Hepatitis C
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This study provides evidence that increased IL-4 expression predicted advanced liver fibrosis in treatment of naive HCV-infected patients.
|
30946707 |
2019 |
Hepatitis C
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Interaction effects among IFN-γ+874, IL-2-330, IL-10-1082, IL-10-592 and IL-4-589 polymorphisms on the clinical progression of subjects infected with hepatitis B virus and/or hepatitis C virus: a retrospective nested case-control study.
|
28838891 |
2017 |
Hepatitis C
|
0.100 |
Biomarker
|
disease |
BEFREE |
More importantly, in BALB/c mice immunized intranasally twice at a 21-day interval with 10<sup>4</sup>, 10<sup>5</sup>, or 10<sup>6</sup> TCID<sub>50</sub> rgFLU-HCV<sub>CE1E2</sub>, the viral vector induced a robust antibody response to influenza and HCV and potent IFN-γ and IL-4 secretion in response to HCV antigens in a dose-dependent manner.
|
28778831 |
2017 |
Hepatitis C
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, the findings here demonstrate a positive association between HCV load of viremia and the mutant genotype IL-4-589/TT accompanied with low expression IL-4 in comparison with IL-6 expression.
|
28368861 |
2017 |
Hepatitis C
|
0.100 |
Biomarker
|
disease |
BEFREE |
Monocytes from healthy donor were cultured with DC growth factors such as IL-4 and GM-CSF either in the presence or absence of hepatitis C virus (HCV) viral proteins followed by LPS stimulation.
|
27298560 |
2016 |
Hepatitis C
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, no association was found between the -33T/C polymorphism and risk of liver diseases in all comparison models.This meta-analysis suggested that the IL-4 -590C > T polymorphism is associated with an increased risk of hepatitis C infection and hepatocellular carcinoma, especially among the Asian population.
|
26334904 |
2015 |
Hepatitis C
|
0.100 |
Biomarker
|
disease |
BEFREE |
HCV-specific CD4(+) and CD8(+) T-cell responses against six HCV peptides, situated within the non-structural (NS) proteins NS3, NS4b and NS5b, were measured by flow cytometry-through intracellular detection of gamma interferon (IFN-γ) or interleukin 4 (IL-4) and CD69 expression- in 27 sustained virological responders (SVR): 13 with and 14 without occult HCV infection in PBMCs, detected by strand-specific real-time PCR.
|
24127783 |
2014 |
Hepatitis C
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
On the other hand, serum IL-4 levels were higher in occult HCV infection than in CHC and control groups (p less than 0.001).
|
24674682 |
2014 |
Hepatitis C
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We investigated the association between hepatitis C virus (HCV) genotypes and host cytokine gene polymorphisms and serum cytokine levels in patients with chronic hepatitis C. Serum IL-6, TNF-α, IL-2, IFN-γ, IL-4, IL-10, and IL-17A levels were measured in 67 HCV patients (68.2% genotype 1 [G1]) and 47 healthy controls.
|
25193024 |
2014 |
Hepatitis C
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Patients with severe hepatitis C had higher levels of IL-4, IL-6, and IL-1β compared to milder cases.
|
25501184 |
2014 |
Hepatitis C
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The meta-analysis results indicated that the IL-4 -590T polymorphism might increase the risks of hepatitis B (HBV) and hepatitis C (HCV) infections.
|
23768103 |
2013 |
Hepatitis C
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that inheritance of the IL4 polymorphisms may be associated with resistance to combined antiviral therapy in Egyptian HCV patients.
|
22594992 |
2012 |
Hepatitis C
|
0.100 |
Biomarker
|
disease |
BEFREE |
In these patients we evaluated HCV-RNA in plasma and PBMCs, IFN-gamma and IL-4 before treatment, after 1, 3 and 12 months of treatment and 6 months after the end of treatment.
|
19968615 |
2010 |
Hepatitis C
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we analysed proliferation, IFN-gamma and IL-4 secretion (ELISpot) induced by the HCV antigens core, NS3, NS4, and NS5a in 21 anti-HCV-positive haemophiliac patients in relationship to their CCR5 genotypes (CCR5 wildtype n = 10, CCR5-Delta32 heterozygous n = 5 and CCR5-Delta32 homozygous n = 6).
|
19811439 |
2009 |
Hepatitis C
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we analysed proliferation, IFN-gamma and IL-4 secretion (ELISpot) induced by the HCV antigens core, NS3, NS4, and NS5a in 21 anti-HCV-positive haemophiliac patients in relationship to their CCR5 genotypes (CCR5 wildtype n = 10, CCR5-n32 heterozygous n = 5 and CCR5-n32 homozygous n = 6).
|
19172482 |
2009 |
Hepatitis C
|
0.100 |
Biomarker
|
disease |
BEFREE |
To explore a possible TH1 and TH2 cytokine dysregulation resulting in the inability to terminate hepatitis C virus (HCV) infection, we studied TH1 [interferon (IFN)-gamma, interleukin (IL)-2] and TH2 (IL-4, IL-10) mRNA expression of peripheral blood mononuclear cells (PBMC) in response to NS3 HCV antigen stimulation, in 31 untreated patients with chronic hepatitis C and 29 subjects with self-limited disease.
|
18184198 |
2008 |
Hepatitis C
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
IL-4 expression is elevated in severe recurrent HCV and may play a role in the progression of hepatic lesions after liver transplantation.
|
17460561 |
2007 |
Hepatitis C
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
IL-4 expression is elevated in severe recurrent HCV and may play a role in the progression of hepatic lesions after liver transplantation.
|
17460561 |
2007 |
Hepatitis C
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Levels of IL-4 and IL-4delta2 mRNA correlated in mitogen-stimulated PBMC from all patient groups but both were low in HIV/HCV genotype 1 patients.
|
16834574 |
2006 |
Hepatitis C
|
0.100 |
Biomarker
|
disease |
BEFREE |
Whereas subjects of group B showed IL-10-specific responses to HCV peptides more frequently than patients with self-limiting hepatitis C (p = 0.03), the number of IL-4-producing cells was not different between the two groups.
|
10604568 |
1999 |
Hepatitis C
|
0.100 |
Biomarker
|
disease |
BEFREE |
Lack of IL-2 induction was confirmed by a failure to amplify IL-2 mRNA upon NS3 antigen stimulation, whereas IL-4, IL-15, and gammaIfn mRNA were seen as early as 24 h. The predominance of IL-4 and IL-10 and the lack of IL-2 suggests that in vitro responses to at least some HCV antigens are biased towards a Th2 phenotype, which may be conducive to viral persistence.
|
10321955 |
1999 |