IL1RN, interleukin 1 receptor antagonist, 3557
N. diseases: 701; N. variants: 52
Source: ALL
| Disease | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year |
|---|---|---|---|---|---|---|---|
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0.100 | GeneticVariation | disease | BEFREE | Effect of IL-1β and IL-1RN polymorphisms in carcinogenesis of the gastric mucosa in patients infected with Helicobacter pylori in Algeria. | 27340011 | 2016 |
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0.100 | GeneticVariation | disease | BEFREE | Genotypes of IL-1β (-511,-31), IL-1RN gene polymorphisms and HP status of the patients were analyzed. | 25910374 | 2014 |
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0.100 | GeneticVariation | disease | BEFREE | Residence during childhood, socioeconomic status, and smoking habits were investigated as environmental factors, Helicobacter pylori (H. pylori) virulence factors (cagA, vagA s1 and m1 regions, and oipA) were evaluated, and seven biallelic polymorphisms (IL-1B-511, TNF-A-308, IL-6-572, IL-8-251, IL-10-592, IL-10-1082, and TGFB1-509) and IL-1RN variable number of tandem repeats were genotyped. | 21502924 | 2011 |
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0.100 | GeneticVariation | disease | BEFREE | Role of host interleukin 1beta gene (IL-1B) and interleukin 1 receptor antagonist gene (IL-1RN) polymorphisms in clinical outcomes in Helicobacter pylori-positive Turkish patients with dyspepsia. | 18807132 | 2008 |
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0.100 | GeneticVariation | disease | BEFREE | IL1RN 2R/2R genotype [odds ratio (OR) 2.43; 95% confidence interval (CI) 1.19-4.96] and allele IL1RN Ex5-35C were associated with an increased risk of Hp(+) non-cardia GC. | 18628242 | 2008 |
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0.100 | AlteredExpression | disease | BEFREE | Sera were used for the measurement of pepsinogen (PG) and Helicobacter pylori CagA antibody (CagA-ab) levels by ELISA, and human genomic DNAs were used for the genotyping of interleukin (IL)-1beta (-511 and +3954), IL-10 (-1082 and -592), and IL-1RN intron 2 by PCR and RFLP. | 18086767 | 2007 |
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0.100 | Biomarker | disease | BEFREE | The aim of this study was to evaluate whether there was any correlation between Helicobacter pylori-associated diseases and (1) H. pylori virulence genes or (2) IL-1B, IL-1RN, IFN-G, TNF-A, IL-10 genetic polymorphisms. | 15652446 | 2005 |
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0.100 | GeneticVariation | disease | BEFREE | Interleukin 1B gene (IL-1B) and interleukin 1 receptor antagonist gene (IL-1RN) polymorphisms in Helicobacter pylori-negative gastric cancer of intestinal and diffuse histotype. | 15851404 | 2005 |
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0.100 | GeneticVariation | disease | BEFREE | IL1RN polymorphism and cagA-positive Helicobacter pylori strains increase the risk of duodenal ulcer in children. | 16183821 | 2005 |
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0.100 | GeneticVariation | disease | BEFREE | IL1B and IL1RN polymorphic genes and Helicobacter pylori cagA strains decrease the risk of reflux esophagitis. | 15236174 | 2004 |
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0.100 | GeneticVariation | disease | BEFREE | IL-1 RN 2/2 genotype and simultaneous carriage of genotypes IL-1 RN 2/2 and IL-1beta-511 T/T associated with oesophagitis in Helicobacter pylori-negative patients. | 14750640 | 2003 |
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0.100 | GeneticVariation | disease | BEFREE | Pro-inflammatory polymorphisms within the genes interleukin (IL)-1B and IL-1RN are associated with risk for gastric carcinoma (GC) in Helicobacter pylori-infected individuals. | 12891537 | 2003 |
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0.100 | Biomarker | disease | BEFREE | Helicobacter pylori virulence genes and host IL-1RN and IL-1beta genes interplay in favouring the development of peptic ulcer and intestinal metaplasia. | 12161099 | 2002 |
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0.100 | GeneticVariation | disease | BEFREE | We determined IL-1B-511/-31 and IL-1RN genotypes and measured gastric juice pH, serum pepsinogen (PG) I and II levels, and gastritis and atrophy scores in Helicobacter pylori-positive patients with gastritis only, gastric ulcers, or duodenal ulcers (DUs), and H. pylori-negative controls. | 12105837 | 2002 |
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0.100 | GeneticVariation | disease | BEFREE | This study aims to examine the infection rate of HP according to gene polymorphisms of interleukin (IL)-1A, IL-1B, and IL-1RN, and to investigate the interactions with lifestyle factors. | 11346459 | 2001 |