|
Osteosarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The IL-6 -174 G/C genotype was associated with risk for development and metastasis of osteosarcoma in Chinese Han population.
|
26810186 |
2016 |
|
Osteosarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
IL-6 174G/C polymorphism was obviously associated with OS risk in Asians, while TNF-α 238G/A polymorphism seemed to be associated with the decreased susceptibility to OS in Caucasians as Altman and Bland test indicated.
|
29228633 |
2017 |
|
Osteosarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To determine the molecular basis of this effect, we analyzed the human IL-6 promoter fused (-1,179 to +9) with the chloramphenicol acetyltransferase (CAT) reporter gene in stable transfections into human osteoblast-like osteosarcoma SaOS-2 cells.
|
9328832 |
1997 |
|
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The aim of the present study was to further determine the effect of IL-6/STAT3 signaling on the progression of osteosarcoma.
|
22743617 |
2012 |
|
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we employ Raman spectroscopy to the identification and discrimination of osteosarcoma cells from osteo-differentiated mesenchymal stromal cells (MSCs) by detecting the presence of HA and IL-6.
|
30523881 |
2018 |
|
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Both osteosarcoma cell lines have retained major functions of normal osteoblasts; principally, the capacity to produce hematopoietic growth factors (including IL-6) and osteocalcin, a noncollagenic protein essential in the bone formation process.
|
7579410 |
1995 |
|
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Human mesenchymal stem cells promote growth of osteosarcoma: involvement of interleukin-6 in the interaction between human mesenchymal stem cells and Saos-2.
|
20874851 |
2010 |
|
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Previously, we demonstrated that tumour self-seeding by CTCs occurs in osteosarcoma and revealed that interleukin-6 (IL-6) may promote CTC attraction.
|
26623559 |
2016 |
|
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore, we tested the hypothesis that TNF-alpha-induced IL-6 production in MG-63 osteosarcoma cells occurs via the p38 mitogen-activated protein kinase (MAPK) pathway.
|
11820362 |
2002 |
|
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
It suggested that targeted inhibition of HDAC2/NF-κB/IL-6 might be a potential approach for OS therapy.
|
30706385 |
2019 |
|
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The overexpression of miR-421 induced cell proliferation, invasion, and migration, and the release of pro-inflammatory IL-6 in cultured human osteosarcoma cells.
|
31718519 |
2020 |
|
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results identify IL-6 and CXCL8 as primary mediators of OS lung tropism and suggest pleiotropic, redundant mechanisms by which they might effect metastasis.
|
30135299 |
2018 |
|
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
TIMP3 Overexpression Improves the Sensitivity of Osteosarcoma to Cisplatin by Reducing IL-6 Production.
|
29731768 |
2018 |
|
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
SIAH1/ZEB1/IL-6 axis is involved in doxorubicin (Dox) resistance of osteosarcoma cells.
|
30265649 |
2019 |
|
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
ZOL increased the production of IL-6 in all cell types, whereas FOS only in osteosarcoma cell, which happened in dose dependent manner.
|
29454604 |
2018 |
|
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Finally, we isolated pure populations of EVs from serum and demonstrated that circulating levels of EV-associated TGFβ are increased in osteosarcoma patients.<b>Conclusions:</b> Collectively, our findings suggest that TEMSCs promote osteosarcoma progression and provide the basis for testing IL6- and TGFβ-blocking agents as new therapeutic options for osteosarcoma patients.<i></i>.
|
28053020 |
2017 |
|
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mice lacking IL-6 or NKT cells had accelerated development of IR-induced osteosarcomas.
|
24231354 |
2013 |
|
Osteosarcoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
In addition, irisin suppressed the IL-6-activated phosphorylation of STAT3 and the expression of Snail in osteosarcoma cells.
|
29048621 |
2017 |
|
Osteosarcoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
In vitro, depletion of SH3GL1 abrogates P130<sup>cas</sup> phosphorylation and IL-6- and VEGF-induced OS cell proliferation and migration.
|
28702842 |
2017 |
|
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our data showed that primarily IGF-1, TGF beta 1 and IL-6 (up to 25 ng/ml for 48 h) increased PTHrP mRNA expression and modified its perinuclear localization, while zoledronic acid (up to 100 microM for 48 h) inhibited cell proliferation and suppressed PTHrP expression in the MG-63 osteosarcoma cells.
|
16475708 |
2006 |
|
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Serum levels of IL-6 were determined in patients with osteosarcoma by ELISA and their relationship with pathological features and prognosis analyzed.
|
31777581 |
2019 |
|
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Competitive RT-PCR and Ala-pNA activity assays revealed that IL-6 and sIL-6R significantly increased the mRNA expression and activity of APN in both osteosarcoma cell lines.
|
11089884 |
1999 |
|
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Finally, H<sup>+</sup> -MSC conditioned medium differentially promoted OS stemness (sarcosphere number, stem-associated gene expression), and chemoresistance also via IL6 secretion.
|
27888521 |
2017 |
|
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
TET2 knockdown in OS cells suppressed upregulation of IL-6 and demethylation of its promoter in xenograft tumors and decreased tumor metastasis.
|
29515232 |
2018 |
|
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Using human MCF-7 breast carcinoma and G-292 osteosarcoma cell lines, it was investigated whether the phytoestrogens genistein and daidzein affect reporter gene transcription via the estrogen receptors (ERs) ERalpha and ERbeta1 as well as whether they affect the expression of estrogen-responsive genes in MCF-7 cells and the secretion of the cytokine IL-6 from G-292 cells.
|
17266178 |
2007 |