|
Arthritis
|
0.100 |
Biomarker
|
disease |
LHGDN |
Plasma IL-6 was the only biomarker related to treatment response and progressive erosive disease in patients with early RA, but it may not give additional information compared to CRP in relation to disease activity and treatment response.
|
18597410 |
2008 |
|
Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In a model of inflammatory arthritis, blockade of RAGE in mice immunized and challenged with bovine type II collagen suppressed clinical and histologic evidence of arthritis, in parallel with diminished levels of TNF-alpha, IL-6, and matrix metalloproteinases (MMP) 3, 9 and 13 in affected tissues.
|
12070776 |
2002 |
|
Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Dihydroartemisinin derivative DC32 attenuates collagen-induced arthritis in mice by restoring the Treg/Th17 balance and inhibiting synovitis through down-regulation of IL-6.
|
30336338 |
2018 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Treatment of CD11b<sup>-/-</sup> mice after establishment of the Treg/Th17 balance with an anti-IL-6 receptor mAb significantly suppressed the induction of Th17 cells and reduced arthritis severity.
|
28191643 |
2017 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The results indicate that SHW could be used to improving arthritis by reducing inflammatory factors (IL-6 and TNF-alpha).
|
30606189 |
2019 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The HTLV-1 tax gene may transactivate IL-6 gene in the synovial cells through NF-kappa B and may contribute in the pathophysiology of HTLV-I associated arthritis.
|
8596143 |
1995 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Deficiency of either IL-17 or IL-6 completely inhibits arthritis development, whereas interferon (IFN)-gamma deficiency exacerbates it.
|
17227914 |
2007 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-6: no change in healthy, metabolic disorders and arthritis, increased in cirrhosis and renal failure, decreased in PCOS + MS. IL-10: no change in healthy, IBD and metabolic disorders, increased in arthritis.
|
31060892 |
2020 |
|
Arthritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The -174G allele of the interleukin-6 gene confers susceptibility to systemic arthritis in children: a multicenter study using simplex and multiplex juvenile idiopathic arthritis families.
|
14613283 |
2003 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Systematic supplement of exogenous IL-6 reversed h-L. reuteri-induced CIA suppression.
|
31644891 |
2019 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We hypothesized that concomitantly administered anti-IL-6, anti-TNF-α and anti-IFN-γ antibodies would inhibit the development of arthritis in IL-17A-deficient mice.
|
28859307 |
2017 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interleukin 6 knock-out mice are resistant to antigen-induced experimental arthritis.
|
10623431 |
1999 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Upregulation of sphingosine-1-phosphate receptor 3 on fibroblast-like synoviocytes is associated with the development of collagen-induced arthritis via increased interleukin-6 production.
|
31173610 |
2019 |
|
Arthritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These preclinical findings may provide insight into why patients with arthritis being treated with IL-6 inhibitors develop new onset psoriasis and why IL-6 blockade for the treatment of psoriasis has not been clinically effective.
|
27984037 |
2017 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Vigna angularis inhibits IL-6-induced cellular signalling and ameliorates collagen-induced arthritis.
|
24097134 |
2014 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings demonstrate the ability of <i>L. helveticus</i> SBT2171 to downregulate the abundance of immune cells and the subsequent production of CII-specific antibodies and IL-6, thereby suppressing the CIA symptoms, indicating its potential for use in the prevention of RA.
|
28680422 |
2017 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Based on a number of adjuvant-induced experimental models, IL-6 is critical to the development of autoimmune diseases including experimental autoimmune encephalomyelitis, adjuvant-induced arthritis, and experimental autoimmune myocarditis.
|
19758168 |
2009 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The histopathological features, clinical score, paw swelling, as well as the production of pro-inflammatory cytokines including interleukin (IL)-1β, IL-6 and IL-17A were measured to determine the amelioration of butyrate on arthritis.
|
30660077 |
2019 |
|
Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Rats treated with UP1306 showed statistically significant improvements in arthritis severity markers, including uCTX-II (91.4% vs. collagen-induced arthritis (CIA)), serum IL-1β, TNF-α, and IL-6 levels as well as synovial MMP-13.
|
30691120 |
2019 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Loss of Foxo3 function resulted in more severe arthritis in vivo (both clinically and histologically) and was associated with higher titers of anticollagen antibodies and interleukin-6 in the blood.
|
27214848 |
2016 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
When inflammatory cytokines in synovial cells isolated from env-pX rats before they developed arthritis were examined, interleukin-6 (IL-6) was detected at a higher level than in synovial cells from WKAH rats, thus suggesting the critical role of IL-6 in env-pX arthritis.
|
15312124 |
2004 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
One patient with prolonged arthritis used canakinumab but arthritis showed progression and the treatment was changed to IL-6 inhibitor.
|
27328763 |
2017 |
|
Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Doxycycline and hAAT in combination also inhibited IL-6 expression from LPS-stimulated NIH/3T3 mouse fibroblast cells, indicating a contributing mechanism of arthritis inhibition.
|
19866480 |
2010 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Two loci on chromosome 15 control experimentally induced arthritis through the differential regulation of IL-6 and lymphocyte proliferation.
|
18606685 |
2008 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genetic variation in the gene for interleukin-6 (IL-6) contributes to the pathogenesis of inflammatory arthritis, but the role, if any, of epigenetic variability has not been reported.
|
18759290 |
2008 |