Leishmaniasis, Cutaneous
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
While no difference was observed regarding the number of interferon-gamma (IFN-γ)+ cells in lesions from pregnant compared to nonpregnant women with CL, interleukin-10 (IL-10) and IL-4 expression were approximately 3-times higher in lesions in pregnant women.
|
30165577 |
2019 |
Leishmaniasis, Cutaneous
|
0.390 |
Biomarker
|
disease |
BEFREE |
Th1 response (IFN-γ and IL-12p40) had higher expression levels compared to Th2 (IL-4) and IL-11 in CL patients.
|
30642262 |
2019 |
Leishmaniasis, Cutaneous
|
0.390 |
Biomarker
|
disease |
BEFREE |
Here, we investigated whether IL-4/IL-13 signaling via the common IL-4 receptor alpha chain (IL-4Rα) on keratinocytes contributes to susceptibility during experimental CL.
|
30275010 |
2018 |
Leishmaniasis, Cutaneous
|
0.390 |
Biomarker
|
disease |
BEFREE |
Together, these results demonstrate that IL-4-producing and IL-4Rα-responsive B cells are critical in regulating and assisting early T helper dichotomy toward Th2 responses, which are detrimental in cutaneous leishmaniasis but beneficial in acute schistosomiasis.
|
28916732 |
2017 |
Leishmaniasis, Cutaneous
|
0.390 |
Biomarker
|
disease |
BEFREE |
The gene expression of cytokines/chemokines in skin biopsies from the CL group showed higher transcript levels of modulatory (IL10 and TGFB1), anti-inflammatory (IL4), and pro-inflammatory (TNF, IFNG, IL12B, CCL2, CCL3, CCL5, CXCL10) biomarkers in recent lesions than in late lesions.
|
24084096 |
2014 |
Leishmaniasis, Cutaneous
|
0.390 |
Biomarker
|
disease |
BEFREE |
In this review, we summarize original and recent findings with regard to the role of IL-4 and IL-13 in cutaneous Leishmaniasis.
|
24412597 |
2014 |
Leishmaniasis, Cutaneous
|
0.390 |
Biomarker
|
disease |
CTD_human |
Evaluation of localized and systemic immune responses in cutaneous leishmaniasis caused by Leishmania tropica: interleukin-8, monocyte chemotactic protein-1 and nitric oxide are major regulatory factors.
|
20102417 |
2010 |
Leishmaniasis, Cutaneous
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
Upregulation of IL-4 was correlated with a higher parasite burden in early lesions of CL, which may be involved in the pathogenesis of CL by inhibiting a protective immune response.
|
19799628 |
2009 |
Leishmaniasis, Cutaneous
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our results suggest that functional genetic variants in the IL-4 promoter could influence the risk of developing CL while the polymorphism in the first intron of the IFN-gamma gene might influence the progression of disease towards CCL.
|
16950634 |
2006 |
Leishmaniasis, Cutaneous
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
The results clearly demonstrated a high level of IL-4 expression in nonhealing cases of CL and a low expression level of transcripts for IFN-gamma and IL-12.
|
11555409 |
2001 |