|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
We also report low numbers of resting CD4(+) CD25(+) T cells in IMD patients, a subset of T cells shown to have important immunoregulatory functions in abrogating autoimmunities in 3-day thymectomized experimental mice.
|
11781358 |
2002 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
CD4+CD25+ regulatory T cells were first described in experimental autoimmune gastritis and there has been a recent explosion of interest in the potential role of these immunoregulatory T cells in protection against a variety of autoimmune diseases.
|
12848983 |
2002 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
Genetic factors including MHC ( IDDM 1-genetic locus) and non-MHC genes (IDDM 2 - IDDM X) have been shown to determine susceptibility to autoimmunity in type 1 diabetes or lifelong tolerance.
|
15372359 |
2004 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
In mice, CD4(+)CD25(+) regulatory T cells play a pivotal role in preventing autoimmunity.
|
15457445 |
2004 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
However, the biologic pathways responsible for DQ8-associated autoimmunity have yet to be defined, including possible defects in the CD4+CD25+ T regulatory cell compartment.
|
15556682 |
2004 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
Naturally occurring CD4+CD25+ regulatory T cells mediate immune suppression to limit immunopathogenesis associated with chronic inflammation, persistent infections and autoimmune diseases.
|
15743491 |
2005 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
CD4(+)CD25(+) Tregs are important in the maintenance of immunological self tolerance and in the prevention of autoimmune diseases.
|
15864353 |
2005 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
CD4+CD25+ regulatory T (Tr) cells are critical in regulating the immune response and thereby play an important role in the defense against infection and control of autoimmune diseases.
|
15972593 |
2005 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
Neonatal autoimmune disease: influence of CD4+ CD25+ regulatory T cells.
|
16036376 |
2005 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
Autologous stem cell transplantation for autoimmunity induces immunologic self-tolerance by reprogramming autoreactive T cells and restoring the CD4+CD25+ immune regulatory network.
|
16263787 |
2006 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
Taken together, our data suggest a novel mechanism by which iDCs delay autoimmunity through the CD4(+) CD25(+) Treg pathway and suggest IL-7 as a survival factor for these putative Tregs, which express the alpha-chain of its receptor at considerably higher levels than CD4(+) CD25(-) T-cells.
|
16380489 |
2006 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
CD4(+) CD25(+) regulatory T cells (Tregs) are critical in maintaining self-tolerance and preventing organ-specific autoimmunity.
|
16423064 |
2006 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
Deficient CD4(+)CD25(-) T cell spontaneous apoptosis may contribute to the development of autoimmunity.
|
16547287 |
2006 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
Accumulating evidence indicates an immunosuppressive role for CD4(+)CD25(+) regulatory T cells (Tregs) in autoimmune diseases.
|
16583400 |
2006 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
In the mouse model of FOXP3 deficiency, the lack of CD4+ CD25+ Tregs is responsible for lethal autoimmunity, indicating that FOXP3 is required for the differentiation of this Treg subset.
|
16741580 |
2006 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
CD4+CD25+ regulatory T cells help prevent autoimmune disease; a deficiency of these cells causes increased immunologic reactivity and autoimmunity.
|
16781310 |
2006 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
CD4(+)CD25(+) regulatory T lymphocytes (Treg) have been initially shown to prevent organ-specific autoimmunity.
|
17309822 |
2007 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
Taken together, our results indicate that the overexpression of hBcl-2 in CD4(+) T cells alters the homeostatic mechanisms controlling the number of CD4(+)CD25(+) T(regs) resulting in the inhibition of autoimmune diseases.
|
17312121 |
2007 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
CONCLUSIONS Association with GD, as well as that previously reported with T1D, suggests that the CD25 region is acting as a general susceptibility locus for autoimmune disease, and is consistent with a major role for the IL-2-receptor pathway in the development and function of T cells in the control of autoimmunity.
|
17371467 |
2007 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
Decreased numbers of CD4(+)CD25(+) FOXP3(+) T cells (Tregs) are associated with impaired immune homeostasis and development of autoimmune diseases.
|
17463169 |
2007 |
|
Autoimmune Diseases
|
0.200 |
AlteredExpression
|
group |
BEFREE |
CD4(+)CD25(+) T regulatory cells (Tregs), a subset of CD4(+) T cells expressing high levels of CD25 and the transcription factor Foxp3, are critical in maintaining immunologic homeostasis and preventing autoimmunity by suppressing self-reactive T cells.
|
17997492 |
2007 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
CD4+CD25+ regulatory T (Treg) cells play a crucial role in maintaining self-tolerance and preventing autoimmune disease.
|
18037337 |
2008 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
CD4(+)CD25(+) regulatory T (Treg) cells play critical roles in maintaining peripheral tolerance and preventing autoimmunity, but the characteristics of Treg cells have not yet been defined in CU.
|
18440785 |
2008 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
CD4(+)CD25(+)FOXP3(+) T regulatory cells (T(regs)) prevent autoimmunity by restricting overexuberant immune responses, but the same subpopulation can incur detrimental effects on antitumor responses.
|
19020538 |
2009 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
Whether autoantigen-specific Treg could be converted from CD4(+)CD25(-) T cells in patients with autoimmune diseases has not been reported.
|
19056692 |
2009 |