IL4, interleukin 4, 3565
N. diseases: 996; N. variants: 23
Source: ALL
| Disease | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year |
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0.100 | AlteredExpression | disease | BEFREE | In the experiment with RSV-induced BA exacerbation, Immunomax-treated mice were characterized by a significant decrease of the viral load in lung homogenates, an increased amount of M1 macrophages in the lung, a tendency toward Th2-dependent ovalbumin-specific IgG1 antibodies decrease in blood serum, a significant increase in RSV-activated CD4+ T cells secreting IFNγ (Th1 cells), and a simultaneous significant decrease in the amount of CD4<sup>+</sup> cells secreting IL-4 (Th2 cells) in the mouse spleen, which were detected by ELISPOT 1.5 months after experiment. | 30713767 | 2020 |
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0.100 | Biomarker | disease | BEFREE | Factors associated with disease severity were gestational age (odds ratio, 0.49; 95% confidence interval, 0.29-0.82; <i>P</i> = 0.007) and IL-4 (odds ratio, 9.67; 95% confidence interval, 2.45-38.15; <i>P</i> = 0.001).<b>Conclusions:</b> This study shows, for the first time, that elevated levels of ILC2s is associated with infant RSV severity. | 31237777 | 2019 |
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0.100 | Biomarker | disease | BEFREE | In contrast, reduced respiratory syncytial virus-induced IL-8 responses and increased 5'-cytosine-phosphate-guanine-3' (CpG)-induced IL-12p40 and allergen-induced IL-4 responses were associated with atopy. | 28089873 | 2017 |
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0.100 | AlteredExpression | disease | BEFREE | Using a neonatal mouse model, we have shown that down-regulation of IL-4 receptor α (IL-4Rα) with antisense oligonucleotides in the lung during neonatal infection protected from RSV immunopathophysiology. | 28389622 | 2017 |
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0.100 | Biomarker | disease | BEFREE | Intranasal administration of AS1411 (50 mg/kg) to RSV-infected mice and cotton rats was associated with partial reductions in lung viral titers, decreased virus-associated airway inflammation, and decreased IL-4/IFN-γ ratios when compared to untreated, infected animals. | 28925950 | 2017 |
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0.100 | AlteredExpression | disease | BEFREE | Formalin-inactivated RSV immune mice showed high levels of pulmonary inflammatory cytokines, macrophages, IL-4-producing T cells, and extensive histopathology. | 26656630 | 2016 |
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0.100 | GeneticVariation | disease | BEFREE | The frequencies of IL-4 -33 CC, CT and TT were 1.4%, 20.6% and 78%, respectively, in RSV bronchiolitis patients and 2.3%, 35.6% and 62%, respectively, in the controls. | 26289664 | 2016 |
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0.100 | GeneticVariation | disease | BEFREE | Each of the SNPs tested had previously been established to have a functional impact on immune responsiveness and two of the SNPs in the IL4 and IL4R genes had previously been associated with severe RSV bronchiolitis. | 24949794 | 2014 |
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0.100 | Biomarker | disease | BEFREE | Treatment with 131-2G significantly (P ≤ 0.001) decreased the percentage of interleukin-4 (IL-4)-positive CD4 and CD8 cells in RSV-stimulated spleen cells at all times p.i., while the percentage of interferon gamma (IFN-γ) T cells significantly (P ≤ 0.001) increased ≥ 75 days p.i. | 24990999 | 2014 |
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0.100 | Biomarker | disease | BEFREE | Combined anti-IL-4 and anti-RSV siRNAs were able to significantly reduce total cell counts and eosinophilia in bronchoalveolar lavage fluid, development of airway hyperresponsiveness, and airway inflammation and to downregulate IL-4 mRNA expression and RSV viral RNA, but to upregulate IFN-γ levels in lung tissues. | 24655063 | 2014 |
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0.100 | AlteredExpression | disease | BEFREE | During primary respiratory syncytial virus (RSV) infection, anti-Axl mAb treatment significantly increased the number of IFN-γ-producing T cells and NK cells and significantly suppressed RSV replication and whole lung levels of IL-4 and IL-13. | 24659691 | 2014 |
