IL4, interleukin 4, 3565

N. diseases: 996; N. variants: 23
Disease: Leukemia, T-Cell ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023492
Disease: Leukemia, T-Cell
Leukemia, T-Cell 		0.050 AlteredExpression disease BEFREE In this study, we preliminarily investigated the mechanism of internalization of CCR9 on MOLT4 cell model (a human leukemia T-cell line, naturally expresses CCR9) and found that IL-2 upregulated the cell surface expression of IL-4Ralpha (CD124) greatly, whereas IL-4 had no significant influence on alpha (CD25) and beta subunits (CD122) of IL-2R. 19567201 2009
CUI: C0023492
Disease: Leukemia, T-Cell
Leukemia, T-Cell 		0.050 AlteredExpression disease BEFREE Here, we report that IL-2-dependent ATL cell lines also express IL-4Ralpha and respond to IL-4, which was verified by the activation of cytoplasmic transcriptional activator Stat6 protein. 12225394 2002
CUI: C0023492
Disease: Leukemia, T-Cell
Leukemia, T-Cell 		0.050 AlteredExpression disease BEFREE Furthermore, the high expression of IL-4R in ATL may be involved in the proliferation of leukemic cells and the leukemogenesis in this disease. 8641393 1996
CUI: C0023492
Disease: Leukemia, T-Cell
Leukemia, T-Cell 		0.050 Biomarker disease BEFREE IL-4 may play an important regulatory role in the production of IL-1 in ATL. 7628587 1995
CUI: C0023492
Disease: Leukemia, T-Cell
Leukemia, T-Cell 		0.050 AlteredExpression disease BEFREE These results indicate the activation of IL-4/IL-4 receptor system in leukemic cells from some ATL patients and suggest the possible involvement of the system in the proliferation of leukemic cells and the leukemogenesis in ATL. 3262383 1988