|
Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In addition, agmatine restored total protein and albumin and reduces TNF-α and IL-6 levels in arthritis rats.
|
28006753 |
2017 |
|
Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Results from in vivo studies using a rat adjuvant-induced arthritis model showed specific inhibition of IL-6 levels in the serum and joints of EGCG-treated rats by 28% and 40%, respectively, with concomitant amelioration of rat adjuvant-induced arthritis.
|
18796608 |
2008 |
|
Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
As expected, CA at 10 and 20mg/kg significantly relieved the hind paw swelling and arthritis index, reduced the levels of IL-6 IL-1β, PGE2, TNF-α, MDA and increased SOD activity in serum.
|
26637957 |
2016 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Finally, the role of IL-6 and TGF-β<sub>1</sub> changes from immunosuppressive in resolving arthritis to stimulatory very early in the development of RA.
|
28847766 |
2017 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Histopathological assessment of joint sections demonstrated that HYPER-IL-6 increased arthritis severity and controlled intrasynovial mononuclear leukocyte recruitment through the CC-chemokine CCL2.
|
12960349 |
2003 |
|
Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
At 2 months post-surgery, intra-articular evidence of CTXII, IL1β, IL6, TNFα, and IFNγ was evaluated using a multiplex magnetic capture technique, and histological evidence of OA was assessed via a quantitative histological scoring technique.<b>Results</b>: Elevated levels of CTXII and IL6 were found in MCLT+MMT knees relative to skin-incision and contralateral controls; however, animal age did not affect the severity of joint inflammation.
|
31438735 |
2020 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
A novel anti-flt-1 hexapeptide, GNQWFI, abrogated the PlGF-induced increase in TNFalpha and IL-6 production, and also suppressed CII-induced arthritis and serum IL-6 concentrations in mice.
|
19180491 |
2009 |
|
Arthritis
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Complementary DNA from rheumatoid arthritis (RA) synovial fibroblasts treated with IL-6 and soluble IL-6 receptor (sIL-6R) was used to probe a cytokine microarray.
|
16802343 |
2006 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Foxp3(+)CD8(+) T cells that differentiated in vitro in the presence of IL-6 suppressed autoimmune colitis and arthritis in vivo.
|
20042455 |
2010 |
|
Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Peptidyl arginine deiminase inhibition suppresses arthritis via decreased protein citrullination in joints and serum with the downregulation of interleukin-6.
|
30285515 |
2019 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These features were most likely due to increased production of and enhanced responsiveness to G-CSF and IL-6 during arthritis in these mice.
|
16710471 |
2006 |
|
Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We now show that resistin displays potent proinflammatory properties by 1) strongly up-regulating IL-6 and TNF-alpha, 2) responding to TNF-alpha challenge, 3) enhancing its own activity by a positive feedback, and finally 4) inducing arthritis when injected into healthy mouse joints.
|
15843582 |
2005 |
|
Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, local blockades of these growth factors suppressed the development of cytokine-induced arthritis in mice by inhibiting chemokine and IL-6 expressions.
|
25556244 |
2015 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The results showed that terpenes have promising biological effects in relation to the treatment of arthritis, with the 24 terpenes identified in our survey being effective in the modulation of inflammatory mediators important to the physiopathology of arthritis, such as IL-6, IL-17, TNF-α, NFκB, and COX-2, among others.
|
30668316 |
2019 |
|
Arthritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Using human OA knee chondrocytes in vitro, we asked, does chloramphenicol (1) activate autophagy in chondrocytes; (2) protect chondrocytes from IL-1β-induced apoptosis; and (3) reduce the expression of matrix metallopeptidase (MMP)-13 and IL-6 (markers associated with articular cartilage degradation and joint inflammation).
|
31764352 |
2019 |
|
Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our results showed that FGF21 significantly alleviated the severity of arthritis by reducing cellular immune responses and exerted the similar anti-inflammatory effects with Adalimumab in decreasing the mRNA and protein expression levels of IL-2, IL-6 and IL-17.
|
28273637 |
2017 |
|
Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
STAT3 inhibition was also effective in treating an RA model, collagen-induced arthritis, in vivo through significant reduction in expression of IL-6 family cytokines and RANKL, inhibiting both inflammation and joint destruction.
|
21937456 |
2011 |
|
Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
CDD-450 also accelerated TNF-α and IL-6 mRNA decay, inhibited inflammation in mice with cryopyrinopathy, and was as efficacious as global p38α inhibitors in attenuating arthritis in rats and cytokine expression by cells from patients with cryopyrinopathy and rheumatoid arthritis.
|
29549113 |
2018 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These three cases suggest that anti-IL-6 receptor antibody may be an effective alternative to corticosteroids or TNFαi for the treatment of arthritis irAEs.
|
28830882 |
2017 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present study aims to clarify the influence of obesity on the action of IL-6 and to evaluate the efficacy of IL-6 signalling blockade in arthritis with obesity.
|
28421996 |
2018 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study examined the effect of the mouse anti-IL-6 receptor antibody, MR16-1, for the treatment of arthritis and enthesitis in McH-lpr/lpr-RA1 mice.
|
31200688 |
2019 |
|
Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These results suggest that TOV has significant anti-arthritic effects on collagen-induced arthritis in rats, which may be attributed to the inhibition of the levels of IL-1β, IL-6, IL-8, IL-17A, TNF-α, MMP-3 and MMP-9, and the increase of IL-10 in serum as well as down-regulation of the protein expression of COX-2 and iNOS in synovial tissues via suppressing the phosphorylation and degradation of IκB.
|
30831463 |
2019 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Addition of IL-17A, IL-17F and TNFα to synovial fibroblasts from patients with inflammatory arthritis resulted in significant production of IL-6 and IL-8, which was reduced to a larger extent by combined blockade of IL-17A and IL-17F than blockade of IL-17A alone.
|
31850514 |
2019 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The regulation of production of IL-6 by synoviocytes may be important in the pathogenesis of joint inflammation.
|
1550404 |
1992 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Additionally, anti-IL-6/anti-IL-21 treatment of CIA mice during the arthritis induction phase reduced disease development more potent than IL-6 or IL-21 inhibition alone, as effective as anti-TNF treatment.
|
28158305 |
2017 |