Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The overexpression of miR-421 induced cell proliferation, invasion, and migration, and the release of pro-inflammatory IL-6 in cultured human osteosarcoma cells.
|
31718519 |
2020 |
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Serum levels of IL-6 were determined in patients with osteosarcoma by ELISA and their relationship with pathological features and prognosis analyzed.
|
31777581 |
2019 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
It suggested that targeted inhibition of HDAC2/NF-κB/IL-6 might be a potential approach for OS therapy.
|
30706385 |
2019 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
SIAH1/ZEB1/IL-6 axis is involved in doxorubicin (Dox) resistance of osteosarcoma cells.
|
30265649 |
2019 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we employ Raman spectroscopy to the identification and discrimination of osteosarcoma cells from osteo-differentiated mesenchymal stromal cells (MSCs) by detecting the presence of HA and IL-6.
|
30523881 |
2018 |
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
TET2 knockdown in OS cells suppressed upregulation of IL-6 and demethylation of its promoter in xenograft tumors and decreased tumor metastasis.
|
29515232 |
2018 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results identify IL-6 and CXCL8 as primary mediators of OS lung tropism and suggest pleiotropic, redundant mechanisms by which they might effect metastasis.
|
30135299 |
2018 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
TIMP3 Overexpression Improves the Sensitivity of Osteosarcoma to Cisplatin by Reducing IL-6 Production.
|
29731768 |
2018 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
ZOL increased the production of IL-6 in all cell types, whereas FOS only in osteosarcoma cell, which happened in dose dependent manner.
|
29454604 |
2018 |
Osteosarcoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
In addition, irisin suppressed the IL-6-activated phosphorylation of STAT3 and the expression of Snail in osteosarcoma cells.
|
29048621 |
2017 |
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Finally, H<sup>+</sup> -MSC conditioned medium differentially promoted OS stemness (sarcosphere number, stem-associated gene expression), and chemoresistance also via IL6 secretion.
|
27888521 |
2017 |
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A positive correlation between the mRNA levels of IL-6 and SOX18 was observed in osteosarcoma tissues.
|
29184419 |
2017 |
Osteosarcoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
In vitro, depletion of SH3GL1 abrogates P130<sup>cas</sup> phosphorylation and IL-6- and VEGF-induced OS cell proliferation and migration.
|
28702842 |
2017 |
Osteosarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
IL-6 174G/C polymorphism was obviously associated with OS risk in Asians, while TNF-α 238G/A polymorphism seemed to be associated with the decreased susceptibility to OS in Caucasians as Altman and Bland test indicated.
|
29228633 |
2017 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Finally, we isolated pure populations of EVs from serum and demonstrated that circulating levels of EV-associated TGFβ are increased in osteosarcoma patients.<b>Conclusions:</b> Collectively, our findings suggest that TEMSCs promote osteosarcoma progression and provide the basis for testing IL6- and TGFβ-blocking agents as new therapeutic options for osteosarcoma patients.<i></i>.
|
28053020 |
2017 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Previously, we demonstrated that tumour self-seeding by CTCs occurs in osteosarcoma and revealed that interleukin-6 (IL-6) may promote CTC attraction.
|
26623559 |
2016 |
Osteosarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The IL-6 -174 G/C genotype was associated with risk for development and metastasis of osteosarcoma in Chinese Han population.
|
26810186 |
2016 |
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
It suggested that up regulation of IL-6 mediated visfatin induced in vitro motility of osteosarcoma cells.
|
27568842 |
2016 |
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We also elucidated that Interleukin 6 (IL-6) increases ADAMTS-2 and ADAMTS-3 mRNA and protein levels in different osteosarcoma cell lines namely, MG-63 and Saos-2.
|
24752352 |
2014 |
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Importantly, knockdown IL-6 reduced VEGF expression and abolished osteosarcoma conditional medium-mediated angiogenesis.
|
23219526 |
2013 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mice lacking IL-6 or NKT cells had accelerated development of IR-induced osteosarcomas.
|
24231354 |
2013 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The aim of the present study was to further determine the effect of IL-6/STAT3 signaling on the progression of osteosarcoma.
|
22743617 |
2012 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Human mesenchymal stem cells promote growth of osteosarcoma: involvement of interleukin-6 in the interaction between human mesenchymal stem cells and Saos-2.
|
20874851 |
2010 |
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Using human MCF-7 breast carcinoma and G-292 osteosarcoma cell lines, it was investigated whether the phytoestrogens genistein and daidzein affect reporter gene transcription via the estrogen receptors (ERs) ERalpha and ERbeta1 as well as whether they affect the expression of estrogen-responsive genes in MCF-7 cells and the secretion of the cytokine IL-6 from G-292 cells.
|
17266178 |
2007 |
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our data showed that primarily IGF-1, TGF beta 1 and IL-6 (up to 25 ng/ml for 48 h) increased PTHrP mRNA expression and modified its perinuclear localization, while zoledronic acid (up to 100 microM for 48 h) inhibited cell proliferation and suppressed PTHrP expression in the MG-63 osteosarcoma cells.
|
16475708 |
2006 |