Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
LPS acute stimulation of VSMCs promoted a NO-dependent reduction in migration and contraction, while preconditioning with LPS promoted IL-6-dependent increases in migration and contraction, evidencing that VSMCs can present phenotype modifications that persist after sepsis, thereby contributing to postsepsis cardiovascular events.
|
31794773 |
2020 |
Septicemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Interleukin-6 levels significantly decreased after treatment in the early-onset sepsis group (p = 0.037).
|
31568052 |
2020 |
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Fifteen or 30 days after sepsis induction, Aβ content, TNF-α, IL-1β, and IL-6 and cognitive performance were determined.
|
31701437 |
2020 |
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Clinical and experimental studies have demonstrated the importance of IL-6 in sepsis; however, the role of TCZ has not been investigated.
|
31440860 |
2020 |
Septicemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The levels of IL-6, CK-MB, sST2 and IgE in the sepsis group were significantly higher than those of the sham group (P < 0.01).
|
30529771 |
2019 |
Septicemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Mice subjected to mild IH did not differ from normoxic controls, except a higher IL-6 level after sepsis induced.
|
31501504 |
2019 |
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Presepsin, procalcitonin, IL-8, and IL-6 showed a high diagnostic ability for sepsis at admission with area under the curve of 0.934, 0.798, 0.775, and 0.751, respectively.
|
31651475 |
2019 |
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Butorphanol can reduce the content of inflammatory factors TNF-α, IL-1, and IL-6 through the NF-κB signaling pathway, thereby relieving the brain injury caused by sepsis.
|
31389587 |
2019 |
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
We aimed to systematically assess the overall value of interleukin 6 (IL-6) in diagnosing neonates with sepsis.
|
30734480 |
2019 |
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Diagnostic accuracy of interleukin-6 for early-onset sepsis in preterm neonates.
|
30966828 |
2019 |
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The α7 nAChR partial agonist GTS-21 reduces secretion of pro-inflammatory cytokines including interleukin-6 (IL6) and tumor-necrosis factor (TNF) in models of endotoxemia and sepsis, and its anti-inflammatory effects are widely ascribed to α7 nAChR activation.
|
30947238 |
2019 |
Septicemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In the sepsis cohort CSF NT-proCNP levels correlated with CSF Interleukin-6 (IL-6) levels (r = 0.616, p < 0.05) and systemic inflammation represented by high plasma procalcitonin (PCT) levels at day 3 (r = 0.727, p < 0.05).
|
30423400 |
2019 |
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Receiver operating characteristic curve analysis of the SOFA score, PCT, NT-proBNP, IL-6, PT, and TT showed an area under the curve of 0.872, 0.732, 0.711, 0.706, 0.806, and 0.691, respectively, for diagnosing sepsis.
|
30477377 |
2019 |
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Macrophages play an important role in the early stage of sepsis as they are tasked with eliminating invading microbes and also attracting other immune cells by the release of proinflammatory cytokines such as interleukin-1β, interleukin-6, and tumor necrosis factor-α.
|
31658116 |
2019 |
Septicemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
DNA methylation profiles correlate with IL-10 and IL-6 levels, significantly increased in monocytes in sepsis, as well as with the Sequential Organ Failure Assessment score; the observed changes associate with TFs and pathways downstream to toll-like receptors and inflammatory cytokines.
|
31665078 |
2019 |
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
A number of pre-clinical studies have shown an auto amplification of pro-inflammatory cytokines such as tumor necrosis factor alpha (TNF-α), interleukin (IL)-1β, and IL-6 in the first few hours after sepsis induction, also increased blood-brain barrier permeability, elevated levels of matrix metalloproteinases, increased levels of damage-associated molecular patterns were demonstrated.
|
29687346 |
2019 |
Septicemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In myocardium, TNF and IL-6 were significantly elevated in sepsis, TNF in both ventricles and IL-6 mostly in RV, while IL-1β, IL-18 and C5a were significantly higher in RV compared to LV after PAB (all p<0.05).
|
31247004 |
2019 |
Septicemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Trial sequential analysis showed that a large sample size was needed to get a more reliable result of the association between IL-6-174 G/C polymorphism and sepsis in non-adults.
|
30782124 |
2019 |
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
After this, the electrodes were functionalised with an antibody for interleukin-6 (IL-6) which is a protein involved in the immune response to infection and whose levels in the blood increase during progression of sepsis.
|
30602262 |
2019 |
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The diagnostic and prognostic value of IL-6 was superior to those of PTX3 and PCT for sepsis and septic shock.
|
31718563 |
2019 |
Septicemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
SDC-1, Ang-2, sTM, VAP-1 and IL-6 levels were measured at ICU admission from 619 patients with sepsis.
|
31512003 |
2019 |
Septicemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Plasma levels of miR-187 in sepsis patients were inversely correlated with those of TNF-α and IL-6 (r = -0.2841, -0.2163), and plasma levels of miR-21 and miR-145 were positively correlated with those of TNF-α and IL-6 (r = 0.615, 0.3057, 0.4465, 0.2734).
|
31415369 |
2019 |
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Determining the accuracy of interleukin-6 (IL-6) concentrations in plasma, which is proposed as a new biomarker for the diagnosis of sepsis, might be helpful to provide adequate and timely management of critically ill patients, and thus reduce the morbidity and mortality associated with this condition.
|
31038735 |
2019 |
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The mouse model of sepsis was then established and the serum was extracted to detect interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α).
|
30915758 |
2019 |
Septicemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The absence of TRPM2 triggered less production of inflammatory mediators (IL-1β, IL-6, TNF-α) and decreased apoptosis related proteins (BNIP3, AIF, Endo G) expressions in response to LPS induced sepsis.
|
31450153 |
2019 |