Schizophrenia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
While the immune profiles in the different schizophrenia phenotypes indicate the activation of the immune-inflammatory response system (IRS), there are simultaneous signs of CIRS activation, including increased levels of the IL-1 receptor antagonist (sIL-1RA), sIL-2R and tumor necrosis factor-α receptors, Th-2 and Treg phenotypes with increased IL-4 and IL-10 production, and increased levels of TRYCATs and haptoglobin, α2-macroglobulin, and other acute-phase reactants, which have immune-regulatory and anti-inflammatory effects.
|
31473906 |
2020 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
A few inflammation-related factors showed unique changes in specific disorders (e.g., IL-4 increased in BD, decreased in suicide, but had no change in MDD, ASD, PTSD and SCZ).
|
31534116 |
2019 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In general, we also found that in the adult offspring that were subjected to an animal model of SZ, FA had a protective effect in relation to the levels of IL-4, IL-6, and TNF-α, which indicates that the action of FA persisted in the adult offspring, since FA showed a lasting effect on the inflammatory response, which was similar in both the dams and their offspring.
|
28342013 |
2018 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The present study aimed to investigate the short and long-term effects of a concurrent exercise protocol on global histone H4 acetylation levels and inflammatory markers (interleukin-4 (IL-4), interleukin-6 (IL-6), interferon gamma (IFN-γ) and cortisol) in phytohemagglutinin-stimulated peripheral blood mononuclear cells (PBMC) and in peripheral blood of patients with schizophrenia (SZ), as well the intervention impact on anthropometric characteristics.
|
27810494 |
2017 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Correlations of Kynurenic Acid, 3-Hydroxykynurenine, sIL-2R, IFN-α, and IL-4 with Clinical Symptoms During Acute Relapse of Schizophrenia.
|
28275903 |
2017 |
Schizophrenia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Serum levels of interleukin-4 (IL-4), IL-6, IL-10, IL-17, interferon (IFN-γ), and (C-X-C motif) ligand 10/interferon gamma-induced protein 10 (CXCL10/IP10) were decreased, while levels of the chemokine (C-C motif) ligand 2/monocyte chemoattractant protein-1 (CCL2/MCP-1) were increased in the schizophrenia group in comparison with controls.
|
28011441 |
2017 |
Schizophrenia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The UHR subjects presented increased IL-4 levels compared with both the HC and CHRON patients.
|
29042899 |
2017 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Interleukin-4 gene (IL4) is considered as a potential candidate gene in schizophrenia association studies.
|
22528336 |
2012 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
PSYGENET |
The aim of the current case-control study was to examine whether the -590C/T (rs2243250) and -33C/T (rs2070874) IL4 gene polymorphisms are implicated in paranoid schizophrenia development in the Polish population.
|
22528336 |
2012 |
Schizophrenia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
A detailed fluorescence-activated cell sorting (FACS) analysis, e.g. of CD3+CD25+ T cells, IFN-γ+, IL-4+, IL-17A+ (CD4+) lymphocytes and CD4+CD25highFoxP3+ regulatory T cells, was performed on peripheral blood of 26 patients with recent-onset SCZ (in 19 of whom the inflammatory gene expression signature of the monocyte had been determined) and in age-/gender-matched healthy controls.Various relevant T-cell cytokines, e.g. sCD25, IFN-γ, IL-17A and IL-4, were measured in serum by a multiplex assay.
|
21255481 |
2011 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
PSYGENET |
A detailed fluorescence-activated cell sorting (FACS) analysis, e.g. of CD3+CD25+ T cells, IFN-γ+, IL-4+, IL-17A+ (CD4+) lymphocytes and CD4+CD25highFoxP3+ regulatory T cells, was performed on peripheral blood of 26 patients with recent-onset SCZ (in 19 of whom the inflammatory gene expression signature of the monocyte had been determined) and in age-/gender-matched healthy controls.Various relevant T-cell cytokines, e.g. sCD25, IFN-γ, IL-17A and IL-4, were measured in serum by a multiplex assay.
|
21255481 |
2011 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The present study suggests that IL2 and IL4 do not contribute to vulnerability to schizophrenia in the Japanese population.
|
18574615 |
2008 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
PSYGENET |
The present study suggests that IL2 and IL4 do not contribute to vulnerability to schizophrenia in the Japanese population.
|
18574615 |
2008 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
PSYGENET |
In this context, functional polymorphisms in the Interleukin-2 (IL-2) and Interleukin-4 (IL-4) genes appear to be principal candidates for genetic schizophrenia research.
|
16091861 |
2006 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
In this context, functional polymorphisms in the Interleukin-2 (IL-2) and Interleukin-4 (IL-4) genes appear to be principal candidates for genetic schizophrenia research.
|
16091861 |
2006 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A significant association of the IL-2 -330 TT genotype and of the IL-4 -590 CC genotype with schizophrenia could be identified.
|
16091861 |
2006 |
Schizophrenia
|
0.400 |
Biomarker
|
disease |
PSYGENET |
In conclusion, these results suggest that the polymorphisms in IL-4 promoter gene -590 and IL-4 Ralpha gene 1902 are not involved in the pathophysiology of schizophrenia in the Korean population.
|
12753568 |
2003 |
Schizophrenia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, these results suggest that the polymorphisms in IL-4 promoter gene -590 and IL-4 Ralpha gene 1902 are not involved in the pathophysiology of schizophrenia in the Korean population.
|
12753568 |
2003 |