Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Group III received a combined treatment of MSC and IL-4, while group IV served as a CIA diseased control group receiving phosphate buffer saline (PBS).
|
31382595 |
2019 |
Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This is the first report where quercetin was shown to modulate the immune response to arthritis via attenuation of the purinergic system (E-NTPDase and E-ADA activities) and the levels of IFN-gamma and IL-4.
|
31365139 |
2019 |
Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In addition, the capacity of IL4-10 FP to inhibit pro-inflammatory activity in ex-vivo and in-vivo arthritis models was investigated.
|
30307604 |
2019 |
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the collagen-induced model of arthritis, GCSF-F8 and F8-IL3 induced a worsening of the disease, while F8-IL4-F8 slowed arthritis progression but, surprisingly, exhibited substantial toxicity when used in combination with dexamethasone.
|
29438784 |
2018 |
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings indicate that pIL-18 gene combined with IL-4 ameliorates arthritis in the CIA mouse by suppression of Th1 and Th17 cytokines and increasing expression of FoxP3 and GATA-3.
|
29854762 |
2018 |
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The light microscopical evaluation of paws with arthritis revealed a predominant infiltration of neutrophils, which substantially decreased 24 h after treatment with F8-IL4 and DXM.
|
29365185 |
2018 |
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The arthritis-alleviative effects were closely associated with the augmentation of IL-4, IL-10, and collagen-specific IgG1, and with the distinct reduction of IFN-γ, collagen-specific IgG2a, and the marked decrease of proinflammatory cytokines IL-6, IL-17, and TNF-α and RANKL.
|
27393379 |
2016 |
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
DBA/1 mice doubly deficient in IL-4 and IL-10 were used to confirm that these two cytokines are important for the APL-induced attenuation of arthritis.
|
27837109 |
2016 |
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results suggest a detrimental role of IL-4 in GBS sepsis, whereas it plays a beneficial effect on GBS-induced arthritis.
|
19606256 |
2009 |
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Besides its responsiveness, the promoter strength proved sufficient for generating therapeutically efficacious levels interleukin-4, as demonstrated by the successful protection against cartilage erosion in collagen-induced arthritis.
|
17851546 |
2007 |
Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Protective effects were observed in CIA rats by injecting these recombinant DNA vaccines, which could alleviate arthritis index, decrease the levels of IFN-gamma and anti-CII antibody in serum, and increase the levels of IL-4.
|
18163955 |
2007 |
Arthritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in the interleukin-4 and IL-4 receptor genes modify risk for chronic inflammatory arthropathies in women.
|
16551465 |
2006 |
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Immunization of mice, lacking IL-4 and Stat6, with proteoglycan results in a significant increase in arthritis severity in comparison to wild-type controls, suggesting that arthritis severity is regulated by IL-4 through a Stat6-dependent mechanism.
|
12218156 |
2002 |
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, CII (256-276, N(263), D(266)) was incapable of preventing arthritis in DR1 IL-4(-/-) mice (genetically deficient in IL-4).
|
12483744 |
2002 |
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, the high concentration of PG-specific IgG2a isotype in IL-4-deficient mice corresponded to an increased severity of arthritis.
|
11879537 |
2002 |
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-4 adenoviral gene therapy reduces inflammation, proinflammatory cytokines, vascularization, and bony destruction in rat adjuvant-induced arthritis.
|
11145704 |
2001 |
Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here, we report that local overexpression of IL-4, introduced by a recombinant human type 5 adenovirus vector (Ad5E1mIL-4) prevents joint damage and bone erosion in the knees of mice with collagen arthritis (CIA).
|
10862785 |
2000 |
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
TNF-alpha and IL-1beta promote leukocyte recruitment to arthritic joints and may contribute to cartilage degradation while regulatory cytokines such as IL-4 and IL-1RA may in part determine the course of arthritis.
|
10921508 |
2000 |
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
To determine the efficacy of intra-articular IL-4 gene therapy in an animal model of arthritis using a retroviral vector, a retrovirus encoding rat IL-4 (DA-IL-4) was engineered, purified and concentrated to high titer (>/=109 CFU/ml).
|
10637442 |
1999 |
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
BALB/c mice immunized with proteoglycan generated a higher ratio of IFN-gamma to IL-4 that peaks at the onset of arthritis.
|
10553063 |
1999 |
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
New studies of streptococcal cell wall arthritis in rats demonstrated that beta 1 integrin-mediated cell-matrix interactions are involved in the induction and perpetuation of inflammatory synovitis and that systemic administration of interleukin-4 selectively suppresses established synovitis, presumably by effects on monocyte function.
|
7612411 |
1995 |