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0.100 | AlteredExpression | disease | BEFREE | Deletion of the NS1, but not NS2, protein resulted in three major effects: (i) an increased activation and proliferation of CD8+ T cells that express CD103, a tissue homing integrin that directs CD8+ T cells to mucosal epithelial cells of the respiratory tract and triggers cytolytic activity; (ii) an increased activation and proliferation of Th17 cells, which have recently been shown to have anti-viral effects and also indirectly attract neutrophils; and (iii) decreased activation of IL-4-producing CD4+ T cells--which are associated with enhanced RSV disease--and reduced proliferation of total CD4+ T cells. | 21533073 | 2011 |
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0.100 | AlteredExpression | disease | BEFREE | Respiratory Syncytial Virus elicited lower levels of interleukin 4, when compared with samples without virus identification. | 20685025 | 2011 |
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0.100 | AlteredExpression | disease | BEFREE | Lung inflammation, IFN-gamma:IL-4 mRNA expression ratios, airway obstruction (AO), and airway hyperreactivity (AHR) were significantly increased in mice inoculated with live RSV. | 18828742 | 2008 |
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0.100 | Biomarker | disease | BEFREE | We therefore tested recombinant RSV (rRSV) candidates expressing prototypic murine Th1 (gamma interferon [IFN-gamma]) or Th2 (interleukin-4 [IL-4]) cytokines, with detailed monitoring of responses to subsequent infections with RSV or (as a control) influenza A virus. | 17855518 | 2007 |
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0.100 | Biomarker | disease | BEFREE | Previously, we reported genetic associations between severe respiratory syncytial virus (RSV) bronchiolitis in infants and polymorphisms in the interleukin (IL)-4 and IL-4 receptor alpha (IL-4Ralpha) genes, providing evidence for involvement of T helper type 2 cytokines in the pathogenesis of RSV bronchiolitis. | 14722888 | 2004 |
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0.100 | GeneticVariation | disease | BEFREE | The IL-4 590T allele was found more frequently among children hospitalized with RSV than expected in the case-control (odds ratio [OR], 1.43; P=.04) and combination (OR, 1.41; P=.02) tests. | 12508140 | 2003 |
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0.100 | AlteredExpression | disease | BEFREE | We showed that both IL-4 and IL-13 activity must be inhibited to modulate G-specific responses resulting in severe RSV-induced disease. | 12574374 | 2003 |
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0.100 | AlteredExpression | disease | BEFREE | These results support the hypothesis that severe RSV disease might be related to increased Th2 response, which is perhaps mediated by overexpression of IL-4, and provide preliminary evidence for a genetic link between severe RSV disease and subsequent wheezing. | 12402189 | 2002 |
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0.100 | Biomarker | disease | BEFREE | Patients hospitalized because of RSV infection had increased numbers of CD16(+) and CD56(bright) cells and had RSV-specific increases in Th1 (interleukin [IL]-2 and interferon-gamma) and Th2 (IL-4 and IL-6) cytokines and CC chemokines (macrophage inflammatory protein [MIP]-1alpha, MIP-1beta, and RANTES [regulated on activation, normally T cell expressed and secreted]) mRNA expression. | 11992272 | 2002 |
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0.100 | Biomarker | disease | BEFREE | Flow cytometry of total pulmonary mononuclear cells isolated 10 days following infection with rRSV/mIL-2 revealed increased levels of CD4(+) T lymphocytes expressing either IFN-gamma or IL-4 compared to those of wt rRSV. | 10888656 | 2000 |
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0.100 | Biomarker | disease | BEFREE | Despite the increased IL-4 and IL-5 production and in contrast to mice primed with VV-G, mice primed with VV-Ftm(-) developed RSV-specific cytotoxic T lymphocytes (CTL) and maintained high levels of gamma interferon production. | 10559323 | 1999 |
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0.100 | Biomarker | disease | BEFREE | To determine this event, we studied production of IL-4 by human conjunctival epithelial cells, after infection with RSV. | 9663856 | 1998 |
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0.100 | AlteredExpression | disease | BEFREE | Lung eosinophilia was also associated with a localized reduction in IFN-gamma and increased IL-4 and IL-5 mRNA transcription as well as elevated RSV specific IgG1 antibody production. | 9680139 | 1998 |