|
Allergic asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In addition, IL-17A and IL-4 serum levels were found significantly elevated in patients with allergic asthma (p < 0.05).
|
31047104 |
2019 |
|
Allergic asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, we found that intranasal administration of miR‑410 effectively inhibited airway inflammation in OVA‑induced asthmatic mice by targeting IL‑4 and IL‑13 at the post‑transcriptional level. miR‑410 is thus a promising treatment for allergic asthma.
|
30535486 |
2019 |
|
Allergic asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
CD4+CD25+ Regulatory T Cells Decreased CD8+IL-4+Cells in a Mouse Model of Allergic Asthma.
|
31522445 |
2019 |
|
Allergic asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Amelioration of allergic asthma by Ziziphora clinopodioides via upregulation of aquaporins and downregulation of IL4 and IL5.
|
31015030 |
2019 |
|
Allergic asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore, epithelial-derived mediators, such as interleukin (IL)-25, IL-33, thymic stromal lymphopoietin (TSLP) and ezrin, may play a role as alarmins in IL-4/IL-13 signaling in allergic asthma (AA).
|
31486098 |
2019 |
|
Allergic asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The impact of the recombinantly produced IL-4 and IL-13 antagonist IL-4 mutein (IL-4M) on allergic sensitization and AIT outcome in experimental allergic asthma were analyzed in a murine model.
|
30829405 |
2019 |
|
Allergic asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Further investigation showed that IL4 (interleukin 4), a key effector Th2 cytokine in allergic asthma, was critical for autophagy induction in B cells both in vivo and in vitro, which further sustained B cell survival and enhanced antigen presentation by B cells.
|
29297752 |
2018 |
|
Allergic asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Increased IL-4- and IL-17-producing CD8<sup>+</sup> cells are related to decreased CD39<sup>+</sup>CD4<sup>+</sup>Foxp3<sup>+</sup> cells in allergic asthma.
|
28346024 |
2018 |
|
Allergic asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This finding suggests that clinical events concerning neonatal IL-4 over-exposure, including neonatal hepatitis B vaccination and allergic asthma in human infants, may have adverse implications for brain development and cognition.
|
29751176 |
2018 |
|
Allergic asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The SIT group, compared with the AA group, exhibited decreased sensitivity to the Der p allergen, concurrent with IL-4 down-modulation due to increased promoter DNA methylation, as estimated in PBMCs.
|
28603280 |
2018 |
|
Allergic asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Results showed that compared with healthy children, levels of IL-9, IL-4 and PU.1 were elevated and levels of IFN-γ were lower in children with allergic asthma.
|
28724400 |
2017 |
|
Allergic asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-4 signaling through the IL-4 receptor α (IL-4Rα) chain on CD4(+) T cells leads to TH2 cell differentiation in vitro, implying that IL-4Rα-responsive CD4(+) T cells are critical for the induction of allergic asthma.
|
26688514 |
2016 |
|
Allergic asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, maternal stress can alter fetal cytokine balance, favoring TH2 (allergic) immune responses characteristic of atopic asthma: interleukin 6 (IL-6), which has been associated with premature labor, can promote TH2 responses by stimulating production of IL-4 and IL-13.
|
26676148 |
2015 |
|
Allergic asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results demonstrate an anti-lymphangiogenic function of TH2 cells and their cytokines, suggesting a potential usefulness of IL-4 and/or IL-13 antagonist as therapeutic agents for allergic asthma through expanding LV mediated-enhanced antigen clearance from the inflammatory sites.
|
25648335 |
2015 |
|
Allergic asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of the present study was to investigate the possible association between IL-4 polymorphisms and allergic rhinitis and atopic asthma.
|
23654077 |
2013 |
|
Allergic asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Correlation between the ratio of T-bet/GATA-3 and the levels of IL-4 and IFN-γ in patients with allergic asthma.
|
21468546 |
2011 |
|
Allergic asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results support previous findings suggesting a role for CMA1 and IL-4 in atopic asthma and for IL-4 in atopy in general.
|
20736038 |
2010 |
|
Allergic asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In subgroup analysis, our results indicated a significant association and a recessive genetic mode of C-589T polymorphisms of IL-4 with atopic asthma.
|
18396027 |
2008 |
|
Allergic asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The frequency of IL-4+IFN-gamma-IL-10-CD4+ cells (Th2) was significantly higher in the group with mild atopic asthma than in that with mild non-atopic asthma.
|
17396024 |
2008 |
|
Allergic asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association between the polymorphisms of IL-4 gene promoter (-590C>T), IL-13 coding region (R130Q) and IL-16 gene promoter (-295T>C) and allergic asthma.
|
17303923 |
2007 |
|
Allergic asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The aim of this study was to determine whether patients with allergic asthma display overexpression of IL-4 and IL-13 genes.
|
17563406 |
2007 |
|
Allergic asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The role of Th2 cells (producing interleukin (IL-)4, IL-5 and IL-13) in allergic asthma is well-defined.
|
17083726 |
2006 |
|
Allergic asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The results showed that the IL-4 C-590T was not associated with allergic asthma in a Chinese population.
|
12940513 |
2003 |
|
Allergic asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Three patients were selected for an allergy-characteristic T cell phenotype with high IL-4 expression (AA) or IL-13 expression (AD).
|
12915770 |
2003 |
|
Allergic asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Haplotype analysis showed a strong association between the IL4-34T/-589T haplotype and asthma per se (P=0.041), and a strong association between the IL4RA I50/Q576 haplotype and atopic asthma (P=0.006).
|
12911786 |
2003 |