|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Thus, our study identifies miR-146a as an important molecular brake that blocks the autocrine IL-6- and IL-21-induced Th17 differentiation pathways in autoreactive CD4 T cells, highlighting its potential as a therapeutic target for treating autoimmune diseases.
|
28872459 |
2017 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Thus IRF-1 may be at the nexus of the interplay between IFN-γ and IL-6 in exacerbating a xenobiotic-induced inflammatory response, regulation of interferon responsive genes and autoimmunity.
|
28453771 |
2017 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
MCs of diabetic NOD mice are overly inflammatory and secrete large amounts of IL-6 that favors differentiation of IL-17-secreting T cells at the site of autoimmunity.
|
26732858 |
2017 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Together, these findings identify a key mechanism whereby B cells drive autoimmunity via local IL-6 production required for T<sub>FH</sub> differentiation and autoimmune GC formation.
|
28899868 |
2017 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
In autoimmune diseases, toll-like receptor (TLR)-stimulated pro-inflammatory IL-6-secreting B cells exert pathogenic roles.
|
29104574 |
2017 |
|
Autoimmune Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The systemic autoimmunity type-SLE was observed seven months after the application of TMPD, in which the animals from the negative control group (animals with damage and without any other treatment) developed articular inflammation, proteinuria, an increment of the antinuclear antibody titters and tissue pro-inflammatory cytokines levels (IL-1β, IL-6, TNF-α e IFN-γ) as well as the anti-inflammatory cytokine IL-10.
|
28587079 |
2017 |
|
Autoimmune Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Monocytes produce high levels of inflammatory cytokines including IL-6 and TNF-α that are involved in autoimmunity, inflammatory diseases, cardiovascular disease and obesity.
|
27079270 |
2016 |
|
Autoimmune Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
We found that the Dicer1-regulated microRNA (miR)-183-96-182 cluster (miR-183C) was highly expressed in Th17 cells and was induced by cytokine IL-6-STAT3 signaling. miR-183C expression enhanced pathogenic cytokine production from Th17 cells during their development and promoted autoimmunity.
|
27332731 |
2016 |
|
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We present new findings that Lyp promotes TLR responses in primary human monocytes and that the autoimmunity risk Lyp620W variant is more effective at promoting TLR-induced interleukin-6 than the non-risk Lyp620R protein.
|
26683155 |
2016 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Interleukin-6 (IL-6) is a key pathogenic cytokine in multiple autoimmune diseases including rheumatoid arthritis and multiple sclerosis, suggesting that dysregulation of the IL-6 pathway may be a common feature of autoimmunity.
|
27629486 |
2016 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
To evaluate the association between development, progression, and response to therapy among patients with immune thrombocytopenia (ITP) and different cytokine gene polymorphisms known to be related to autoimmunity [tumor necrosis factor (TNF)-alpha, interleukin (IL)-10, IL-6, IL-17, IL-1Ra].
|
27007229 |
2016 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
The role of IL-6 in regulating progressive CNS autoimmunity was assessed by treating GFAPγR1Δ mice with anti-IL-6 neutralizing antibody during chronic EAE.
|
25896970 |
2015 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Kawasaki disease was associated with higher IL-17A and IL-6, a cytokine profile similar to other autoimmune diseases.
|
25585854 |
2015 |
|
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The rs1800795 gene polymorphism of IL-6 is associated with various autoimmune diseases, like multiple sclerosis.
|
26640809 |
2015 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Evidence of elevated levels of the proinflammatory cytokine IL-6 has been routinely observed during inflammatory responses and in a number of autoimmune diseases.
|
25794663 |
2015 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Interleukin-6 (IL-6) is a critical regulator of the immune system and has been widely implicated in autoimmune disease.
|
24670876 |
2015 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
In addition, we discuss the effect of targeting IL-6 in recent experimental and clinical studies on autoimmune diseases and transplant rejection.
|
24647663 |
2014 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
However, dysregulated continual synthesis of IL-6 is involved in the development of chronic inflammatory autoimmune diseases.
|
24594001 |
2014 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Tocilizumab, a recombinant humanized anti-IL-6 receptor antibody, has been shown to be effective in several autoimmune diseases, including uveitis.
|
24528300 |
2014 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Due to its major role in initiation as well as resolving inflammation, deregulation of IL-6 is a mainstay of chronic inflammatory and autoimmune diseases.
|
25031389 |
2014 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
It is characterized by accumulation of an excessive amount of extracellular matrix molecules that primarily include collagen type I. IL-6 is a profibrotic cytokine that is elevated in the prototypic fibrotic autoimmune condition systemic sclerosis and is known to induce collagen I expression, but the mechanism(s) behind this induction are currently unknown.
|
24550394 |
2014 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Systemic lupus erythematosus (SLE) is the prototype of human autoimmune disease in which various inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1, IL-6 and interferon (IFN) play crucial pathogenic roles.
|
23139385 |
2013 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Specifically, the cellular processes related to cell proliferation (for example, epidermal growth factor, platelet-derived growth factor, nuclear factor-κB, Wnt/β-catenin signaling, stress-activated protein kinase c-Jun NH2-terminal kinase), inflammatory response (for example, interleukins IL2 and IL6, the cytokine granulocyte-macrophage colony-stimulating factor and the B-cell receptor), general signaling cascades (for example, mitogen-activated protein kinase, extracellular signal-regulated kinase, p38 and TRK) and apoptosis are activated in most of the analyzed autoimmune diseases.
|
23190644 |
2013 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
IL-6 is thought to play an important role in autoimmune diseases and the effect of its receptor inhibitor-tocilizumab-has been recently studied.
|
24106699 |
2013 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Here, we combined two genome-wide mouse screens with SNP-based disease association studies, revealing 1,700 genes related to the IL-6 amplifier, 202 of which showed 492 indications of association with ailments beyond autoimmune diseases.We followed up on ErbB1 from our list.
|
23434511 |
2013 |