|
Allergic asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In those patients, higher levels of IL-5, IL-6 and IL-17 were quantified in CD4<sup>+</sup> T-cell cultures as compared with patients with mild and moderate AA.
|
31173888 |
2019 |
|
Allergic asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The highest IL-5 serum concentration was in the SNEA group; it significantly differed compared with AA and HS.
|
31438916 |
2019 |
|
Allergic asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
A Comprehensive Evaluation of Nasal and Bronchial Cytokines and Chemokines Following Experimental Rhinovirus Infection in Allergic Asthma: Increased Interferons (IFN-γ and IFN-λ) and Type 2 Inflammation (IL-5 and IL-13).
|
28373098 |
2017 |
|
Allergic asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Allergic asthma is a T helper 2 cell (Th2)-mediated disease, in which Th2 cytokines interleukin (IL)-4, IL-5, and IL-13 are closely associated with the symptoms.
|
26965110 |
2016 |
|
Allergic asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-12 (p40) and IL-5 were the best predictor for extrinsic asthma in children with an increased odds ratio of 2.85 and 1.96 per log pg/ml increase (IL-12 (p40): 1.2-6.8, p=0.019, and IL-5: 1.2-2.5, p=0.025).
|
21179211 |
2010 |
|
Allergic asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These observations demonstrate that antisense oligonucleotid against IL-5 delivered by adeno-associated virus system is possibly an efficacious therapeutic strategy for allergic asthma and other eosinophil-related disorders.
|
19548628 |
2009 |
|
Allergic asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The role of Th2 cells (producing interleukin (IL-)4, IL-5 and IL-13) in allergic asthma is well-defined.
|
17083726 |
2006 |
|
Allergic asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest that IL-5 and TBXA2R genes may be disease-modifying genes in Korean children with atopic asthma.
|
15805995 |
2005 |
|
Allergic asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Hematopoietic cytokines such as interleukin (IL)-3, IL-5, and granulocyte macrophage colony-stimulating factor (GM-CSF) play a fundamental role in eosinophil functions in allergic asthma.
|
16237950 |
2005 |
|
Allergic asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The inhibitory effect on airway eosinophilia and AHR was associated with reduced levels of IL-4, IL-5, and IL-13 in the bronchoalveolar lavage fluid as well as reduced serum levels of OVA-IGE: These observations demonstrate the therapeutic potential of IL-4 mutant protein receptor antagonists that inhibit both IL-4 and IL-13 in the treatment of allergic asthma.
|
11313423 |
2001 |
|
Allergic asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A characteristic feature of allergic asthma is the overexpression of the T helper type 2 (Th2) cytokines interleukin-4 (IL-4), IL-5 and IL-13 by T lymphocytes.
|
10651947 |
2000 |
|
Allergic asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These findings support a causal association between augmented GATA-3 expression and dysregulated IL-5 expression in atopic asthma.
|
9949310 |
1999 |
|
Allergic asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
IFNgamma is secreted by TH1 cells while IL-4 and IL-5 are secreted by TH2 cells and an imbalance in the TH1/TH2 response may be responsible for atopic asthma.
|
9433936 |
1997 |
|
Allergic asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Peripheral blood mononuclear cells from atopic asthma patients both proliferated and produced IL-5 after incubation with mite allergen, suggesting that mite-specific helper T cells were involved in the eosinophilic inflammation of atopic asthma.
|
9440546 |
1997 |
|
Allergic asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Thus, we provide further evidence that CD3+ T cells are the most abundant cells expressing IL-4 and IL-5 mRNA in BAL and BX from allergic asthma.
|
7742012 |
1995 |
|
Allergic asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results indicate that CD3+ cells are the principal cellular source of IL-4 and IL-5 transcripts in atopic asthma and allergic rhinitis.
|
7613132 |
1995 |