IL6, interleukin 6, 3569

N. diseases: 2367; N. variants: 22
Disease: Cholelithiasis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0008350
Disease: Cholelithiasis
Cholelithiasis 		0.030 AlteredExpression disease BEFREE Higher levels of IL-6, IL-10, IL-12 (p70), and IL-13 were associated with increased risk of gallstones (i.e. 29671891 2018
CUI: C0008350
Disease: Cholelithiasis
Cholelithiasis 		0.030 Biomarker disease BEFREE Although the pro-inflammatory cytokines such as TNF-α and IL-6 may promote gallstone formation, in this study no significant correlation between TNF-α and IL-6 polymorphisms and gallstone formation was seen. 24078093 2013
CUI: C0008350
Disease: Cholelithiasis
Cholelithiasis 		0.030 GeneticVariation disease BEFREE These results suggest that TNFA -308 (G/A) polymorphism may influence the susceptibility of female gender gallbladder cancer in absence of gallstones while IL6 -174 G/C polymorphism does not seem to be playing significant role in the susceptibility to gallbladder cancer. 18260730 2009