IL2RA, interleukin 2 receptor subunit alpha, 3559

N. diseases: 540; N. variants: 43
Disease: HIV-1 infection ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2363741
Disease: HIV-1 infection
HIV-1 infection 		0.070 Biomarker disease BEFREE Increased sensitivity of CD4+ T-effector cells to CD4+CD25+ Treg suppression compensates for reduced Treg number in asymptomatic HIV-1 infection. 20174666 2010
CUI: C2363741
Disease: HIV-1 infection
HIV-1 infection 		0.070 Biomarker disease BEFREE Decreased immune activation in resistance to HIV-1 infection is associated with an elevated frequency of CD4(+)CD25(+)FOXP3(+) regulatory T cells. 19301980 2009
CUI: C2363741
Disease: HIV-1 infection
HIV-1 infection 		0.070 Biomarker disease BEFREE The highest SLP-1 h was measured in the CD4+CD4+CD45RO+ CD25- population (T reg depleted), suggesting a role of Tregs in controlling immune activation during HIV-1 infection. 19303058 2009
CUI: C2363741
Disease: HIV-1 infection
HIV-1 infection 		0.070 Biomarker disease BEFREE When CD4(+)CD25(+/hi) Treg cells are depleted with the IL-2-toxin fusion protein (denileukin diftitox), HIV-1 infection is significantly impaired. 18544681 2008
CUI: C2363741
Disease: HIV-1 infection
HIV-1 infection 		0.070 AlteredExpression disease BEFREE HIV-1 infection enhanced Foxp3 expression in activated CD4+CD25- T cells; which was also abrogated by blockade of endogenous TGF-beta. 17688698 2007
CUI: C2363741
Disease: HIV-1 infection
HIV-1 infection 		0.070 Biomarker disease BEFREE Cross-clade recognition of p55 by cytotoxic T lymphocytes in HIV-1 infection. 9583596 1998
CUI: C2363741
Disease: HIV-1 infection
HIV-1 infection 		0.070 Biomarker disease BEFREE Therefore, p55 is the most useful antigen among the four Gag proteins for detection of the Gag antibodies and may even be one of the most useful antigens for the diagnosis of HIV-1 infection. 8569532 1995