IL6ST, interleukin 6 signal transducer, 3572

N. diseases: 260; N. variants: 6
Disease: Systemic Scleroderma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.030 AlteredExpression disease BEFREE Collectively, these results suggest that decreased serum LIF levels may be associated with vasculopathy in SSc and that Fli1 deficiency may contribute to the inhibition of LIF-dependent biological effects on SSc endothelial cells by suppressing the expression of LIF, LIF receptor, and gp130. 29038846 2017
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.030 AlteredExpression disease BEFREE We also found that gp130, the EBI3 receptor, was expressed in both normal and SSc fibroblasts. 26355156 2015
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.030 GeneticVariation disease BEFREE We aimed to investigate whether the functional genetic variants rs8192284 and rs2228044 previously associated with several autoimmune diseases, located within the IL-6 receptor (IL-6R) subunits IL6R and IL6ST genes, respectively, are involved in the susceptibility to SSc and/or its major clinical subphenotypes. 22742541 2012