Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
IL-2 rs2069762 (recessive comparison), IL-4 rs2243250 (recessive and allele comparisons), IL-6 rs1800795 (dominant, recessive and allele comparisons), IL-8 rs4073 (dominant, recessive and allele comparisons), IL-10 rs1800871 (dominant, recessive and allele comparisons) and IL-10 rs1800896 (recessive comparison) polymorphisms were all significantly associated with TB in the total population.
|
31669382 |
2020 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
ML2044-stimulated IL-4 and CXCL8/IL-8 achieved the highest sensitivity (85.71% and 100%) and the highest specificity (95.24% and 84.21%) for discriminating PB patients from HHCs and TB patients, respectively.
|
31017900 |
2019 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The F/B ratio was positively related to the detectable IL-1B in TB (R<sup>2</sup> = 0.97, P < 0.01) and to the IL-4 in LTBI (R<sup>2</sup> = 0.27, P < 0.05).
|
30620398 |
2019 |
Tuberculosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Neutrophils can express cytokines that influence TB progression, and so we compared neutrophil and T-cell expression of the Th1 cytokines IFNγ and TNF, the Th2 cytokine IL-4, and regulatory cytokine IL-10 in M. tuberculosis-infected macaques to determine if neutrophil cytokine expression contributes to dysregulated immunity in TB.
|
31434990 |
2019 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
This is the first report of the evaluation of a potential whole-live combined vaccine against tuberculosis, which paradoxically seems to reduce production of pro-inflammatory cytokines while induces IL-4, leading us to further hypothesize that this combination might contribute as a therapeutic vaccine to reduce inflammation in severe TB cases.
|
30948175 |
2019 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this case-controlled study, we aimed to determine the role of single-nucleotide polymorphisms of interferon-gamma, interleukin-4 and interleukin-17 in susceptibility to tuberculosis.
|
29372577 |
2018 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Likewise, we show that DC-SIGN expression is accentuated in M(IL-4) macrophages derived from peripheral blood CD14<sup>+</sup> monocytes isolated from TB patients, or in macrophages stimulated with acellular TB-PE, arguing for the pertinence of DC-SIGN-expressing macrophages in TB.
|
29946317 |
2018 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Using a unique transcriptome technology (CAGE), we investigated the promoter-based transcriptional landscape of IFNγ (M1) or IL-4/IL-13 (M2) stimulated macrophages during Mtb infection in a time-kinetic manner.
|
29712924 |
2018 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL4 and TLR4 play significant roles in host immunity to tuberculosis.
|
29433383 |
2018 |
Tuberculosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In present study, we investigated the effect of rLipQ from Mycobacterium tuberculosis H37Rv on macrophage functions in vitro.Our results demonstrate that rLipQ significantly lowers the expression level of pro-inflammatory cytokines (TNF-α& IFN-γ) and augments the level of anti inflammatory cytokines such as IL-4 & IL-10as compared to LPS stimulated macrophages.
|
28412202 |
2017 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data show that in response to mycobacterial infection, IL-4 generated AAMs in chronic filarial infections have impaired immune responses to TB infection by increasing IL-10 production in a TPL-2 mediated manner.
|
28658262 |
2017 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, these results indicate a specific role for both p38 MAPK and IL-4 in ESAT-6-induced MCP-1 production by macrophages and suggest a pathway with significance in tuberculosis pathogenesis.
|
27154637 |
2016 |
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Multiple SNPs in IL4 and TOLLIP were associated with TB (P < 0.05).
|
25521228 |
2015 |
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that IL-2 (-330T/G), IL-4 (-589 C/T) and TGF-β1 (+869T/C) gene polymorphisms may be associated with TB susceptibility.
|
24313289 |
2014 |
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, rs2243268-A and rs2243274-G of the IL-4 gene were found to confer resistance to EPTB and severe TB in Chinese Han children.
|
24518693 |
2014 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-4 and IL-10 SNPs affect the ability of macrophages to counter infection with M. tuberculosis.
|
24624917 |
2014 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Expression of TNF-α, IFN-γ, TGF-β, and IL-4 in the spinal tuberculous focus and its impact on the disease.
|
25326857 |
2014 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Th1 cytokine interferon-gamma (IFN-γ) and Th2 cytokines interleukin 4 (IL-4) and interleukin 5 (IL-5) in 62 pulmonary tuberculosis (TB) patients (40 Warao indigenous patients [WP] and 22 Creole non-indigenous patients [CP]) and 24 healthy controls (12 Warao indigenous controls [WC] and 12 Creole non-indigenous controls [CC]) at 24 and 48 hours in response to purified protein derivative (PPD) from Mycobacterium tuberculosis.
|
20650294 |
2010 |
Tuberculosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our results demonstrated that strain M was a weaker gamma interferon (IFN-gamma) inducer than H37Rv for group N. Strain M induced the highest interleukin-4 expression in CD4+ and CD8+ T cells from MDR- and S-TB patients, along with the lowest cytotoxic T-lymphocyte (CTL) activity in patients and controls.
|
19720756 |
2009 |
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The findings support the hypothesis that elevated IL-4 production is generally associated with infection, but that TB disease is associated with a relatively increased expression of IL-4 compared to IFN-gamma and IL-4delta2.
|
18231607 |
2008 |
Tuberculosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Immunosuppression during active tuberculosis is characterized by decreased interferon- gamma production and CD25 expression with elevated forkhead box P3, transforming growth factor- beta , and interleukin-4 mRNA levels.
|
17299718 |
2007 |
Tuberculosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
From our observations, the IL-4 mRNA expression efficiency was attenuated in patients with pulmonary infection, either tuberculosis or pneumonia.
|
17961771 |
2007 |
Tuberculosis
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
From our observations, the IL-4 mRNA expression efficiency was attenuated in patients with pulmonary infection, either tuberculosis or pneumonia.
|
17961771 |
2007 |
Tuberculosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The differential stability of the Th2 agonist, IL-4, compared to the antagonist IL-4delta2, represents a hitherto undescribed post-transcriptional regulatory mechanism that may modulate the polarisation of Th1/Th2 responses in human TB.
|
17196882 |
2007 |
Tuberculosis
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Immunosuppression during active tuberculosis is characterized by decreased interferon- gamma production and CD25 expression with elevated forkhead box P3, transforming growth factor- beta , and interleukin-4 mRNA levels.
|
17299718 |
2007 |