Allergic rhinitis (disorder)
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
And no association of lncRNA ANRIL expression with IL-1β, IL-5, or IL-8 expression was discovered.LncRNA ANRIL expression correlates with increased AR risk, severity, and inflammation, implying that lncRNA ANRIL might be involved in the pathogenesis of AR.
|
31096432 |
2019 |
Allergic rhinitis (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
Tumour necrosis factor alpha and interleukin-5 inhibit olfactory regeneration via apoptosis of olfactory sphere cells in mice models of allergic rhinitis.
|
30980570 |
2019 |
Allergic rhinitis (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
PGD<sub>2</sub> -CRTH2 and cysLTs-CysLT1 axes may activate tissue-resident ILC2s to produce Th2 cytokines, IL-5 and IL-13, leading to the development of allergic inflammation in AR.
|
31267527 |
2019 |
Allergic rhinitis (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings show that CD4<sup>+</sup> T cells induce productions of IL-5 and IL-13 through MHCII on ILC2s in AR mice models.
|
30554982 |
2019 |
Allergic rhinitis (disorder)
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Serum IL-5 levels were negatively correlated with the expression of FasL in AR CD4<sup>+</sup> T cells.
|
30694585 |
2019 |
Allergic rhinitis (disorder)
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, CYT387 treatment resulted in the reduction of IL-4 and IL-5 expression and increased IFN-γ level in AR mice, which was consistent with the levels of intracellular cytokine in Th2 cell.
|
28214951 |
2017 |
Allergic rhinitis (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
The disruption of epithelial integrity by IL-4, IL-5, and TNF-alpha in vitro indicated a possible role for these cytokines in the pathogenesis of patients with allergic rhinitis.
|
27216347 |
2016 |
Allergic rhinitis (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
HIF-1alpha inhibitors induce antiallergic effects by decreasing both local and systemic Th2 cytokine (IL-4 and IL-5) production, IgE production, and eosinophil infiltration into the nasal mucosa in an AR model.
|
24717944 |
2015 |
Allergic rhinitis (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
To evaluate the clinical efficacy of sublingual immunotherapy (SLIT) with house-dust mite (HDM) extract and to examine the change of biomarkers (TIM-1, IL-5 and IL-10) after 6-month SLIT in children with allergic rhinitis (AR).
|
23800473 |
2013 |
Allergic rhinitis (disorder)
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
IL-5 levels were higher in induced sputum from patients with asthma and AR compared with nonatopic subjects (p = 0.020 and p = 0.032, respectively), but IFN-gamma levels showed no significant difference between the groups.
|
22186238 |
2012 |
Allergic rhinitis (disorder)
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In the FK group and DEX group, allergic symptoms, serum OVA-specific IgE, tissue eosinophil counts, IL-5 in NALF, and GATA-3 mRNAs expression decreased (p < 0.05), and IL-10 in NALF and Foxp3 mRNAs expression increased compared with the AR group (p < 0.05).
|
22487280 |
2012 |
Allergic rhinitis (disorder)
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In the murine model with AR, the IL-5 and IgE levels closely related to the allergic inflammation were significantly reduced after the intranasal administration of IL-5 AS-ODN/WSC complexes.
|
17459468 |
2007 |
Allergic rhinitis (disorder)
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This study was undertaken to analyse the allergen-induced in vitro mRNA expression of IL-4, IL-5, IL-10, TGF-beta and interferon (IFN)-gamma during SLIT in peripheral blood mononuclear cells (PBMC) of children with allergic rhinitis (AR).
|
16942566 |
2006 |
Allergic rhinitis (disorder)
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These data show that changes in IL-5 mRNA in patients with allergic rhinitis undergoing an allergen challenge correlate with total symptom scores better than changes in IL-5 protein eluted from filter paper.
|
12215387 |
2002 |
Allergic rhinitis (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although interleukin (IL)-4 and IL-5 have been demonstrated to play a critical role in the pathophysiology of allergic diseases such as allergic rhinitis, the mechanism that causes the predominance of Th2 lymphocytes has yet to be clarified.
|
11737045 |
2001 |
Allergic rhinitis (disorder)
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Nasal allergen provocation in patients with allergic rhinitis leads to expression of the proeosinophilic cytokines IL-5 and GM-CSF and tissue eosinophilia.
|
9802369 |
1998 |
Allergic rhinitis (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
When the levels of expression of cytokines and beta-actin mRNA were quantitated, the mean density ratios (cytokine/beta-actin) for IL-4 and IL-5 were higher in patients with allergic rhinitis than in control subjects.
|
9078933 |
1997 |
Allergic rhinitis (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results indicate that CD3+ cells are the principal cellular source of IL-4 and IL-5 transcripts in atopic asthma and allergic rhinitis.
|
7613132 |
1995 |
Allergic rhinitis (disorder)
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have investigated the phenotype of interleukin-5 (IL-5) mRNA+ cells in the nasal mucosa of subjects with allergic rhinitis.
|
8398174 |
1993 |