|
Rheumatoid Arthritis
|
0.590 |
Biomarker
|
disease |
BEFREE |
In a previous study, the therapeutic effect of gp130-targeting LMT-28 was confirmed in RA.
|
31818460 |
2020 |
|
Rheumatoid Arthritis
|
0.590 |
Biomarker
|
disease |
BEFREE |
The IL-6-soluble IL-6Rα-gp130 complex is hyperactive in RA and OA.
|
29755657 |
2018 |
|
Rheumatoid Arthritis
|
0.590 |
Biomarker
|
disease |
BEFREE |
Immunohistochemical and immunofluorescence analysis was used to determine the expression and localization of IL-35 and its subunits (p35/EBI3) and IL-35 receptor (IL12Rβ2/gp130) in RA, osteoarthritis (OA) and psoriatic arthritis (PsA) synovial tissues.
|
25697137 |
2015 |
|
Rheumatoid Arthritis
|
0.590 |
Biomarker
|
disease |
BEFREE |
Furthermore, OSM also increased expression of its own receptors, gp130 and OSMR and the IL-1 receptor, IL1-R1; the latter effects were also observed in both human OASFs and RASFs.
|
24767864 |
2014 |
|
Rheumatoid Arthritis
|
0.590 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our results do not confirm an association of IL6R rs2228145 and IL6ST/gp130 rs2228044 polymorphisms with CV disease in RA.
|
21981268 |
2011 |
|
Rheumatoid Arthritis
|
0.590 |
Biomarker
|
disease |
CTD_human |
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
|
20453842 |
2010 |
|
Rheumatoid Arthritis
|
0.590 |
Biomarker
|
disease |
BEFREE |
Regulation of IL-6 transsignaling by the administration of soluble gp130 (sgp130) receptor to capture the IL-6/soluble IL-6R complex has shown promise for the treatment of rheumatoid arthritis (RA).
|
18796608 |
2008 |
|
Rheumatoid Arthritis
|
0.590 |
AlteredExpression
|
disease |
BEFREE |
Mice homozygous for the F759 mutation in the gp130 interleukin (IL)-6 receptor subunit have enhanced gp130-mediated signal transducer and activator of transcription (STAT)3 activation and spontaneously developed a lymphocyte-mediated rheumatoid arthritis-like joint disease.
|
16717113 |
2006 |
|
Rheumatoid Arthritis
|
0.590 |
Biomarker
|
disease |
MGD |
A point mutation of Tyr-759 in interleukin 6 family cytokine receptor subunit gp130 causes autoimmune arthritis.
|
12370259 |
2002 |
|
Rheumatoid Arthritis
|
0.590 |
Biomarker
|
disease |
BEFREE |
Blockade of the IL-6-gp130-JAK-STAT3-signaling pathway might therefore be beneficial in the treatment of RA.
|
11748261 |
2001 |
|
Rheumatoid Arthritis
|
0.590 |
Biomarker
|
disease |
BEFREE |
Inspection of autoantibodies to gp130-RAPS may become a practical clinical test for RA. gp130-RAPS and its autoantibody provide a new clue to the complicated pathogenesis of RA.
|
10880057 |
2000 |
|
Colorectal Carcinoma
|
0.510 |
AlteredExpression
|
disease |
BEFREE |
We found that APC loss also results in up-regulation of IL-6 signal transducer (IL-6ST/gp130), thereby activating Src family kinases (SFKs), YAP, and STAT3, which are simultaneously up-regulated in the majority of human CRC.
|
28130546 |
2017 |
|
Colorectal Carcinoma
|
0.510 |
Biomarker
|
disease |
CTD_human |
Unique methylation pattern of oncostatin m receptor gene in cancers of colorectum and other digestive organs.
|
19223499 |
2009 |
|
Colorectal Carcinoma
|
0.510 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Pneumonia
|
0.320 |
Biomarker
|
disease |
BEFREE |
Genetic reduction of Stat3 hyperactivity in gp130(F/F):Stat3(-/+) mice prevented lung inflammation and excessive protease activity; however, emphysema still developed.
|
22268122 |
2012 |
|
Pneumonia
|
0.320 |
Biomarker
|
disease |
CTD_human |
Expansion of CD4(+) CD25(+) and CD25(-) T-Bet, GATA-3, Foxp3 and RORγt cells in allergic inflammation, local lung distribution and chemokine gene expression.
|
21625544 |
2011 |
|
Pneumonia
|
0.320 |
AlteredExpression
|
disease |
LHGDN |
Together, the data suggest tissue-specific differences in IL-6-receptor-gp130-coupled signaling, thereby limiting the extent of Stat3 activation and gammaFBG expression during lung inflammation.
|
16524883 |
2006 |
|
Eczema
|
0.310 |
Biomarker
|
disease |
BEFREE |
A T cell-intrinsic increase of gp130 expression upon Ets1 deficiency promotes the gp130-mediated IL-6 signaling pathway, thereby leading to the development of severe AD-like symptoms.
|
30843878 |
2019 |
|
Eczema
|
0.310 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Loss of the interleukin-6 receptor causes immunodeficiency, atopy, and abnormal inflammatory responses.
|
31235509 |
2019 |
|
Carcinoma
|
0.310 |
GeneticVariation
|
group |
BEFREE |
Prompted by this finding, we assessed 110 Chinese lung carcinomas using PCR and direct DNA sequencing but found no somatic mutation of IL6ST in exon 6.
|
25242236 |
2015 |
|
ovarian neoplasm
|
0.310 |
Biomarker
|
disease |
BEFREE |
In this study, we show that gp130 is an attractive drug target in ovarian cancer due to its role in promoting cancer progression via the activation of its downstream Stat3 signaling.
|
23536726 |
2013 |
|
Malignant neoplasm of ovary
|
0.310 |
Biomarker
|
disease |
BEFREE |
In this study, we show that gp130 is an attractive drug target in ovarian cancer due to its role in promoting cancer progression via the activation of its downstream Stat3 signaling.
|
23536726 |
2013 |
|
Pneumonitis
|
0.310 |
Biomarker
|
disease |
BEFREE |
Genetic reduction of Stat3 hyperactivity in gp130(F/F):Stat3(-/+) mice prevented lung inflammation and excessive protease activity; however, emphysema still developed.
|
22268122 |
2012 |
|
Myocardial Ischemia
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
Cardiac ischemia-reperfusion regulates sympathetic neuropeptide expression through gp130-dependent and independent mechanisms.
|
21035185 |
2011 |
|
Pneumonitis
|
0.310 |
Biomarker
|
disease |
CTD_human |
Expansion of CD4(+) CD25(+) and CD25(-) T-Bet, GATA-3, Foxp3 and RORγt cells in allergic inflammation, local lung distribution and chemokine gene expression.
|
21625544 |
2011 |