|
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
MS-associated biallelic combinations of haplogroup J with the alleles CCL5 rs2107538*A, PVT1 rs2114358*G, TNFSF14 rs1077667*C, and IL4 rs2243250*C, which were not associated with MS individually, were identified.
|
30713765 |
2020 |
|
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These DCs, which are with strong immunoregulatory characteristics and are functional in down-modulation of MS-like-disease displayed increased production of IL-4, IL-10 and TGF-β and low IL-12.
|
31108399 |
2019 |
|
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, IL4 and IL10 genes harbor important SNPs that may confer MS susceptibility.
|
31264107 |
2019 |
|
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Extracellular Vesicles Containing IL-4 Modulate Neuroinflammation in a Mouse Model of Multiple Sclerosis.
|
30017878 |
2018 |
|
Multiple Sclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Increased IL-1β and IFN-γ and decreased IL-12 and IL-4 levels were found in progressive MS compared with RRMS.
|
27023227 |
2017 |
|
Multiple Sclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
IL-10, TNF-α, IFN-γ, AOPP, and NOx levels were significantly higher and IL-4 lower in MS patients with a higher 2011 EDSS scores (≥3) as compared with those with EDSS < 3.
|
26732588 |
2017 |
|
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, LXA4-MS treatment increased macrophages and IL-4, suggesting a positive impact on wound healing.
|
28753648 |
2017 |
|
Multiple Sclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, no significant association was found between polymorphisms of IL4 I3(709)*VNTR, IL4R rs1801275 and MS susceptibility, respectively.
|
27000232 |
2016 |
|
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Sodium benzoate (NaB) deviates the cytokine profile to Th2 (or IL-4 producing) cells in EAE and thus might be effective in the treatment of MS.
|
27611715 |
2016 |
|
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We assessed the relationship of stimulated PBMC-produced IFN-γ, TNF-α, IL-4 and IL-10 in modulating relapse risk using a prospective cohort with established relapsing-remitting MS.
|
24790215 |
2015 |
|
Multiple Sclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The results of this study suggest that intron 3 VNTR polymorphism of the IL-4 gene was positively associated with predisposition to develop MS in Turkish population.
|
23756167 |
2013 |
|
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interestingly, increased IFN-gamma and IL-4 suggest that the control of EBV replication may be insufficient in MS patients.
|
20471696 |
2010 |
|
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have previously shown that short-term herpes simplex virus type 1-mediated IL4 gene therapy is able to inhibit experimental autoimmune encephalomyelitis (EAE), an animal model of MS, in mice and non-human primates.
|
18239607 |
2008 |
|
Multiple Sclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Clinical response to glatiramer acetate correlates with modulation of IFN-gamma and IL-4 expression in multiple sclerosis.
|
17613604 |
2007 |
|
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Additionally neither IL4 nor IL4R genes are susceptibility factors for Brazilian MS but may be able to modify ethnicity-dependent disease risk and penetrance of susceptibility factors.
|
17420820 |
2007 |
|
Multiple Sclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Sex specifically associated promoter polymorphism in multiple sclerosis affects interleukin 4 expression levels.
|
17855802 |
2007 |
|
Multiple Sclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
TNF-alpha, TNF-beta and IL-4 gene polymorphisms in Iranian patients with multiple sclerosis.
|
17295710 |
2007 |
|
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our data reinforce recent findings for a role of IL4-R in susceptibility to MS.
|
16313303 |
2005 |
|
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Protection from autoimmune encephalomyelitis and multiple sclerosis has been achieved with IL-4 therapy and IL-4 deficient mice developed a more severe form of clinical disease.
|
16169606 |
2005 |
|
Multiple Sclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A population-based study of IL4 polymorphisms in multiple sclerosis.
|
12667657 |
2003 |
|
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results suggest a possible importance of the TGF-beta2, IL-4R and IFN-gamma genes in MS.
|
9655468 |
1998 |
|
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-4 was more frequently observed among MS-derived clones.
|
9225681 |
1997 |
|
Multiple Sclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results show that the IL-4 B1 allele is associated with late onset of MS and therefore might represent a modifier of age of onset rather than a susceptibility factor for patients with MS.
|
9184650 |
1997 |
|
Multiple Sclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Thus, restricted populations of T cells capable of responding to TCGF/IL2/IL4, presumably reflecting in vivo activated cells, are compartmentalized in the nervous system in MS.
|
8892095 |
1996 |
|
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Surprisingly, these changes which favour a beneficial, disease-downregulating effect of IL-4 and TGF-beta in MS, were found to be confined to HLA-Dw2-positive patients.
|
9345450 |
1995 |