|
Coronary heart disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
We examined a comprehensive array of pro-(IL-2, IL-6, IL-8, IL-18, IL-1β, TNF-α, IFN-γ), and anti-inflammatory (IL-10 and IL-1ra) mediators, cytokines involved in inflammation in response to hypoxia (EPO), propagating angiogenesis (VEGF), and myelopoiesis (GM-CSF), by enzyme linked immunosorbent assay (ELISA), as well as discussing the potential impact of significant CHD and Lipopolysaccharide endotoxin on these mediators.
|
31785499 |
2020 |
|
Coronary heart disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Prognostic impact of Interleukin-1 receptor antagonist in patients with documented coronary artery disease.
|
29395365 |
2018 |
|
Coronary heart disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The allele count of the genetic score had roughly log-linear, dose-dependent associations with both IL-1Ra concentration and risk of coronary heart disease.
|
25726324 |
2015 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the population of 113 subjects for this study, those with the minor C allele of rs4251961 polymorphism in IL1RN were more likely to be Caucasian, hypertensive, and to be afflicted with coronary heart disease.
|
24233813 |
2014 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Similarly, there was no association between IL-1RN VNTR polymorphism and CHD risk (*2 vs. L: OR = 1.00, 95%CI 0.85-1.17).
|
23029154 |
2012 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Allele 1 of IL-1RN VNTR may be associated with the coexistence of CHD and PE in a multiple regression model.
|
19053923 |
2008 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Prognostic value of interleukin-1 receptor antagonist gene polymorphism and cytomegalovirus seroprevalence in patients with coronary artery disease.
|
15943888 |
2005 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
In 160 patients with coronary heart disease (CHD) confirmed by angiography, we examined the relationship between CRP level and five polymorphisms in genes coding for these cytokines: IL-1B(-511), IL-1B(+3954), a variable number tandem repeat (VNTR) polymorphism in intron 2 of IL-1RN [IL-1RN(VNTR)], IL-6(-174) and IL-6(-572).
|
15379752 |
2004 |
|
Coronary heart disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The IL1RN*2 phenotype is associated with ulcerative colitis and Crohn's disease, lupus erythematosus, vulvar vestibulitis, and possibly with osteoporosis and coronary artery disease.
|
11740709 |
2002 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
While an interleukin-1 receptor antagonist gene polymorphism (IL1RN-VNTR) has recently been hypothesized to be a risk factor for coronary artery disease, no prospective data relating this polymorphism to subsequent risk of coronary events are available.
|
11816697 |
2001 |
|
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Interleukin-1 receptor antagonist gene polymorphism and coronary artery disease.
|
10027806 |
1999 |