Nasal Polyps
|
0.100 |
Biomarker
|
disease |
BEFREE |
Dupilumab, a fully human monoclonal antibody that binds IL-4Rα and inhibits signaling of both IL-4 and IL-13, has shown efficacy across multiple diseases with underlying type 2 signatures and is approved for treatment of asthma, atopic dermatitis and chronic sinusitis with nasal polyposis.
|
31838750 |
2019 |
Nasal Polyps
|
0.100 |
Biomarker
|
disease |
BEFREE |
At this time, while there are no FDA-approved biologics for use in NP, research has highlighted the contributions of IL-4, IL-5, IL-13, and IgE as disease mediators in the pathogenesis of NP.
|
31073812 |
2019 |
Nasal Polyps
|
0.100 |
Biomarker
|
disease |
BEFREE |
The expression of chemokine (C-C motif) ligand 17 (CCL17) and IL-4 was significantly increased in IL-5<sup>+</sup> NPs, which was associated with eosinophil accumulation(p < 0.05).
|
28318118 |
2017 |
Nasal Polyps
|
0.100 |
Biomarker
|
disease |
BEFREE |
The expression levels of CD83, tumor necrosis factor-α (TNF-α), interleukin-4 (IL-4) and eosinophils (EOS) in NP tissues before and after glucocorticoid therapy and in control middle turbinate mucosa tissues were studied.
|
27117506 |
2017 |
Nasal Polyps
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The objective of this study was to determine differential expression of POSTN, IL-4, and IL-13 genes in the mucosa and polyps of 63 patients with CRSwNP and 23 chronic rhinosinusitis (CRS) without nasal polyps (CRSsNP) when compared with patients with nasal septum deviation (n=18) who were used as controls.
|
25674935 |
2015 |
Nasal Polyps
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The C-511T promoter polymorphism of the IL-1β gene and C-590T promoter polymorphism of the IL-4 gene were genotyped by polymerase chain reaction-restriction fragment length polymorphism analysis in 208 Polish patients with nasal polyps and 200 healthy Polish subjects.
|
24668571 |
2014 |
Nasal Polyps
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
TLR2, TLR4, TLR7, and IL-4 were significantly increased in CRSwNP patients when compared with either CRSsNP patients or control subjects, whereas TLR4 and TLR7, and downstream MyD88 were significantly decreased in CRSsNP patients versus patients from CRSwNP and control subjects.
|
23157229 |
2013 |
Nasal Polyps
|
0.100 |
Biomarker
|
disease |
BEFREE |
TNF-α(+) IL-4(+)CD4(+) T cells were detected in NP/AR nasal mucosa; TNF(+) IFN-γ(+) CD4(+) T cells were identified in NP/non-AR nasal mucosa.
|
20924287 |
2011 |
Nasal Polyps
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present data demonstrate that parasympathetic activity has the capacity to activate dendritic cells to release OX40 ligand, the latter induces CD4+ T cells to produce IL-4 and TNF-alpha that may further contribute to the pathogenesis of NP.
|
19951374 |
2010 |
Nasal Polyps
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, increased levels of IFN-gamma, IL-4 and IL-5 and decreased levels of IL-10 and TGF-beta were found in nasal polyps.
|
19639723 |
2009 |
Nasal Polyps
|
0.100 |
Biomarker
|
disease |
BEFREE |
We investigated whether nasal polyp fibroblasts produce TARC when stimulated with the breakdown products of microorganisms (TLR ligands) and a Th2 cytokine (IL-4).
|
18375080 |
2008 |
Nasal Polyps
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
T-590, which is dominant at position -590 of the IL-4 promoter, appears to be associated with a protective mechanism against nasal polyps in Korean populations.
|
17063753 |
2007 |
Nasal Polyps
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
TGF-beta and IL-4 may modulate the expression of CLC-2 and CLC-3 in CRSsNP.
|
17882904 |
2007 |
Nasal Polyps
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
T-590, which is dominant at position -590 of the IL-4 promoter, appears to be associated with a protective mechanism against nasal polyps in Korean populations.
|
17063753 |
2007 |
Nasal Polyps
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We suggested that the IL-4 promoter polymorphism -590 C/C is associated with the expression of 5-LO in the patients with nasal polyp.
|
17141086 |
2006 |
Nasal Polyps
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
We suggested that the IL-4 promoter polymorphism -590 C/C is associated with the expression of 5-LO in the patients with nasal polyp.
|
17141086 |
2006 |
Nasal Polyps
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest that a co-stimulus like LPS is necessary for IL-4 to make a strong induction of eotaxin in eosinophilic inflammations such as nasal polyposis.
|
15144475 |
2004 |
Nasal Polyps
|
0.100 |
Biomarker
|
disease |
BEFREE |
Characterization of interleukin-4-stimulated nasal polyp fibroblasts.
|
12920052 |
2004 |
Nasal Polyps
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
IL-4 and IL-4delta2 were differentially expressed in 4 nasal polyps.
|
10550742 |
1999 |