|
Graves Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
The number of CD4+CD25+Foxp3+ T lymphocytes in the GD model was significantly increased in the HF group compared with the DMSO group (P < 0.05).
|
28440200 |
2017 |
|
Graves Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
After imputation analysis, 13 imputed SNPs in the IL2RA block were weakly associated with GD (P ≤ 0·05).
|
23170961 |
2013 |
|
Graves Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
Our goal was to identify differences in CD4(+)CD25(high) Treg function or number in patients with GD and HT, compared to healthy controls (HC).
|
23379353 |
2013 |
|
Graves Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
The objective of this study was to investigate the effects of DEX on the function of regulatory T (Treg) cells (CD4(+)CD25(+)T cells) in patients with GD.
|
22219499 |
2012 |
|
Graves Disease
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Seven newly identified loci for autoimmune thyroid disease.
|
22922229 |
2012 |
|
Graves Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In this study, we analyzed whether polymorphic markers rs2104286, rs41295061, and rs11594656 located at the IL2RA/CD25 locus confer susceptibility to GD and are related to increased concentrations of sIL-2Rα.
|
21815908 |
2011 |
|
Graves Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We genotyped the five SNPs (rs12760457, rs2797415, rs1310182, rs2476599, and rs3789604) of the PTPN22 and the two SNPs (rs706778 and rs3118470 in the IL2RA gene) in 456 Japanese patients with AITD (286 with GD, 170 with Hashimoto's thyroiditis) and 221 matched Japanese control subjects.
|
20615141 |
2010 |
|
Graves Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
IL2RA/CD25, the gene for interleukin-2 receptor alpha, is emerging as a general susceptibility gene for autoimmune diseases because of its role in the development and function of regulatory T cells and the association of single-nucleotide polymorphisms (SNPs) within this gene with type 1 diabetes mellitus (DM), Graves' disease, rheumatoid arthritis (RA), and multiple sclerosis (MS).
|
19116909 |
2009 |
|
Graves Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
Moreover, the use of tag single nucleotide polymorphisms (SNPs) has also been used to implicate the recently identified type 1 diabetes locus, CD25 as a susceptibility gene for GD.
|
18081880 |
2008 |
|
Graves Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
RESULTS The multilocus test provided statistical evidence of an association between GD and the CD25 region (P = 4.5 x 10(-4)), with the pattern of association of the 20 tag SNPs similar to that found in T1D.
|
17371467 |
2007 |
|
Graves Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
By using a single microsatellite marker at each locus, we screened the type 1 diabetes loci IDDM4, IDDM5, IDDM6, IDDM8, and IDDM10 and the fucosyltransferase-2 locus for linkage in sib pairs with GD.
|
10762555 |
2000 |