|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
CVID patients with AI had a reduced proportion of Tregs (both CD4+CD25+CD127<sup>low</sup> and FoxP3+ cells) compared with healthy controls.
|
31103252 |
2020 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Different factors, such as genetic factors (CD25, STAT4), epigenetic factors (DNA methylation, histone modifications) and environmental factors (xenobiotics, drugs, hormones) trigger autoimmunity.
|
31059841 |
2019 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
These complications can affect the balance of risks and benefits of biologic agents, and 2018 saw the withdrawal from the market of daclizumab, an anti-CD25 monoclonal antibody, due to concerns about the development of severe, unpredictable autoimmunity.
|
30830572 |
2019 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
T regulatory cells (Treg) play an important role in the maintenance of immune cell homeostasis, as it has been reported that CD4+CD25+ T cells suppress the auto-reactive responses in autoimmune diseases such as systemic lupus erythematosus (SLE).
|
30154885 |
2018 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
Thus, IL-2/CD25 represents a distinct class of IL-2 FPs with the potential for clinical development for use in autoimmunity or other disorders of an overactive immune response.
|
30282751 |
2018 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
Cells with Treg-specific FOXP3 demethylation but low CD25 are prevalent in autoimmunity.
|
28747257 |
2017 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
CD4+CD25+ regulatory T cells (Tregs) are a subset of mature T cells which have an important role in maintaining immune homeostasis and preventing autoimmune diseases.
|
27687891 |
2017 |
|
Autoimmune Diseases
|
0.200 |
AlteredExpression
|
group |
BEFREE |
Additionally, high CD25 expression in activated circulating immune cells and Tregs is a factor that has already been exploited by IL2 immunotherapies for treatment of tumours and autoimmune disease.
|
28556984 |
2017 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
A large number of polymorphic alleles of the IL2RA locus are associated with the development of various autoimmune diseases.
|
27876533 |
2017 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
We identified several CRISPRa-responsive elements with chromatin features of stimulus-responsive enhancers, including an IL2RA enhancer that harbours an autoimmunity risk variant.
|
28854172 |
2017 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
PTPN22 and IL2RA polymorphisms have been found to be associated with several autoimmune diseases including T1D.
|
27288719 |
2016 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
The CTLA4 and IL2RA loci were more strongly associated with double autoimmunity than with either T1D or CeD alone.
|
26405070 |
2015 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
GWASCAT |
Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases.
|
26301688 |
2015 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
Recent research has demonstrated an increasing role of newly discovered cells such as Th17 (CD4+IL-17+) or T regulatory cells (CD4+CD25+(high)FoxP3+) in the induction of autoimmune disorders.
|
26000316 |
2015 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
Genetic variants in il2 and il2ra have been associated with autoimmune disease susceptibility in both genome-wide association studies (GWAS) in humans and in genetic linkage studies in experimental models of autoimmunity.
|
25725581 |
2015 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
The genetic heterogeneity found at the IL2RA locus could help explain patterns of concomitance with other autoimmune diseases.
|
26133380 |
2015 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Human IL2RA null mutation mediates immunodeficiency with lymphoproliferation and autoimmunity.
|
23416241 |
2013 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
CD4(+) CD25(+) FOXP3(+) regulatory T cells (Tregs) are critical T cell subsets for maintaining self-tolerance and regulation of immune response to antigens thus play a pivotal role in preventing autoimmunity.
|
23432692 |
2013 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
Defective development and function of CD4(+)CD25(high+)Foxp3(+) regulatory T cells (Tregs) contribute to the pathogenesis of psoriasis and other autoimmune diseases.
|
23418628 |
2013 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
Myasthenia gravis (MG) is an autoimmune disorder in which CD4(+)CD25(+) FOXP3(+)regulatory T cells (Tregs) are thought to play important roles in driving the ongoing autoimmune response.
|
23228687 |
2013 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
We aimed to investigate for the first time the potential influence of the IL2/IL21, IL2RA and IL2RB most associated polymorphisms with autoimmunity on the endogenous non-anterior uveitis genetic predisposition.
|
23676143 |
2013 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
Previously reported associations between CD25/IL2RA and autoimmune diseases including GD in Caucasians again imply that heterogeneity exists in different ethnic populations.
|
23170961 |
2013 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Polymorphisms in genes associated with Treg function, such as IL2RA, confer a higher risk of autoimmune disease.
|
22461703 |
2012 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
CD4⁺CD25⁺ regulatory T cells (Tregs) mediate immune suppression and prevent autoimmune disorders.
|
22331026 |
2012 |