Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The glucocorticoid-insensitive hyperrresponsiveness in isolated human airways induced by IL-13 and IL-4 provides further evidence that the IL-4Rα pathway should be targeted as a new strategy for treatment of airway hyperresponsiveness in asthma.
|
31805312 |
2020 |
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
These findings carry increasing relevance as IL-4Rα-targeted therapy is administered to human asthmatics.
|
31745261 |
2020 |
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Inducible deletion of IL-4Rα demonstrated therapeutic effects, on established allergic airway disease and prevented the development of ovalbumin-induced airway hyperreactivity, eosinophilia and goblet cell metaplasia in allergen-sensitised mice.
|
31782803 |
2019 |
Asthma
|
0.400 |
GeneticVariation
|
disease |
GWASCAT |
Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct.
|
30929738 |
2019 |
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We, therefore, devised a new strategy to increase the efficacy of the anti-IL-4Rα monoclonal antibody for the treatment of asthma and other atopic diseases by co-engaging CD32 and IL-4Rα on monocytic cells by choosing IgG classes or Fc mutations with higher affinities for CD32.
|
30950681 |
2019 |
Asthma
|
0.400 |
GeneticVariation
|
disease |
GWASCAT |
Shared genetics of asthma and mental health disorders: a large-scale genome-wide cross-trait analysis.
|
31619474 |
2019 |
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Dupilumab, a fully human monoclonal antibody targeting the interleukin-4 receptor α (IL-4Rα) subunit, demonstrated efficacy and acceptable safety in CRSwNP and other type 2 diseases (eg, atopic dermatitis and asthma).
|
30488542 |
2019 |
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Development of antagonistic antibody (Ab) against interleukin-4 receptor alpha (IL-4Rα) subunit of IL-4/IL-13 receptors is a promising therapeutic strategy for T helper 2 (T<sub>H</sub>2)-mediated allergic diseases such as asthma and atopic dermatitis.
|
31123339 |
2019 |
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We sought to target simultaneously the IL-4, IL-13, and IL-5 signaling pathways with a novel IL-4Rα/IL-5-bispecific antibody in a murine house dust mite (HDM) model of asthma.
|
29890236 |
2018 |
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To evaluate whether polymorphisms of IL4R (rs1805015), IL13 (rs20541), IL17A (rs2275913) and GSTP1 (rs1695) genes are associated with rhinitis and/or asthma in adults of Portuguese ancestry.
|
27561723 |
2018 |
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
It has a potential role in identifying asthmatics who may be responsive to treatment with monoclonal antibody therapy directed against Type 2 cytokines, such as interleukin (IL)-13, IL-4 receptor subunit-α and immunoglobulin E. The clinical utility of periostin measurements depends on better understanding of factors that may affect serum periostin levels, such as race.
|
30574168 |
2018 |
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Dupilumab (an anti-interleukin-4-receptor-α monoclonal antibody) blocks signalling of interleukin 4 and interleukin 13, type 2/Th2 cytokines implicated in numerous allergic diseases ranging from asthma to atopic dermatitis.
|
28478972 |
2017 |
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
IL4RA and ADAM33 variants may be risk markers of asthma exacerbations in type-2 inflammatory endotype.
|
28326636 |
2017 |
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We observed an association of rs1805011 polymorphism of IL4Rα gene with allergy (p=0.021), mild asthma (p=0.00005) and atopic dermatitis (p=0.0056).
|
26426602 |
2016 |
Asthma
|
0.400 |
GeneticVariation
|
disease |
GWASCAT |
Identification of a new locus at 16q12 associated with time to asthma onset.
|
27130862 |
2016 |
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Individuals with CT and GG genotype of C1112T in IL 13 and Ile50Val in IL 4 R were at twice the risk for the development of asthma compared to individuals with both non-risk genotypes.
|
25402004 |
2015 |
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, our studies led to identification of some key candidate genes, namely IRF2, IL6, IFNGR2, STAT4 and IL4RA that modulate genetic susceptibility to asthma in the Indian population.
|
25994869 |
2015 |
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms rs2243250 and rs2070874 of IL-4 and rs1801275 and rs1805011 of IL4R were associated with asthma.
|
23924473 |
2013 |
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The results indicated that LTA4H A-9188>G, TNFα G-308>A and IL-4Rα A1727>G polymorphisms were significantly associated with the development of difficult asthma in paediatric patients (p<0.001, p = 0.019 and p = 0.037, respectively).
|
23573270 |
2013 |
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our results support the important role of MS4A2, IL4R and ADAM33 genes in asthma and/or atopy susceptibility.
|
24039878 |
2013 |
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The results of this meta-analysis suggested that the IL4RA I50V and Q551R polymorphisms may be risk factors for developing asthma.
|
23922687 |
2013 |
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Nineteen IL4RA single nucleotide polymorphisms (SNPs) were tested in 407 non-Hispanic white subjects for association with the primary clinical end point of asthma exacerbations and changes in secondary end points for asthma symptom scores.
|
22541248 |
2012 |
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
A three-way gene-gene interaction was elucidated between the gene coding glutathione S-transferase P (GSTP1), the gene coding interleukin-4 receptor alpha chain (IL4Ra) and the gene coding insulin induced gene 2 (INSIG2) on the risk of lifetime asthma.
|
22355322 |
2012 |
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We found an association between atopic bronchial asthma and the SNPs Gln576Arg in IL4RA and -33C>T in IL4.
|
22533235 |
2012 |
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We investigated the interactive effects of 11 innate immunity-related genes (IL10, IL12b, IL8, TLR2, TLR4, CD14, IFNGR, CC16, IFNg, CMA1, and TGFB) and four IgE response genes (IL4, IL13, IL4RA, and STAT6) with 'Western' or 'Eastern' environments/lifestyles on asthma and allergy in Karelian children.
|
21749458 |
2011 |