IL6ST, interleukin 6 signal transducer, 3572

N. diseases: 260; N. variants: 6
Disease: Multiple Sclerosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.050 Biomarker disease BEFREE gp130 cytokines are differentially involved in regulating the T helper (H) 17-driven pathogenesis of experimental autoimmune encephalomyelitis (EAE), the animal model of human multiple sclerosis. 29770132 2018
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.050 Biomarker disease BEFREE We assessed the impact of natalizumab followed by fingolimod on the intra-individual changes of plasma protein levels of sIL-7Rα, sIL-2Rα and also sIL-6R and sgp130 in MS patients. 28941836 2018
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.050 AlteredExpression disease BEFREE Interleukin-11 (IL-11), a member of the gp130 family of cytokines, is upregulated in MS lesions. 23818742 2013
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.050 AlteredExpression disease BEFREE Cytokines of the gp130 family regulate survival and differentiation of both neural and immune cells, and we recently identified expression of the family member IL-11 in active MS plaques. 19734214 2009
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.050 AlteredExpression disease BEFREE CNTF-receptor complex members, CNTFRalpha, LIFRbeta and GP130, were increased in MS cortical neurons. 17898009 2007