|
Skin lesion
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In addition, IL-4 and IL-17A mRNA transcript levels were reduced in skin lesions after PAG treatment.
|
31794090 |
2020 |
|
Skin lesion
|
0.100 |
AlteredExpression
|
group |
BEFREE |
PSORI-CM02 also decreased pro-inflammatory IFNγ mRNA and IL-17 A mRNA, while increased IL-4 mRNA in mouse skin lesions.
|
30513504 |
2019 |
|
Skin lesion
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Degranulation and enzyme-linked immunosorbent assays were conducted to measure degranulation, proinflammatory cytokine levels, and prostaglandin E<sub>2</sub> concentrations in immunoglobulin E/antigen-sensitized RBL-2H3 mast cells.The therapeutic efficacy of <i>P. santalinus</i> extract in 2,4-dinitrochlorobenzene-induced atopic dermatitis was evaluated through morphological, physiological, and immunological analysis.<i>P. santalinus</i> extract inhibited <i>β</i>-hexosaminidase and histamine release and reduced tumor necrosis factor-<i>α</i>, interleukin-4, and prostaglandin E<sub>2</sub> secretion.Furthermore, <i>P. santalinus</i> extract suppressed atopic dermatitis-like skin lesions by regulating the serum levels of immunoglobulin E and immunoglobulin G2a, and messenger ribonucleic acid expression of T helper cell 1- and T helper cell 2-related mediators in the skin lesions.
|
30609435 |
2019 |
|
Skin lesion
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We also investigated the inhibitory capacity of WIKIM30 on the development of 2,4-dinitrochlorobenzene-induced atopic dermatitis (AD), a Th2-dominant allergic disease in mice.Oral administration of <i>L. sakei</i> WIKIM30 significantly reduced AD-like skin lesions and serum immunoglobulin E and IL-4 levels while decreasing the number of CD4<sup>+</sup> T cells and B cells and the levels of Th2 cytokines (IL-4, IL-5, and IL-13) in peripheral lymph nodes and enhancing Treg differentiation and IL-10 secretion in mesenteric lymph nodes.
|
30154801 |
2018 |
|
Skin lesion
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Here, by using a hydrogel patch as a transcutaneous delivery device for ovalbumin (an antigen) and Staphylococcus aureus δ-toxin (a mast cell activator), we efficiently induced acute atopic dermatitis-like skin lesions in BALB/c mice, a strain prone to Th2 responses, which were characterized by increased numbers of eosinophils, mast cells, and CCR4-expressing Th2 cells in the skin lesions; elevated levels of total and ovalbumin-specific IgE in the sera; and increased expression of IL-4, IL-17A, IL-22, CCL17, CCL22, and CCR4 in the skin lesions.
|
29510192 |
2018 |
|
Skin lesion
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These results demonstrated that SeMet supplementation suppresses AD-like skin lesions in BALB/c mice and inhibits the expression of total IgE and IL-4.
|
30175780 |
2018 |
|
Skin lesion
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Macroscopic and microscopic evaluation of skin lesions was performed together with measurements of serum levels of interleukin (IL)-1β, IL-6, tumour necrosis factor alpha (TNF-α), IL-17, IL-22, IL-10 and IL-4.
|
29409331 |
2018 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, DLE and GFSE synergistically showed a stronger ameliorative effect in skin lesions by reducing clinical scores; dermal infiltration of mast cells; ear and dorsal skin thickness; serum IgE and IL-4 production in atopic dermatitis-like mice.
|
28282783 |
2017 |
|
Skin lesion
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Furthermore, topical application of josamycin reduced the expression of IFN-γ and IL-4 in auricular lymph node cells and the skin lesions.
|
28459659 |
2017 |
|
Skin lesion
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Treatment with dTBP2 also decreased the serum levels of IgE and reduced IL-17A content in skin lesions and inhibited the expression of mRNAs of interleukin IL-4, IL-5, IL-6, IL-13, macrophage-derived chemokine (MDC), thymus and activation-regulated chemokine (TARC) and thymic stromal lymphopoietin (TSLP).
|
28134765 |
2017 |
|
Skin lesion
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We found that IL-33/ST2L were positively expressed in the skin lesions of AD patients and a high expression of IL-33 was induced in keratinocytes by IL-4 plus interferon [IFN]-γ or IFN-γ alone at the mRNA and protein levels.
|
27348082 |
2016 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
Oral administration of L. chungangensis CAU 28(T) suppressed the production of IL-4, IL-5, IL-12, IFN-γ, tumor necrosis factor-α, and thymus- and activation-regulated chemokine (TARC) in skin lesions, indicating that it strongly drives the local immune system with efficacy comparable to that of tacrolimus, a topical immunomodulatory drug used for the treatment of atopic dermatitis.
|
27289147 |
2016 |
|
Skin lesion
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In this study, we utilize PCR array technique to examine hundreds of inflammation-related genes in the IL-4 Tg mice before and after the onset of skin lesions as well as in their wild type (WT) littermates.
|
26585782 |
2016 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
In the skin lesions, IL-17(+) cells were more represented in psoriasis than in AD, while the number of IL-4-producing cells was reduced in psoriasis patients than in AD ones.
|
22699761 |
2012 |
|
Skin lesion
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Administration of CK onto DNCB-induced AD-like skin lesions in NC/Nga mice ameliorated lesion intensity scores, levels of IgE, thymus and activation-regulated chemokine (TARC), TNF-α, and IL-4 in serum and ears.
|
22407167 |
2012 |
|
Skin lesion
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Skin lesions begin to develop with increases in serum IgE levels and the expression of IL-4 mRNA in the lymph node and skin.
|
15591815 |
2005 |
|
Skin lesion
|
0.100 |
AlteredExpression
|
group |
BEFREE |
IL-4 mRNA expression was identified in only two of the eight very mild lesions, one of the ten subacute lesions, and none of the ten lichenified lesions, whereas IL-13 mRNA expression was identified in 27 of the 28 skin lesions of atopic dermatitis.
|
15014952 |
2004 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
PBMC and acute skin lesions of patients with atopic dermatitis (AD) are characterized by increased IL-4 and IL-13, but decreased IFN-gamma production.
|
11751999 |
2002 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
Recent studies of the cytokine pattern in skin lesions of patients with cutaneous T-cell lymphoma (CTCL) have shown that interleukin-4 (IL-4) and Il-10, both cytokines produced by T-helper type 2 cells, dominate in these lesions.
|
10664008 |
2000 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
In this study, we investigated the mRNA expression of the IL-4 receptor (IL-4Ralpha), IL-5Ralpha, GM-CSFRalpha, and IL-12Rbeta2 in biopsy specimens from acute and chronic AD lesions, uninvolved AD skin, normal skin, and psoriatic skin lesions.
|
9723668 |
1998 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
Immunohistochemical examination of the skin lesion showed increased numbers of mast cells and CD4+ T cells containing IL-4 necessary for IgE synthesis.
|
9088984 |
1997 |
|
Skin lesion
|
0.100 |
Biomarker
|
group |
BEFREE |
By reverse transcriptase-polymerase chain reaction, mRNAs for interleukin-4 (IL-4) and IL-10 were detected in the dermis of skin lesions in all cases (three cases of KiL and four cases of LyP).
|
8941669 |
1996 |
|
Skin lesion
|
0.100 |
AlteredExpression
|
group |
BEFREE |
However, as compared with acute AD skin lesions, chronic AD skin lesions had significantly fewer IL-4 mRNA-expressing cells (P < 0.01), but significantly greater IL-5 mRNA (P < 0.01).
|
8040343 |
1994 |