|
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Circulating concentrations of CRP, PCT, interleukin (IL)-10 and IL-1 receptor antagonist (IL-1Ra) were significantly higher in patients with sepsis, with IL-10 identified as the best biomarker in differentiating sepsis from SIRS.
|
31125901 |
2019 |
|
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Results from some positive randomized controlled trials, for example, studies of recombinant activated protein C, talactoferrin, interleukin-1 receptor antagonist in sepsis, and muscle relaxants in severe acute respiratory distress syndrome were not replicated in subsequent randomized controlled trials.
|
31567349 |
2019 |
|
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Using 2003-2013 data from the Chronic Renal Insufficiency Cohort Study (3,597 participants with CKD), we assessed the association of baseline plasma levels of four inflammatory markers (interleukin-6 [IL-6], tumor necrosis factor-α [TNF-α], interleukin-1 receptor antagonist [IL-1RA], and transforming growth factor-β [TGF-β]), with incident hospitalization with major infection (pneumonia, urinary tract infection, cellulitis and osteomyelitis, and bacteremia and sepsis).
|
31673705 |
2019 |
|
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Interleukin-1 receptor antagonist as a biomarker of sepsis in neutropenic haematological patients.
|
30099772 |
2018 |
|
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Mortality Benefit of Recombinant Human Interleukin-1 Receptor Antagonist for Sepsis Varies by Initial Interleukin-1 Receptor Antagonist Plasma Concentration.
|
28991823 |
2018 |
|
Sepsis
|
0.300 |
Biomarker
|
disease |
BEFREE |
The effect of the pre-treatment on protein expression was most clearly seen for IL-1β and iNOS at 24 h. Our results showed that blocking the IL-1-IL-1r signaling pathway by central administration of an IL-1ra decreases hypothalamic oxidative stress markers during sepsis.
|
26184633 |
2016 |
|
Sepsis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
According to the results of our meta-analysis, the IL1RN 86-bp VNTR polymorphism probably associates with sepsis risk but not with sepsis-related mortality.
|
25500257 |
2015 |
|
Sepsis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Our meta-analysis indicated that IL-1A-889, IL-1B + 3954 and IL-1RN VNTR might be associated with sepsis susceptibility.
|
24428862 |
2014 |
|
Sepsis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The aim of the study was to determine whether distributions of tumor necrosis factor (TNF)-α(308), interleukin (IL)-10(1082), CD14(159), and IL-1ra gene intron 2 genotypes in critically ill patients are associated with outcome, underlying cause of sepsis, and type of microorganism.
|
20163933 |
2010 |
|
Sepsis
|
0.300 |
GeneticVariation
|
disease |
LHGDN |
Interleukin-1 receptor antagonist gene polymorphism and mortality in patients with severe sepsis.
|
11876758 |
2002 |
|
Sepsis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
In contrast to the TNF-beta NcoI polymorphism, which has been associated with patients' nonsurvival, the allele IL-1raA2 of the polymorphism within the intron 2 of IL-1ra may contribute to susceptibility to sepsis.
|
10446828 |
1999 |
|
Sepsis
|
0.300 |
Biomarker
|
disease |
RGD |
Induction of pituitary cytokine transcripts by peripheral lipopolysaccharide.
|
10048466 |
1999 |