CUI: C0011854
Disease: Diabetes Mellitus, Insulin-Dependent
Diabetes Mellitus, Insulin-Dependent 		0.240 GeneticVariation disease BEFREE Characterization of new polymorphisms in the 5' UTR of the human interleukin-1 receptor type 1 (IL1R1) gene: linkage to type 1 diabetes and correlation to IL-1RI plasma level. 11197691 2000