|
Schizophrenia
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest that the cytokine IL-1Ra may play a role in SCZ pathophysiology.
|
30375100 |
2019 |
|
Schizophrenia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our study supports that IL-1ra and NCAM-1/CD56 may be considered as markers of developing SZ.
|
29898582 |
2018 |
|
Schizophrenia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
At baseline, IL-1ra and MCP-1 levels in schizophrenia were significantly higher than health controls (t = 4.55, P = 0.0001, t = 3.08 P = 0.003).
|
29410009 |
2018 |
|
Schizophrenia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Persistently increased sTNF-R1 and IL-1Ra after one year in patients with severe mental disorders primarily reflecting data from the schizophrenia group may suggest that inflammation is a trait phenomenon, and not only the result of stress-related mechanisms associated with acute episodes.
|
28815548 |
2017 |
|
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Haplotype CT (rs4251961, rs419598) in IL1RN was found to be associated with schizophrenia.
|
28083609 |
2016 |
|
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of the present study was first to test for a possible role of serum leptin and adiponectin levels as a marker of weight gain in association with inflammatory cytokines/adipokines (IL-6, IL-1Ra, hs-CRP and adipsin), and second to study associations between SNPs LEP rs7799039 (-2548 A/G), ADIPOQ rs1501299 and HTR2C rs1414334 and weight gain and levels of leptin and adiponectin, in 190 patients with schizophrenia on clozapine treatment, with retrospectively assessed weight change and cross-sectionally measured cytokine levels.
|
25284335 |
2015 |
|
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Neither combined nor stratified analyses found any association of the rs1800587 (IL1A gene; T-889C) or rs1794068 (IL1RA Gene; IL1RN_86 bp; T/C) with schizophrenia susceptibility.
|
20347268 |
2010 |
|
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association study of IL10, IL1beta, and IL1RN and schizophrenia using tag SNPs from a comprehensive database: suggestive association with rs16944 at IL1beta.
|
16905295 |
2006 |
|
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Ventricular enlargement in schizophrenia is associated with a genetic polymorphism at the interleukin-1 receptor antagonist gene.
|
16019233 |
2005 |
|
Schizophrenia
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study indicates that IL-1RA could be a candidate gene for susceptibility to schizophrenia.
|
15318032 |
2004 |
|
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Moreover our data show a protective effect of the IL-1RA allele 2 (86bp)(2) against schizophrenia (OR=0.59 95%CI:0.388-0.910; P=0.016) and this effect is enhanced by the concomitant presence of IL-1beta -511T (OR=0.48 95%CI:0.30-0.76; P=0.002).
|
14563376 |
2004 |
|
Schizophrenia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
To evaluate the contribution of IL-1 signaling to the brain pathology of schizophrenia, we measured protein and/or mRNA levels for IL-1beta and endogenous IL-1 receptor antagonist (IL-1RA) in the postmortem brain tissues of prefrontal and parietal cortex, putamen, and hypothalamus.
|
12804791 |
2003 |