|
Atherosclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In apolipoprotein E-null mice, a model for atherosclerosis, levels of BMP-4, HSP70, MGP, and interleukin-6 were elevated in the aortic wall.
|
19661459 |
2009 |
|
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to explore the relation between abdominal fat distribution and some inflammatory risk factors of atheromatosis and IL-6 174G_C gene polymorphism in non-obese healthy subjects.
|
19569017 |
2009 |
|
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
IL6 -174 allele G homozygozity associates with beneficial profile of early predictors of atherosclerosis such as high CAC, HDL-C and apoA1 as well as low systolic and diastolic blood pressure in men.
|
18774574 |
2009 |
|
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to investigate whether IL6 -174 G>C is associated with the risk factors and early markers of atherosclerosis.
|
19592000 |
2009 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
CTD_human |
Our results suggested that pravastatin's aortic atherosclerosis preventing action via attenuation of IL-6 action may partially depend on modulation of STAT3 activity.
|
19330073 |
2008 |
|
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in the IL6 gene in Asian Indian families with premature coronary artery disease--the Indian Atherosclerosis Research Study.
|
18449426 |
2008 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Although the relationship between atherosclerosis and inflammatory cells has been recognized in recent years, the effect of interleukin-6 (IL-6) genetic variants associated with atherosclerosis is still controversial.
|
18281810 |
2008 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this review we discuss the possible impact on AT development of several genetic determinants involved in inflammation, oxidative stress and cytoprotection (IL-6, TNF-alpha, IL-10, CD14, TLR4, MT, HSP70).
|
18611449 |
2008 |
|
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Growing evidence suggests that polymorphisms at position -174 and -572 in interleukin-6 (IL-6) gene are associated with various manifestations of atherosclerosis.
|
18279814 |
2008 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Recent studies showed that interleukin 6 (IL-6) has a key role in the pathogenesis of atherosclerosis by binding 2 specific receptors, gp80 and gp130.
|
17472849 |
2007 |
|
Atherosclerosis
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
HIV protease inhibitors increase TNF-alpha and IL-6 expression in macrophages: involvement of the RNA-binding protein HuR.
|
17531241 |
2007 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
LHGDN |
In our work we presented the role of IL-6 in development and progression of atherosclerosis.
|
17684929 |
2007 |
|
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Although the IL-6 -174G/C promoter polymorphism has been associated with carotid artery atherosclerosis and coronary heart disease, its relation to ischemic stroke is unclear.
|
17916761 |
2007 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Membrane-type serine protease-1/matriptase induces interleukin-6 and -8 in endothelial cells by activation of protease-activated receptor-2: potential implications in atherosclerosis.
|
17255532 |
2007 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
LHGDN |
Augmented levels of CD44 in macrophages from atherosclerotic subjects: a possible IL-6-CD44 feedback loop?
|
16620830 |
2007 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Proinflammatory cytokines, like interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha), are implicated in the development of atherosclerosis.
|
17460178 |
2007 |
|
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The aim of our study was to evaluate the effect of the IL-6 -174 G/C polymorphism on hemostatic or inflammatory markers in patients with peripheral arterial occlusive disease (PAOD), a common manifestation of obliterative atherosclerosis.
|
18091699 |
2007 |
|
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To better clarify the role of CD14 in atherosclerosis, we typed CD14 C-260T polymorphism in old Italian (Central of Italy) atherosclerotic patients with carotid stenosis related to lipid assessment, inflammation (soluble CD14, IL-6 serum levels) and IL-6, TNF-alpha, IL-10, Metallothioneins (MT) gene expressions in carotid plaques.
|
17098305 |
2007 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our data underline the central role of IL-6 in low-grade inflammation contributing to atherosclerosis and CVD.
|
16900203 |
2006 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this paper, we reviewed data regarding to the pivotal role played by the zinc-gene interaction in affecting some relevant cytokines (IL-6 and TNF-alpha) and heat shock proteins (Hsp70-2) in ageing, successful ageing (nonagenarians) and in some age-related diseases (atherosclerosis and infections).
|
16513158 |
2006 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
It is unknown whether IL-6, a central regulator of inflammation, is a cause of or just a marker of atherosclerosis.
|
16467451 |
2006 |
|
Atherosclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Counteracting pro- and anti-inflammatory responses of serum cytokines have been reported, but the relevance of TNF-alpha, TGF-beta and IL-6 gene expression in peripheral blood leukocytes and their contribution to systemic inflammation in atherosclerosis, especially after acute myocardial infarction (AMI), has not been investigated yet.
|
16718633 |
2006 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Proinflammatory cytokines, such as interleukin-1beta (IL-1beta), IL-6, and tumor necrosis factor-alpha (TNF-alpha), are suggested to have an important role in the process of atherosclerosis.
|
16487030 |
2006 |
|
Atherosclerosis
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Thus, these two SNPs in the promoter region and intron 3 of the IL-6 gene might play a role in the blood pressure regulation and progression of atherosclerosis in the Japanese.
|
15969253 |
2005 |
|
Atherosclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Chronic inflammation due to high IL-6 production occurs in type 2 diabetes (NIDDM) and atherosclerosis.
|
16518702 |
2005 |