|
Skin lesion
|
0.090 |
AlteredExpression
|
group |
BEFREE |
Immunofluorescence analysis of skin specimens from bullous pemphigoid and eczema revealed that infiltrating basophils in skin lesions widely expressed IL-5 and GM-CSF.
|
31783259 |
2020 |
|
Skin lesion
|
0.090 |
Biomarker
|
group |
BEFREE |
In addition, Th2-type cytokines, such as interleukin (IL)-4, IL-5 and IL-13, may be important in the development of skin lesions in fibrillar-type DH (especially in the infiltration of tissue by eosinophils), as in granular-type DH.
|
31106757 |
2019 |
|
Skin lesion
|
0.090 |
AlteredExpression
|
group |
BEFREE |
Also, it was demonstrated that MMB down-regulated the mRNA expression of IL-4, IL-5, IFN-γ and TSLP, and inhibited the phosphorylation of STAT1, STAT3 and STAT5 in skin lesions.
|
30544712 |
2018 |
|
Skin lesion
|
0.090 |
AlteredExpression
|
group |
BEFREE |
We also investigated the inhibitory capacity of WIKIM30 on the development of 2,4-dinitrochlorobenzene-induced atopic dermatitis (AD), a Th2-dominant allergic disease in mice.Oral administration of <i>L. sakei</i> WIKIM30 significantly reduced AD-like skin lesions and serum immunoglobulin E and IL-4 levels while decreasing the number of CD4<sup>+</sup> T cells and B cells and the levels of Th2 cytokines (IL-4, IL-5, and IL-13) in peripheral lymph nodes and enhancing Treg differentiation and IL-10 secretion in mesenteric lymph nodes.
|
30154801 |
2018 |
|
Skin lesion
|
0.090 |
AlteredExpression
|
group |
BEFREE |
Early tick-bite skin lesions (<24 hours of tick attachment) were characterized by a predominance of macrophages and dendritic cells, elevated mRNA levels of macrophage chemoattractants (CCL2, CCL3, CCL4) and neutrophil chemoattractants (CXCL1, CXCL8), of the pro-inflammatory cytokine, IL-1β, and the anti-inflammatory cytokine, IL-5.
|
27623398 |
2017 |
|
Skin lesion
|
0.090 |
AlteredExpression
|
group |
BEFREE |
Oral administration of L. chungangensis CAU 28(T) suppressed the production of IL-4, IL-5, IL-12, IFN-γ, tumor necrosis factor-α, and thymus- and activation-regulated chemokine (TARC) in skin lesions, indicating that it strongly drives the local immune system with efficacy comparable to that of tacrolimus, a topical immunomodulatory drug used for the treatment of atopic dermatitis.
|
27289147 |
2016 |
|
Skin lesion
|
0.090 |
AlteredExpression
|
group |
BEFREE |
IL-5 and IL-5R are highly expressed in the AD skin lesions, yet the reported levels of IL-8 are controversial.
|
17620072 |
2007 |
|
Skin lesion
|
0.090 |
AlteredExpression
|
group |
BEFREE |
Clonal T cells and CTCL skin lesions typically express Th2 cytokines, including interleukin (IL)-4, IL-5, and IL-10, but fail to produce Th1 cytokines.
|
16428475 |
2006 |
|
Skin lesion
|
0.090 |
AlteredExpression
|
group |
BEFREE |
As compared with normal control skin or uninvolved skin of patients with AD, acute and chronic skin lesions had significantly greater numbers of cells that were positive for mRNA, IL-4 (P < 0.01), and IL-5 (P < 0.01), but not for IFN-gamma mRNA expressing cells.
|
8040343 |
1994 |