|
Malignant neoplasm of stomach
|
0.500 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Malignant neoplasm of stomach
|
0.500 |
Biomarker
|
disease |
HPO |
|
|
|
|
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
IL1RN 2R/2R genotype [odds ratio (OR) 2.43; 95% confidence interval (CI) 1.19-4.96] and allele IL1RN Ex5-35C were associated with an increased risk of Hp(+) non-cardia GC.
|
18628242 |
2008 |
|
Malignant neoplasm of stomach
|
0.500 |
Biomarker
|
disease |
BEFREE |
IL-1RA has the potential to play a role in the treatment of gastric cancer.
|
29344744 |
2018 |
|
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A comprehensive analysis of 207 SNP of 11 cytokine genes revealed that variations in IL-4 and IL-1RN genes are negatively associated with the risk of developing gastric cancer following H. pylori infection.
|
17444864 |
2007 |
|
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Although no correlation was found in the analysis of the IL-1B and IL-1RN polymorphisms, IL-8 -251 A/A genotype held a higher risk of atrophic gastritis [odds ratio (OR), 2.35; 95% confidence interval (CI), 1.12-4.94] and gastric cancer (OR, 2.22; 95% CI, 1.08-4.56) compared with the T/T genotype.
|
16284368 |
2005 |
|
Malignant neoplasm of stomach
|
0.500 |
Biomarker
|
disease |
BEFREE |
An epistatic interrelationship between IL-1beta -511 and IL-1RN confers protection against gastric cancer in low-risk Italian population.
|
15927855 |
2005 |
|
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Atrophic body gastritis patients harbouring the wild type of IL-1B-511/IL-1RN polymorphisms were not different from those harbouring the proinflammatory pattern as far as regards gender, age, gastric cancer family history and metaplastic atrophy.
|
18047563 |
2008 |
|
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Carriers of IL-1 1B- 511T and IL-1RN*2 homozygotes have an increased risk of developing gastric cancer.
|
12530098 |
2003 |
|
Malignant neoplasm of stomach
|
0.500 |
Biomarker
|
disease |
BEFREE |
For the associations between IL-1RN and gastric cancer, ORs (95% CIs) for *2/L versus LL and *2/*2 versus L/L were 1.15 (0.96-1.38) and 1.23 (0.79-1.92).
|
17035400 |
2006 |
|
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Haplotypes established from the three polymorphisms of IL-1RN were not associated with a risk of GC.
|
24080970 |
2014 |
|
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
IL-1B and IL-1RN polymorphisms were investigated in 138 H. pylori-negative Italian patients with sporadic gastric cancer and 100 H. pylori-negative controls.
|
15851404 |
2005 |
|
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
IL-1B-511T and IL-1RN *2 were associated with risks of gastric cancer.
|
18565646 |
2008 |
|
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, IL-1B-511 and IL-1RN genetic polymorphisms are associated with an increased risk of developing gastric cancer.
|
17096351 |
2007 |
|
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In this retrospective cohort study we genotyped 154 patients with gastric cancer for IL-1β and IL-1RN variations.
|
24557417 |
2015 |
|
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Interleukin-1beta and interleukin-1 receptor antagonist gene polymorphisms and gastric cancer: a meta-analysis.
|
16985030 |
2006 |
|
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Multivariate regression analysis showed that cagE, babA2, and IL-1RN-1/2 genotypes were independent predictors of GC, but when patients with benign disorders were grouped together (NUD + DU) and compared with patients with GC, regression analysis disclosed that babA2 (P = 0.000) and IL-1B-31 gene polymorphisms (CC or CT) (P = 0.01) were the only independent markers of GC.
|
18807132 |
2008 |
|
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our findings indicate that the IL-1B and IL-1RN polymorphisms are associated with the development of GC and H. pylori infection markedly increases the risk of GC in North Indian population.
|
19607807 |
2009 |
|
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our results did not support the previous report that IL-1B -31 C/IL-1RN*2 polymorphisms were associated with an increased risk of gastric cancer.
|
12788304 |
2003 |
|
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our study investigates the role of the IL-1B-31, IL-1RN and TNF-A-308 gene polymorphisms as risk factors for the development of GC in a Mexican population.
|
15540224 |
2005 |
|
Malignant neoplasm of stomach
|
0.500 |
Biomarker
|
disease |
BEFREE |
Polymorphisms of the IL-1B and IL-1RN genes (which encode interleukin [IL]-1beta and IL-1 receptor antagonist, respectively) have been associated with hypochlorhydria and gastric cancer.
|
12854083 |
2003 |
|
Malignant neoplasm of stomach
|
0.500 |
Biomarker
|
disease |
BEFREE |
Previously we have shown that the known proinflammatory genotypes, IL-1B -31C/+ and IL-1RN *2/*2, were not associated with increased risks for gastric cancer/duodenal ulcer in the Korean population.
|
15381184 |
2004 |
|
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Prognostic role of interleukin-1beta gene and interleukin-1 receptor antagonist gene polymorphisms in patients with advanced gastric cancer.
|
15800325 |
2005 |
|
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
So, our results indicated that the IL-1RN*2 allele may increase the risk of gastric cancer and precancerous lesions in the Southeast Brazilian population, reinforcing the importance of host genetic factors in the susceptibility to gastric cancer and the participation of cytokines in both the inflammation and the carcinogenic process.
|
22327782 |
2012 |
|
Malignant neoplasm of stomach
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Synergistic effect of H. pylori infection and IL-1B-511*T/IL-1RN*2 genotypes was also observed in association with significantly higher risk of developing GC.
|
28110439 |
2017 |