IL2RA, interleukin 2 receptor subunit alpha, 3559

N. diseases: 540; N. variants: 43
Disease: melanoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025202
Disease: melanoma
melanoma 		0.080 GeneticVariation disease BEFREE We also identified two genes significantly associated with melanoma metastasis to the regional lymph nodes (PIK3CG and IL2RA), and two genes significantly associated with sex (KDM5C and KDM6A). 29975213 2018
CUI: C0025202
Disease: melanoma
melanoma 		0.080 Biomarker disease BEFREE Intratumoral depletion of regulatory T cells using CD25-targeted photodynamic therapy in a mouse melanoma model induces antitumoral immune responses. 28537894 2017
CUI: C0025202
Disease: melanoma
melanoma 		0.080 Biomarker disease BEFREE It is an essential transcription factor in CD4(+)CD25(+)FoxP3 regulatory T cells, which are therapeutic targets in disseminated cutaneous melanoma. 21489891 2011
CUI: C0025202
Disease: melanoma
melanoma 		0.080 Biomarker disease BEFREE We studied the kinetics of retention of IC on the surface of human CD25(+)CD16(-) NK cell lines (NKL and RL12) and GD(2)(+) M21 melanoma after IC binding to the cells via IL-2R and GD(2), respectively. 21248148 2011
CUI: C0025202
Disease: melanoma
melanoma 		0.080 Biomarker disease BEFREE MHC class I-restricted human melanoma epitope MART-1(27-35) specific TCR-engineered CD4+CD25- T cells synthesize Th1 type cytokines and exhibit cytolytic effector function upon cognate stimulation. 20547105 2010
CUI: C0025202
Disease: melanoma
melanoma 		0.080 AlteredExpression disease BEFREE Here we show that human melanomas express inducible T-cell costimulator ligand (ICOS-L/B7H) that can provide costimulation through ICOS for the expansion of activated Tregs maintaining high Foxp3 and CD25 expression as well as a suppressive function. 21098714 2010
CUI: C0025202
Disease: melanoma
melanoma 		0.080 Biomarker disease BEFREE Here, we studied the impact of IL-2 administration on the frequency and function of human CD4+ CD25(hi) T cells in immune intact patients with melanoma or renal cancer. 16304057 2006
CUI: C0025202
Disease: melanoma
melanoma 		0.080 AlteredExpression disease BEFREE In this report, we have analysed five human melanoma cell lines expressing the IL2R for their ability to secrete IL2. 8099724 1993