IL2RA, interleukin 2 receptor subunit alpha, 3559

N. diseases: 540; N. variants: 43
Disease: Systemic Scleroderma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.030 Biomarker disease BEFREE The function of both CD4+CD25+ and CD8+ Treg from SSc patients was analyzed by proliferation suppression assay. 23200754 2013
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.030 Biomarker disease BEFREE The frequency of CD4(+)CD25(+)FoxP3(+) Treg cells was significantly elevated in patients with SSc (3.62±1.14 vs 1.97±0.75, p<0.001) with diminished immunosuppression capacity. 23776439 2013
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.030 GeneticVariation disease BEFREE The associations of rs11594656 and rs12722495 were lost after conditioning to rs2104286, and allelic combination tests did not evidence a combined effect, indicating that rs2104286 best described the association between IL2RA and ACA presence in SSc. 22012429 2012