IL1RN, interleukin 1 receptor antagonist, 3557

N. diseases: 701; N. variants: 52
Disease: Duodenal Ulcer ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0013295
Disease: Duodenal Ulcer
Duodenal Ulcer 		0.100 Biomarker disease BEFREE In conclusion, our meta-analysis suggests that there is no evidence of significant association between IL-1RN VNTR and DU with or without Helicobacter pylori infection in overall population, whereas significant association is found by subgroup analyses which showed protective effect of IL-1RN allele 2 against DU risk in Caucasian population. 23800434 2013
CUI: C0013295
Disease: Duodenal Ulcer
Duodenal Ulcer 		0.100 Biomarker disease BEFREE These findings show that no evidence for the involvement of a proinflammatory polymorphism in the IL-1Beta-511, IL-1RN and TNF-A-308 in the susceptibility to DU in China. 19804405 2010
CUI: C0013295
Disease: Duodenal Ulcer
Duodenal Ulcer 		0.100 GeneticVariation disease BEFREE IL-1B-511, IL-1RN, and IL-2 genetic polymorphisms were not important contributors to the pathogenesis of GU, GC, and DU in Korean patients. 18761558 2008
CUI: C0013295
Disease: Duodenal Ulcer
Duodenal Ulcer 		0.100 GeneticVariation disease BEFREE Three hundred and ninety-nine patients with gastroduodenal diseases (129 chronic gastritis, 127 duodenal ulcer and 143 non-cardiac gastric cancer) and 264 healthy controls were genotyped for IL-1B-511 and IL-1RN gene polymorphisms by the PCR-RFLP method. 17295877 2007
CUI: C0013295
Disease: Duodenal Ulcer
Duodenal Ulcer 		0.100 GeneticVariation disease BEFREE In the present study, 310 individuals from Eastern India were subjected to a case-control study to determine the IL1B and IL1RN risk genotypes to H. pylori mediated duodenal ulcer. 16550552 2006
CUI: C0013295
Disease: Duodenal Ulcer
Duodenal Ulcer 		0.100 Biomarker disease BEFREE Because gastric cancer and duodenal ulcer are mutually exclusive outcomes of Helicobacter pylori infection, we aimed to investigate possible allelic variant associations of several functional polymorphisms in the IL-1B, IL-1RN, TNFA, and LTA genes in the susceptibility to duodenal ulcer. 16164697 2005
CUI: C0013295
Disease: Duodenal Ulcer
Duodenal Ulcer 		0.100 AlteredExpression disease BEFREE However, increasing age, male sex, and IL1RN*2 were independently associated with duodenal ulcer. 16183821 2005
CUI: C0013295
Disease: Duodenal Ulcer
Duodenal Ulcer 		0.100 Biomarker disease BEFREE Our data indicate that H. pylori infection and IL-1RN*2 synergistically determine susceptibility to duodenal ulcer. 15610073 2004
CUI: C0013295
Disease: Duodenal Ulcer
Duodenal Ulcer 		0.100 Biomarker disease LHGDN Our data indicate that H. pylori infection and IL-1RN*2 synergistically determine susceptibility to duodenal ulcer. 15610073 2004
CUI: C0013295
Disease: Duodenal Ulcer
Duodenal Ulcer 		0.100 GeneticVariation disease BEFREE In addition, the simultaneous carriage of IL-1RN*2, IL-1B-511*C, IL-1B-31*T and IL-1B + 3954*C alleles was a genetic risk factor for DU in patients with H. pylori infection (OR: 3.22; 95%CI = 1.09-9.47). 14632761 2003
CUI: C0013295
Disease: Duodenal Ulcer
Duodenal Ulcer 		0.100 GeneticVariation disease BEFREE Similarly, IL-1RN*2 was not a risk genotype for either gastric cancer or duodenal ulcer. 12788304 2003
CUI: C0013295
Disease: Duodenal Ulcer
Duodenal Ulcer 		0.100 GeneticVariation disease BEFREE Carriage of IL-1RN allele 2 significantly protected against DU disease while the IL-1B-511 T/T genotype significantly protected against DU recurrence in patients older than 60 years. 12105837 2002
CUI: C0013295
Disease: Duodenal Ulcer
Duodenal Ulcer 		0.100 GeneticVariation disease BEFREE Logistic regression identified H. pylori infection and NSAIDs use as independent risk factors for peptic ulcer diseases whereas the simultaneous carriage of IL-1B(+3954) allele 2 and IL-1RN allele 2 was associated with reduced risk for duodenal ulcer disease (OR: 0.37, 95% CI = 0.14-0.9). 11531943 2001