|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings demonstrate the ability of <i>L. helveticus</i> SBT2171 to downregulate the abundance of immune cells and the subsequent production of CII-specific antibodies and IL-6, thereby suppressing the CIA symptoms, indicating its potential for use in the prevention of RA.
|
28680422 |
2017 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
One patient with prolonged arthritis used canakinumab but arthritis showed progression and the treatment was changed to IL-6 inhibitor.
|
27328763 |
2017 |
|
Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
As expected, CA at 10 and 20mg/kg significantly relieved the hind paw swelling and arthritis index, reduced the levels of IL-6 IL-1β, PGE2, TNF-α, MDA and increased SOD activity in serum.
|
26637957 |
2016 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Loss of Foxo3 function resulted in more severe arthritis in vivo (both clinically and histologically) and was associated with higher titers of anticollagen antibodies and interleukin-6 in the blood.
|
27214848 |
2016 |
|
Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, local blockades of these growth factors suppressed the development of cytokine-induced arthritis in mice by inhibiting chemokine and IL-6 expressions.
|
25556244 |
2015 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Vigna angularis inhibits IL-6-induced cellular signalling and ameliorates collagen-induced arthritis.
|
24097134 |
2014 |
|
Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
STAT3 inhibition was also effective in treating an RA model, collagen-induced arthritis, in vivo through significant reduction in expression of IL-6 family cytokines and RANKL, inhibiting both inflammation and joint destruction.
|
21937456 |
2011 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Foxp3(+)CD8(+) T cells that differentiated in vitro in the presence of IL-6 suppressed autoimmune colitis and arthritis in vivo.
|
20042455 |
2010 |
|
Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Doxycycline and hAAT in combination also inhibited IL-6 expression from LPS-stimulated NIH/3T3 mouse fibroblast cells, indicating a contributing mechanism of arthritis inhibition.
|
19866480 |
2010 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
A novel anti-flt-1 hexapeptide, GNQWFI, abrogated the PlGF-induced increase in TNFalpha and IL-6 production, and also suppressed CII-induced arthritis and serum IL-6 concentrations in mice.
|
19180491 |
2009 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Based on a number of adjuvant-induced experimental models, IL-6 is critical to the development of autoimmune diseases including experimental autoimmune encephalomyelitis, adjuvant-induced arthritis, and experimental autoimmune myocarditis.
|
19758168 |
2009 |
|
Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Results from in vivo studies using a rat adjuvant-induced arthritis model showed specific inhibition of IL-6 levels in the serum and joints of EGCG-treated rats by 28% and 40%, respectively, with concomitant amelioration of rat adjuvant-induced arthritis.
|
18796608 |
2008 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
LHGDN |
Plasma IL-6 was the only biomarker related to treatment response and progressive erosive disease in patients with early RA, but it may not give additional information compared to CRP in relation to disease activity and treatment response.
|
18597410 |
2008 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Two loci on chromosome 15 control experimentally induced arthritis through the differential regulation of IL-6 and lymphocyte proliferation.
|
18606685 |
2008 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genetic variation in the gene for interleukin-6 (IL-6) contributes to the pathogenesis of inflammatory arthritis, but the role, if any, of epigenetic variability has not been reported.
|
18759290 |
2008 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Deficiency of either IL-17 or IL-6 completely inhibits arthritis development, whereas interferon (IFN)-gamma deficiency exacerbates it.
|
17227914 |
2007 |
|
Arthritis
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Complementary DNA from rheumatoid arthritis (RA) synovial fibroblasts treated with IL-6 and soluble IL-6 receptor (sIL-6R) was used to probe a cytokine microarray.
|
16802343 |
2006 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These features were most likely due to increased production of and enhanced responsiveness to G-CSF and IL-6 during arthritis in these mice.
|
16710471 |
2006 |
|
Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We now show that resistin displays potent proinflammatory properties by 1) strongly up-regulating IL-6 and TNF-alpha, 2) responding to TNF-alpha challenge, 3) enhancing its own activity by a positive feedback, and finally 4) inducing arthritis when injected into healthy mouse joints.
|
15843582 |
2005 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
When inflammatory cytokines in synovial cells isolated from env-pX rats before they developed arthritis were examined, interleukin-6 (IL-6) was detected at a higher level than in synovial cells from WKAH rats, thus suggesting the critical role of IL-6 in env-pX arthritis.
|
15312124 |
2004 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Histopathological assessment of joint sections demonstrated that HYPER-IL-6 increased arthritis severity and controlled intrasynovial mononuclear leukocyte recruitment through the CC-chemokine CCL2.
|
12960349 |
2003 |
|
Arthritis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The -174G allele of the interleukin-6 gene confers susceptibility to systemic arthritis in children: a multicenter study using simplex and multiplex juvenile idiopathic arthritis families.
|
14613283 |
2003 |
|
Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In a model of inflammatory arthritis, blockade of RAGE in mice immunized and challenged with bovine type II collagen suppressed clinical and histologic evidence of arthritis, in parallel with diminished levels of TNF-alpha, IL-6, and matrix metalloproteinases (MMP) 3, 9 and 13 in affected tissues.
|
12070776 |
2002 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interleukin 6 knock-out mice are resistant to antigen-induced experimental arthritis.
|
10623431 |
1999 |
|
Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The HTLV-1 tax gene may transactivate IL-6 gene in the synovial cells through NF-kappa B and may contribute in the pathophysiology of HTLV-I associated arthritis.
|
8596143 |
1995 |