Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Dot1l silencing or a Dot1l inhibitor preferentially suppressed the production of IL-6 and interferon (IFN)-β but not of TNF-α in macrophages and THP1 cells triggered by TLR ligands or virus infection.
|
30275539 |
2020 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Our findings provide the evidence that Rig-I is a key regulator of cellular senescence, which will be helpful in better understanding its function without viral infection.<b>Abbreviations:</b> Rig-I: retinoic acid inducible gene-I; SASP: senescence-associated secretory phenotype; ECM: extracellular matrix; Itgb3: integrin beta 3; PRR: pattern recognition receptor; MEFs: mouse embryonic fibroblasts; Il-1β: interleukin-1 beta; Il-6: interleukin-6; Il-8: interleukin-8; Cxcl1: chemokine (C-X-C motif) ligand 1; Ccl2: chemokine (C-C motif) ligand 2; WT, wild type; BM: bone marrow; MAPK: mitogen-activated protein kinase; ERK: extracellular signal-regulated kinases; JNK: Jun N-terminal kinases; SA-β-gal: senescence-associated β-galactosidase; qPCR: quantitative reverse-transcription PCR; PBS: phosphate-buffered saline.
|
31595820 |
2019 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The phenotypic changes included up-regulation of markers commonly associated with effector and exhausted cells and were induced by IL-6 in a STAT1-dependent manner in the context of chronic virus infection.
|
30745322 |
2019 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Similarly, in EV71-infected U251 cells, IL-6-Ab blocked EV71-induced IL-6 production and cell apoptosis in response to viral infection.
|
31730654 |
2019 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Virus infection prevented IL-6/GM-CSF-mediated differentiation of myeloid suppressors, but not CD163 macrophages, whereas infection of dendritic cells led to upregulation of maturation markers, including CD83, CD86, IL-12p70, and IFN-γ.
|
30617223 |
2019 |
Virus Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Furthermore, the hypomethylation effects of IBDV infection to the promoter regions of IL-6 and IRF7 genes were eliminated and relieved by betaine administration.
|
31162616 |
2019 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Med.</i> https://doi.org/10.1084/jem.20181589) show that virus-unspecific bystander memory T cells are highly affected during chronic viral infection via IL-6/STAT1.
|
30782615 |
2019 |
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The populations of KUL1<sup>+</sup>, CD3<sup>+</sup>CD4<sup>+</sup> and CD3<sup>+</sup>CD8<sup>+</sup> cells were significantly increased in both types of chickens at 3 dpi, and there was significant early depletion of IgM<sup>+</sup> B cells at 1 dpi in the red jungle fowl. vvIBDV infection also induced differential expression of genes that are involved in Th1 and pro-inflammatory responses, with groups receiving the higher dose (10<sup>6.8</sup> EID<sub>50</sub>) showing earlier expression of IFNG, IL12B, IL15, IL6, CXCLi2, IL28B, and TLR3 at 1 dpi.
|
29626271 |
2018 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
In humans with respiratory virus infections, such as Respiratory Syncytial Virus (RSV), elevated concentrations of IL-6 are associated with more severe disease.
|
28953978 |
2017 |
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Notably, co-infections led to a significant increase in the levels of TNF-α and IL-6, cytokines that are widely considered to play a crucial role in the early pathogenesis of both viral diseases.
|
28644900 |
2017 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
IL-6 production by macrophages is dramatically increased during double-mutant virus infection and correlates with faster antiviral responses in the host.
|
28292903 |
2017 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
IL-6 ameliorates acute lung injury in influenza virus infection.
|
28262742 |
2017 |
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Lung CD11c+ cells of BMT mice secrete more transforming growth factor beta-β1, and pro-TH17 mRNAs for IL-23 and IL-6, and less TH1-promoting cytokine mRNA for IFN-γ but slightly more IL-12 mRNA in response to viral infection.
|
26376362 |
2016 |
Virus Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The IL6 rs1818879 (GA) heterozygous genotype was associated with severe influenza A (H1N1) virus infection (odds ratio [OR] = 5.94, 95% confidence interval [CI] 3.05-11.56), and two IL1B SNPs, rs16944 AG and rs3136558 TC, were associated with a decreased risk of infection (OR = 0.52 and OR = 0.51, respectively).
|
26657940 |
2015 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Involvement of Interleukin 6 in Hepatitis B Viral Infection.
|
26343270 |
2015 |
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Viral infection (staining of F and G proteins, nucleoprotein RNA level), mRNA of ICAM-1, ciliated cell markers (digital high speed videomicroscopy, β-tubulin immunofluorescence, Foxj1 and Dnai2 mRNA), Goblet cells (PAS), mRNA of MUC5AC and CLCA1, mRNA and protein level of IL-13, IL-6, IL-8, TNFα, formation of H2O2 and the anti-oxidative armamentarium (mRNA of Nrf2, HO-1, GPx; total antioxidant capacity (TAC) were measured at day 10 or 15 post infection.
|
23936072 |
2013 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Human cells mounted vigorous cytokine (tumor necrosis factor alpha [TNF-α] and interleukin-6 [IL-6]) and chemokine (CXCL9, CXCL10, and CXCL11) responses to H5N1 virus infection.
|
22718824 |
2012 |
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We then examined cells with single or multiple virus infections for the expression of 10 cytokine genes and demonstrated elevated expressions for 7 (IFN-α, IFN-β, IFN-γ, TNF-α, IL-6, IL-8, and IL-17) in dual rotavirus and enterovirus or triple rotavirus, enterovirus and astrovirus-infected cells but only 3 (IFN-β, TNF-α, and IL-8) in dual rotavirus and astrovirus-infected cells.
|
22497974 |
2012 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Genetic or environmental factors that impair IL-6 production or signaling could increase mortality to influenza virus infection.
|
22294047 |
2012 |
Virus Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
When compared with C57BL/6 mice, Irf5(-/-) mice show higher susceptibility to viral infection and decreased serum levels of type I IFN and the inflammatory cytokines IL-6 and TNF-alpha.
|
20176957 |
2010 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, we identify a potential strategy (blockade of TNF and IL-6) for treatment of transplant recipients who have acute complications of viral infection.
|
20921283 |
2010 |
Virus Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Interleukin-6 haplotypes and the response to therapy of chronic hepatitis C virus infection.
|
19387461 |
2009 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The distribution of IL-6 and TNF-alpha was in the same area to HIV-1 and much greater than normal cervices from women with no evidence of viral infection.
|
16878360 |
2006 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
TNF-alpha and IL-6 are the cytokines most often detected during a CCHF viral infection.
|
16765637 |
2006 |
Virus Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The physiologic dimeric form of gal-1 is required for fusion inhibition because a monomeric gal-1 mutant had no inhibitory effect on cell fusion. gal-1 binds to specific N-glycans on NiV glycoproteins and aberrantly oligomerizes NiV-F and NiV-G, indicating a mechanism for fusion inhibition. gal-1 also increases dendritic cell production of proinflammatory cytokines such as IL-6, known to be protective in the setting of other viral diseases such as Ebola infections.
|
15972675 |
2005 |