Allergic rhinitis (disorder)
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression levels of interferon γ (IFN-γ), interleukin-17 (IL-17), and IL-4 were significantly decreased in the plasma of AR rats after injection of TCM-treated MSCs.
|
31535402 |
2020 |
Allergic rhinitis (disorder)
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Compared with the GFP-DC/AR group, mice in the Der p1-DC/AR group showed an ameliorated allergic response, a significant decrease in the levels of serum IgE, IgG1, and histamine, and a decrease in the expression of IL-4 and IL-13 mRNA and protein in the nasal mucosa.
|
30851701 |
2019 |
Allergic rhinitis (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
Collectively, the findings of this work suggest that there is a relationship between the OX40L expression level on B lymphocytes and allergic markers such as IgE and IL-4 in patients with allergic rhinitis.
|
30454861 |
2019 |
Allergic rhinitis (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
Compared with the CG‑associated groups (i.e., the CG and CCR3‑/‑CG groups), the levels of EPO, ECP, MBP, IL‑4, and IgE were significantly increased in the AR‑associated groups (that is, R and CCR3‑/‑AR).
|
30106146 |
2018 |
Allergic rhinitis (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although IL-33 did not induce the elevation of IL-4 production in the JCP-AR group, IL-33 substantially increased the production of IL-5 and IL-13 in comparison with antigen stimulation alone.
|
28857184 |
2018 |
Allergic rhinitis (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
We observed that in the AR-positive animals treated with BLG, the symptom scores were significantly higher (<i>P</i> < 0.01), the nasal mucosa edemas and inflammatory infiltrates were significantly alleviated (<i>P</i> < 0.01) and the serum IL-4 and SIgE levels were significantly decreased (<i>P</i> < 0.05) as compared with the control group.
|
29560095 |
2018 |
Allergic rhinitis (disorder)
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The frequencies of sneezing and scratching, as well as the levels of IgE, IL-4, and IL-13, in the serum were higher in the AR group than in the control group (p<0.01), whereas all these parameters were decreased significantly after HRS treatment (p<0.05).
|
28215576 |
2018 |
Allergic rhinitis (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present results strongly suggested that quercetin favorably modified the clinical condition of AR through the suppression of NO production from nasal epithelial cells after IL-4 stimulation.
|
30069224 |
2018 |
Allergic rhinitis (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
The loci in EMSY and IL4 can be considered as a hereditary marker for childhood AR.
|
30170133 |
2018 |
Allergic rhinitis (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
Allergen-specific IL-4 Tfh cells contribute to the production of allergen-specific IgE and correlate with clinical efficacy of AIT in allergic rhinitis patients, which suggest allergen-specific Tfh cells as a promising therapeutic target and biomarker for AIT in allergic rhinitis.
|
30124489 |
2018 |
Allergic rhinitis (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, the results showed that coptisine suppressed OVA-induced allergic rhinitis symptoms, such as nasal rubbing and OVA-specific IgE, and histamine, IL-4 and TNF-<i>α</i> levels in the serum of AR mice.
|
30469322 |
2018 |
Allergic rhinitis (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
The response was enhanced by IL-4 stimulation through TMEM16A, which might be related to fluid hypersecretion in allergic rhinitis.
|
28546154 |
2017 |
Allergic rhinitis (disorder)
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
After administration of EGCG, the number of sneezes and the occurrence of nasal rubbing were significantly decreased, the concentrations of immunoglobulin E (IgE) and histamine were suppressed in AR mouse serum, the levels of interleukin (IL)-1β, IL-4, and IL-6 were reduced in AR mice nasal lavage fluid (NLF), and the nasal mucosa mRNA and protein expression of cyclooxygenase 2 (COX-2), IL-1β, IL-4, and IL-6 were inhibited.
|
28558302 |
2017 |
Allergic rhinitis (disorder)
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, CYT387 treatment resulted in the reduction of IL-4 and IL-5 expression and increased IFN-γ level in AR mice, which was consistent with the levels of intracellular cytokine in Th2 cell.
|
28214951 |
2017 |
Allergic rhinitis (disorder)
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
DLC treatment (intravenous [i.v.]) significantly decreased the frequency of sneezing and nasal scratching and alleviated nasal inflammation by increasing the serum levels of IFN-γ and IL-12, while lowering the expression of IL-4.Thus, DLC (i.v.) treatment led to a marked elevation in T-helper 1/T-helper 2 (Th1/Th2) ratio when administered in the AR rats.
|
26155922 |
2015 |
Allergic rhinitis (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
HIF-1alpha inhibitors induce antiallergic effects by decreasing both local and systemic Th2 cytokine (IL-4 and IL-5) production, IgE production, and eosinophil infiltration into the nasal mucosa in an AR model.
|
24717944 |
2015 |
Allergic rhinitis (disorder)
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Levels of IL-4 and TGF-β1 were elevated in AR groups versus healthy controls (P < 0.05).
|
26708394 |
2015 |
Allergic rhinitis (disorder)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
SNPs in IL-4 are associated with AR and could change the clinical picture of the disease in patients.
|
24075353 |
2014 |
Allergic rhinitis (disorder)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of the present study was to investigate the possible association between IL-4 polymorphisms and allergic rhinitis and atopic asthma.
|
23654077 |
2013 |
Allergic rhinitis (disorder)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Epidemiological evidence on the relationship between IL4 single nucleotide polymorphisms (SNPs) and allergic rhinitis is limited.
|
22884982 |
2012 |
Allergic rhinitis (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
TNF-α(+) IL-4(+)CD4(+) T cells were detected in NP/AR nasal mucosa; TNF(+) IFN-γ(+) CD4(+) T cells were identified in NP/non-AR nasal mucosa.
|
20924287 |
2011 |
Allergic rhinitis (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
TSLP production is tightly correlated with IL-4 and severity of AR (P<0.05).
|
18720075 |
2009 |
Allergic rhinitis (disorder)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in the IL-13 and IL-4 receptor alpha genes and allergic rhinitis.
|
17091279 |
2007 |
Allergic rhinitis (disorder)
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In females only, the CTLA-4 (+49), but not the IL-4 promoter (-590), polymorphism was significantly associated with elevation of total IgE levels and allergic rhinitis.
|
14720259 |
2004 |
Allergic rhinitis (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results show that the IL-4 antisense PS-ODN effectively inhibits IL-4, IgE synthesis, and eotaxin, principal mediators of allergic inflammation, suggesting that PS-ODNs might offer a possible topical treatment for allergic rhinitis.
|
12642840 |
2003 |